National Healthcare Safety Network report, data summary for 2013, Device-associated Module

Dudeck, Margaret A.; Edwards, Jonathan R.; Allen-Bridson, Katherine; Gross, Cindy; Malpiedi, Paul; Peterson, Kelly; Pollock, Daniel A.; Weiner, Lindsey M.; Sievert, Dawn M.

doi:10.1016/j.ajic.2014.11.014

Cited by 305 publications

(273 citation statements)

References 3 publications

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“…As context, from the 82 US hospitals reporting to the National Healthcare Safety Network in 2013, .2.7 million CVAD catheter days in the pediatric and neonatal population were registered. 134 Applying the rate of failure described in our study, 5457 pediatric and neonatal CVADs in US hospitals failed before completion of treatment in 1 year alone. These failures place a massive economic and physical burden on the US health care system, patients, and families.…”

Section: Conclusion and Future Researchmentioning

confidence: 99%

Complications of Central Venous Access Devices: A Systematic Review

et al. 2015

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CONTEXT: The failure and complications of central venous access devices (CVADs) result in interrupted medical treatment, morbidity, and mortality for the patient. The resulting insertion of a new CVAD further contributes to risk and consumes extra resources.OBJECTIVE: To systematically review existing evidence of the incidence of CVAD failure and complications across CVAD types within pediatrics.DATA SOURCES: Central Register of Controlled Trials, PubMed, and Cumulative Index to Nursing and Allied Health databases were systematically searched up to January 2015.STUDY SELECTION: Included studies were of cohort design and examined the incidence of CVAD failure and complications across CVAD type in pediatrics within the last 10 years. CVAD failure was defined as CVAD loss of function before the completion of necessary treatment, and complications were defined as CVAD-associated bloodstream infection, CVAD local infection, dislodgement, occlusion, thrombosis, and breakage. CONCLUSIONS: CVAD failure and complications in pediatrics are a significant burden on the health care system internationally.

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Section: Conclusion and Future Researchmentioning

confidence: 99%

Complications of Central Venous Access Devices: A Systematic Review

et al. 2015

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“…Resource-limited countries contributing data to the International Nosocomial Infection Control Consortium (INICC) report NICU CLABSI rates of 3 -4-fold higher than those documented by the US National Health Surveillance System (NHSN). [2,3] In high-income-country NICUs, CLABSI rates declined dramatically following widespread implementation of central-line bundles. [4] A CLABSI bundle is a strategy for insertion and maintenance of central lines, which includes several evidence-based best practices implemented simultaneously.…”

Section: Researchmentioning

confidence: 99%

Central-line-associated bloodstream infections in a resource-limited South African neonatal intensive care unit

et al. 2017

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Background. The rate of central-line-associated bloodstream infection (CLABSI) in South African (SA) public sector neonatal intensive care units (NICUs) is unknown. Tygerberg Children's Hospital (TCH), Cape Town, introduced a neonatal CLABSI surveillance and prevention programme in August 2012. Objectives. To describe CLABSI events and identify risk factors for development of CLABSI in a resource-limited NICU. Methods. A retrospective case-control study was conducted using prospectively collected NICU CLABSI events matched to four randomly selected controls, sampled from the NICU registry between 9 August 2012 and 31 July 2014. Clinical data and laboratory records were reviewed to identify possible risk factors, using stepwise forward logistic regression analysis. Results. A total of 706 central lines were inserted in 530 neonates during the study period. Nineteen CLABSI events were identified, with a CLABSI rate of 5.9/1 000 line days. CLABSI patients were of lower gestational age (28 v. 34 weeks; p=0.003), lower median birth weight (1 170 g v. 1 975 g; p=0.014), had longer catheter dwell times (>4 days) (odds ratio (OR) 5.1 (95% confidence interval (CI) 1.0 -25.4); p=0.04) and were more likely to have had surgery during their NICU stay (OR 3.5 (95% CI 1.26 -10); p=0.01). Significant risk factors for CLABSI were length of stay >30 days (OR 20.7 (95% CI 2.1 -203.2); p=0.009) and central-line insertion in the operating theatre (OR 8.1 (95% CI 1.2 -54.7); p=0.03). Gram-negative pathogens predominated (12/22; 54%), with most isolates (10/12; 83%) exhibiting multidrug resistance. Conclusion. The TCH NICU CLABSI rate is similar to that reported from resource-limited settings, but exceeds that of high-income countries. Prolonged NICU stay and central-line insertion in the operating theatre were important risk factors for CLABSI development. Intensified neonatal staff training regarding CLABSI maintenance bundle elements and hand hygiene are key to reducing CLABSI rates.

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“…[4][5][6][7] According to National Healthcare Safety Network (NHSN) data, CLABSI incidence continues to be highest in the HCT population, wherein rates are higher than in any other high-risk population, including solid organ transplant and burn patients, or care setting (that is, intensive care units). 8 This paper will review the impact of bacterial BSI in the current transplant period as measured by resource utilization and associated morbidity and mortality in allo-HCT patients. The manuscript will also offer insight into emerging resistant pathogens responsible for causing bacterial BSI and novel antimicrobial therapies and approaches implemented to reduce BSI-related morbidity and mortality in allo-HCT patients.…”

Section: Introductionmentioning

confidence: 99%

Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

Dandoy

Ardura

Papanicolaou

et al. 2017

Bone Marrow Transplant

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Bacterial bloodstream infections (BSI) cause significant transplant-related morbidity and mortality following allogeneic hematopoietic cell transplantation (allo-HCT). This manuscript reviews the risk factors for and the bacterial pathogens causing BSIs in allo-HCT recipients in the contemporary transplant period. In addition, it offers insight into emerging resistant pathogens and reviews clinical management considerations to treat and strategies to prevent BSIs in allo-HCT patients.

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National Healthcare Safety Network report, data summary for 2013, Device-associated Module

Cited by 305 publications

References 3 publications

Complications of Central Venous Access Devices: A Systematic Review

Complications of Central Venous Access Devices: A Systematic Review

Central-line-associated bloodstream infections in a resource-limited South African neonatal intensive care unit

Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

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