National Health Service White Paper. Will it work for patients?

Appleyard, W. J.

doi:10.1136/adc.64.4.643

Cited by 4 publications

(1 citation statement)

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“…The role of oxidative responses to nPM was analyzed with N-acetyl L-cysteine (NAC), a general antioxidant, which blocked pro-oxidative effects of nPM in brain slices [13] and of diesel PM0.2 in endothelia [38]. NAC treatment attenuated nPM induced oxidative responses as shown by inhibiting the increases in MitoSOX fluorescence (−50%, p<0.01) and 4-HNE (−2-fold, p<0.005) levels (Fig.…”

Section: Inhibition Of Oxidative Stress By Nac Attenuated Npm-induced Changesmentioning

confidence: 99%

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

Cacciottolo

Morgan

Saffari

et al. 2020

Free Radical Biology and Medicine

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Traffic-related air pollution particulate matter (TRAP-PM) is associated with increased risk of Alzheimer Disease (AD). Rodent models respond to nano-sized TRAP-PM (nPM) with increased production of amyloid Aβ peptides, concurrently with oxidative damage. Because pro-Aβ processing of the amyloid precursor protein (APP) occurs on subcellular lipid rafts, we hypothesized that oxidative stress from nPM exposure would alter lipid rafts to favor Aβ production. This hypothesis was tested with J20 mice and N2a cells transgenic for hAPPswe (familial AD). Exposure of J20-APPswe mice to nPM for 150 hours caused increased lipid oxidation (4-HNE) and increased the pro-amyloidogenic processing of APP in lipid raft fractions in cerebral cortex; the absence of these changes in cerebellum parallels the AD brain region selectivity for Aβ deposits. In vitro, nPM induced similar oxidative responses in N2a-APPswe cells, with dose-dependent production of NO, oxidative damage (4-HNE, 3NT), and lipid raft alterations of APP with increased Aβ peptides. The antioxidant N-acetyl-cysteine (NAC) attenuated nPM-induced oxidative damage and lipid raft alterations of APP processing. These findings identify neuronal lipid rafts as novel targets of oxidative damage in the proamyloidogenic effects of air pollution.

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Section: Inhibition Of Oxidative Stress By Nac Attenuated Npm-induced Changesmentioning

confidence: 99%

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

Cacciottolo

Morgan

Saffari

et al. 2020

Free Radical Biology and Medicine

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Closing the loop between evidence-based medicine and care delivery: a possible role for clinical audits in spinal surgery

Dazley¹,

Thomas²,

Harris³

et al. 2013

The Spine Journal

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Children's services in the new NHS--a struggle for survival?

Appleyard¹

1990

Archives of Disease in Childhood

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At the present time of change, muddle, and uncertainty in the health service, there are opportunities to improve services for children if we can build on the certainty of our commitment to an integrated child health service. In reply to the British Paediatric Association's (BPA) response to the government's white paper Working for Patients, the Secretary of State, Mr Kenneth Clarke, wrote 'I am aware that successive expert studies-the Court report, the Maternity Services Advisory Committee reports-have described the need for integration [of comprehensive hospital and community services for children] and I have no doubt that this is necessary for the effective delivery of services. I expect districts to share this view and to seek to contract for integrated children's services'. (K Clarke, letter to Professor June Lloyd, President of the BPA, 1989.) Under the new arrangements each district health authority or any number of health authorities joining together to form a consortium 'purchaser' will be reviewing the medical services in their districts. As child health surveillance is now primarily to be undertaken in general practice, it is essential that a comprehensive consultant children's service is organised to support the acute needs of children and those discovered during the surveillance programmes in each health district.

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National Health Service White Paper. Will it work for patients?

Cited by 4 publications

References 0 publications

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

Closing the loop between evidence-based medicine and care delivery: a possible role for clinical audits in spinal surgery

Children's services in the new NHS--a struggle for survival?

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