Natalizumab‐induced acquired perforating dermatosis

Hadley, G. P.; Ieremia, Eleni; Moswela, Olivia; Zaki, F; DeLuca, Gabriele C.; McPherson, Tess

doi:10.1111/ced.14699

Cited by 2 publications

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“…1,2 Several later studies show that both collagen and elastin could penetrate the surface of RPC-like lesions. [3][4][5] There may be different results of PF, KD and RPC in the same patient depending on the sites, period, and layers of the biopsy. 3,6,7 This type of disease is therefore considered to be uniformly named acquired perforating dermatoses (APD).…”

Section: Introductionmentioning

confidence: 99%

“…Based upon the nature of the eliminated material and the type of epidermal disorder, acquired perforating dermatoses traditionally tend to be divided into four subtypes: Kyrle's disease (KD), perforating folliculitis (PF), elastosis perforans serpiginosa (EPS), and reactive perforating collagenosis (RPC) 1,2 . Several later studies show that both collagen and elastin could penetrate the surface of RPC‐like lesions 3–5 . There may be different results of PF, KD and RPC in the same patient depending on the sites, period, and layers of the biopsy 3,6,7 .…”

Section: Introductionmentioning

confidence: 99%

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Acquired perforating dermatosis: A clinicopathologic study, and the features of dermoscopy and reflective confocal microscopy of 37 cases

Gao

Shan

2023

Skin Research and Technology

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Background: Acquired perforating dermatosis (APD) is a rare skin condition characterized by degenerated materials eliminated from the dermis. Several retrospective studies on APD have been reported; however, few data are available on Chinese APD and their features on dermoscopy and reflective confocal microscope (RCM) assays. Objective:The aim of this study was to retrospectively evaluate the clinical and histopathologic data of 37 acquired perforating dermatosis cases, and assess their features on dermoscopy and RCM.Methods: Thirty-seven APD patients were retrospectively enrolled in our study. We characterized the clinical histopathological features, concomitant diseases, treatment responses, and the dermoscopy and RCM findings.Results: Pruritus was the most common symptom, with the lower extremities as the most predilection sites (86.5%, n = 32; 91.9%, n = 34, respectively). Concomitant diseases were found in 34 patients (92.6%), among which diabetes mellitus was the most common, followed by thyroid nodules, allergic dermatosis, and chronic renal insufficiency. Dermoscopy and RCM assays were performed in 11 patients. The typical RCM images were hyperreflective cord-like structures from the epidermis to dermis. Dermoscopy features of fully developed lesions showed central ulceration with peripheral hairpin-like or loop-like capillaries with characteristic garland arrangements. Conclusion: APD is an uncommon skin disorder associated with various systemic conditions in Chinese individuals. Thyroid disorders are an overlooked complication and may play an important role in the development of APD. The results of this study indicate that noninvasive dermoscopy and RCM examination are helpful in the rapid diagnosis and early intervention of APD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acquired perforating dermatosis: A clinicopathologic study, and the features of dermoscopy and reflective confocal microscopy of 37 cases

Gao

Shan

2023

Skin Research and Technology

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“…1 Natalizumab and other biologics have also been implicated to cause APD. 2 Although still unknown, the pathogenesis of APD in patients with systemic disease is believed to consist of microangiopathy from endocrine disturbances, dermal deposition of compounds that remain after hemodialysis, or pruritus that results in cutaneous trauma which then leads to subsequent damage to the dermal-epidermal junction. 3 This damage is believed to facilitate keratinocyte interaction with modified or damaged connective tissue elements in a manner that results in their transepidermal elimination.…”

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confidence: 99%

Acquired Reactive Perforating Collagenosis Occurring in Association With Nonred Ink Tattoo

Grube

Safeer

Hafeez

2022

The American Journal of Dermatopathology

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Perforating dermatosis is a group of skin conditions in which there is transdermal elimination of collagen, elastic fibers, or other dermal connective tissue. Perforating dermatosis can be genetic or acquired, known as acquired perforating dermatosis (APD). When collagen is the primary extruded material in acquired cases, the disease is designated as acquired reactive perforating collagenosis (RPC). We report a case of acquired RPC occurring in a new tattoo. One week after having a new tattoo placed on the left forearm, a 38-year-old gentleman presented to the emergency room with pruritic, crusted plaques and erosions in the regions of red and green inks of the tattoo. Histopathologic examination of the biopsy revealed an ulceration with transepidermal elimination of collagen bundles accompanied by basophilic debris, scattered dermal tattoo pigment, and a superficial to deep perivascular lymphohistiocytic infiltrate with scattered neutrophils and eosinophils. There have been 2 reported cases of tattooassociated RPC, both in association with red tattoo ink. This present case is the first reported APD to occur in association with nonred tattoo ink. This case reaffirms the conclusions of others in recognizing APD as a potential tattoo-associated complication.

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Natalizumab‐induced acquired perforating dermatosis

Abstract: Click https://wileyhealthlearning.com/#/online-courses/615dfa64-8585-45a0-9acd-78a11677651e for the corresponding questions to this CME article.

Cited by 2 publications

References 3 publications

Acquired perforating dermatosis: A clinicopathologic study, and the features of dermoscopy and reflective confocal microscopy of 37 cases

Acquired perforating dermatosis: A clinicopathologic study, and the features of dermoscopy and reflective confocal microscopy of 37 cases

Acquired Reactive Perforating Collagenosis Occurring in Association With Nonred Ink Tattoo

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