Natalizumab in 4 cases of pediatric multiple sclerosis

Huppke, Peter; Stark, Wiebke; Zürcher, Claudia; Huppke, Brenda; Brück, W.; Gartner, J. Carlton

doi:10.1055/s-0029-1215731

Cited by 2 publications

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“…Natalizumab was the first-line treatment in most patients (27.8%), followed by the longer in use Interferons (Interferon Beta-1a, 16.7%; Interferon Beta-1b, 5.6%) and Glatiramer acetate (11.1%). The data currently available for POMS patients who did not respond to initial immunomodulatory treatments indicate that Natalizumab is effective in reducing clinical relapses in most cases (Huppke et al, 2008;Arnal-Garcia et al, 2013). It is important to note that the vast majority of patients included in the study started their treatment before the formal approval of Fingolimod, Teriflunomide and Dimethylfumarate for the treatment of POMS.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil/lymphocyte and monocyte/lymphocyte indexes as potential predictors of relapse at 1 year after diagnosis of pediatric multiple sclerosis: a single-center, exploratory and proof-of-concept study

Palavra,

Geria,

Jorge

et al. 2024

Front. Neurosci.

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IntroductionEarly identification of patients with a more unfavorable outcome in Multiple Sclerosis (MS) is crucial to optimize individualized treatment. Neutrophil-lymphocyte index (NLI) and monocyte-lymphocyte index (MLI) have been considered as potential biomarkers for disease prognosis. Our study aims to investigate the usefulness of NLI and MLI as predictors of relapse, disability progression, and lesion accumulation on magnetic resonance imaging (MRI) 1 year after diagnosis and treatment initiation, in pediatric-onset MS.MethodsA retrospective single-center study was conducted, including patients with diagnosis of MS established in pediatric age (<18 years old), at least 1-year of follow-up, and a complete blood count (CBC) performed at diagnosis. We collected the nearest-to-diagnosis NLI and MLI, as well as clinical and imaging variables, at diagnosis and 12 months later. Our cohort was further dichotomized into two groups, based on the presence of relapses. Statistical significance was considered for p < 0.05.ResultsEighteen patients (n = 18) were included. The relapsing group had higher mean, minimum, and maximum values for both NLI (5.17 ± 5.85, range: 1.57–11.92) and MLI (0.35 ± 0.22, range: 0.19–0.59), compared to the non-relapsing group (2.19 ± 1.63, range: 1.12–7.32 for NLI, and 0.24 ± 0.09, range: 0.14–0.44 for MLI). A higher percentage of patients in the relapsing group had increased NLI (>1.89, 66.7%) and MLI (>0.21, 66.7%) values than those in the non-relapsing group (46.7%). Patients who presented new T2-hyperintense lesions on MRI after 1 year of follow-up also had higher mean, minimum, and maximum values of both biomarkers. Patients who did not achieve No Evidence of Disease Activity-3 (NEDA-3) state exhibited higher values for both ratios. However, in our sample, no statistically significant correlations were found between MLI and NLI values and the clinical and imaging variables considered.ConclusionThe ease of obtaining NLI and MLI from routine blood tests renders them useful biomarkers as a screening tool in longitudinal follow-up. Our study was based on a very small sample size, but it allowed us to verify the feasibility of the protocol used. It is intended to involve other centers in the next phase of this work, testing the possible usefulness of the indices under analysis on a larger sample.

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Section: Discussionmentioning

confidence: 99%

Neutrophil/lymphocyte and monocyte/lymphocyte indexes as potential predictors of relapse at 1 year after diagnosis of pediatric multiple sclerosis: a single-center, exploratory and proof-of-concept study

Palavra,

Geria,

Jorge

et al. 2024

Front. Neurosci.

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“…According to Huppke (2013), the ability to comprehend and regulate one's emotions is referred to as emotional intelligence. Self-awareness, self-regulation, motivation, empathy, and social skills are all components of emotional intelligence.…”

Section: Social and Emotional Skillsmentioning

confidence: 99%

2030 Work Skills as Predictors of Pre-Service Science Teachers’ Readiness to Implement 21st Century Learning

Borlaza,

Jan P. Lozada,

Gregana

2023

IJSMR

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This study focused on the 2030 work skills recommended by the Organisation for Economic Cooperation and Development that predicts the readiness of the Pre-Service Science Teachers in implementing 21st century learning. The researcher used a descriptive-correlational quantitative research design and regression analysis that was adopted, and statistical tools were used to assess the relationship between independent and dependent variables. It was conducted in Laguna State Polytechnic University campuses; Los Banos, San Pablo, Siniloan and Sta. Cruz. Based on the findings, the study revealed that there is a significant relationship between cognitive and metacognitive, social and emotional, and practical and physical skills to their readiness to implement 21st-century learning. In regression analysis, it revealed that as the practical and physical skills of the pre-service teacher’s increases, their readiness to implement also increases. The findings of the study may provide pre-service science teachers a guide on the skills needed in 2030 so they can focus more on what area or aspect they need to improve. Likewise, the teachers may create a learning environment where pre-service teachers will be more engaged and help them utilize their full capacity. Furthermore, the University or any educational institution may offer webinars/seminars regarding the skills needed by the preservice teachers as well as training. Future researchers may be motivated to conduct further studies by employing other variables.

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Natalizumab in 4 cases of pediatric multiple sclerosis

Cited by 2 publications

References 0 publications

Neutrophil/lymphocyte and monocyte/lymphocyte indexes as potential predictors of relapse at 1 year after diagnosis of pediatric multiple sclerosis: a single-center, exploratory and proof-of-concept study

Neutrophil/lymphocyte and monocyte/lymphocyte indexes as potential predictors of relapse at 1 year after diagnosis of pediatric multiple sclerosis: a single-center, exploratory and proof-of-concept study

2030 Work Skills as Predictors of Pre-Service Science Teachers’ Readiness to Implement 21st Century Learning

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