NAT10-mediated RNA ac4C acetylation contributes to the myocardial infarction induced cardiac fibrosis
Jun Li,
Feierkaiti Yushanjiang,
Zhao Fang
et al.
Abstract:Cardiac fibrosis is featured cardiac fibroblast activation and extracellular matrix accumulation. Ac4C acetylation is an important epigenetic regulation of RNAs that has been recently discovered, and it is solely carried out by NAT10, the exclusive enzyme used for the modification. However, the potential regulatory mechanisms of ac4C acetylation in myocardial fibrosis following myocardial infarction remain poorly understood. In our study, we activated fibroblasts in vitro using TGF-β1 (20 ng/mL), followed by e… Show more
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