Nasoseptal Cholesterol Granuloma<subtitle>A Case Report and Review of Pathogenesis</subtitle>

Huge Cholesterol Granuloma in Nasoseptal Region

“…The The precise pathogenesis of CG has not been fully elucidated yet, but 2 explanatory hypotheses have been proposed, namely the obstruction-vacuum-and the exposed marrow hypotheses, respectively. 1 Both hypotheses proposed that the trapped blood in the closed cavities undergoes degeneration, which triggers an inflammatory macrophage-mediated granulomatous foreign body reaction against the hemosiderin that emerges during the breakdown process of hemorrhagic blood products. 2,3 Cholesterol granuloma may be precipitated by trauma, surgery, or recurrent sinusitis attacks leading to bleeding into a closed bony cavity and accumulation of blood in a space with interrupted ventilation.…”

“…2,3 Cholesterol granuloma may be precipitated by trauma, surgery, or recurrent sinusitis attacks leading to bleeding into a closed bony cavity and accumulation of blood in a space with interrupted ventilation. 1,2,4 The CGs are more common in the fifth decade of life with a male predominance, and triggering previous trauma or surgery history is present in 14% and 11% of all cases, respectively. 5 The most frequently reported location of CG is frontal sinuses.…”

“…Nur Yü cel Ekici, MD 1 A 55-year-old male patient was presented with the complaints of nasal obstruction, anosmia, epiphora, and midfacial pressure perception persisting for past 5 months. His past history revealed a traumatic facial airbag crash during a car accident approximately 9 years ago.…”

Orphan diseases of the nose and paranasal sinuses: Pathogenesis – clinic – therapy

“…Postoperatively, more than 90% of the patients are symptom-free (follow-up of 35 months) [ 118 ], [ 119 ], [ 120 ], [ 121 ].…”

Cholesterol Granuloma of Nasal Septum

“…So far, only one case has been reported. 2) The pathogenesis of cholesterol granuloma is still with controversy. We present one case of cholesterol granuloma of nasal septum discovered by chance during septoplasty.…”