Nasopharyngectomy for Recurrent Nasopharyngeal Carcinoma: A Review of 31 Patients and Prognostic Factors

To, Edward W.H.; Lai, Eric Ch; Cheng, Jack H.H.; Pang, Polly; Williams, M. D.; Teo, Peter M.L.

doi:10.1097/00005537-200210000-00033

Cited by 53 publications

(45 citation statements)

References 28 publications

(61 reference statements)

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“…When a tumor invades the skull base and the neighboring tissues (including the brain lobe cavernous sinus and internal carotid arteries), it is very difficulty to eradiate. In the previous reports, tumor with intracranial and skull base invasion was considered a contraindication for salvage surgery [23]. In the present study, 17 consecutive patients underwent skull base surgery between 1997 and 2005.…”

Section: Discussionmentioning

confidence: 75%

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A retrospective study of salvage surgery for recurrent nasopharyngeal carcinoma

2011

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Section: Discussionmentioning

confidence: 75%

“…To et al [23] reported their experience of salvage surgery in 31 patients, with 6 patients having concurrent cervical nodal metastasis. During the follow-up, 4 of them died, with a mean survival of 9 months, and the authors concluded that cervical nodal metastases carry a poor prognosis for salvage surgery of recurrent NPC.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of salvage surgery for recurrent nasopharyngeal carcinoma

2011

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“…When tumour persists or recurs after the initial therapy, surgeryoffers better local tumour control and survival [15][16][17][18] as well as less post-treatment morbidities than reirradiation.…”

Section: Discussionmentioning

confidence: 99%

The role of elective neck dissection during surgical salvage for recurrent nasopharyngeal carcinoma

Chan

Wei

2014

J Nasopharyng Carcinoma

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Background:To study the incidence of microscopic tumour deposit in the neck in patients with recurrent nasopharyngeal carcinoma (NPC) and hence, the role of routine elective neck dissection during nasopharyngectomy. Methods:Retrospective review of the pathology report of the selective neck dissection specimens in patients with recurrent NPC and clinically N0 status. Results:Between 2000 and 2012, 38 patients presented with recurrent NPC requiring maxillary swing nasopharyngectomy and free flap reconstruction. The initial T-classification of the tumour was T1, 15.8%; T2, 52.6%; and T3, 31.6%, and the N-classification was N0, 26.3%; N1, 47.4%, N2, 15.8%; and N3, 10.5%. Concurrent chemoradiation was given in 57.9% of the subjects. All patients in the series had complete response after the initial treatment, and the mean time to develop local tumour recurrence was 22.3 months. Among these patients, only 1 (2.6%) demonstrated microscopic tumour metastasis in 1 lymph node removed during selective neck dissection.Conclusions:Given the low incidence of microscopic tumour metastasis in patients with recurrent NPC and clinically N0 status, routine elective neck dissection may not be indicated. Further large scale investigation is indicated to address the issue.

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“…Satisfactory results of surgical salvage of recurrent tumour in the nasopharynx have been reported [20][21][22][23]. The nasopharynx can be approached through the infratemporal fossa from the lateral aspect [24].…”

Section: Salvage Surgery For Disease In the Nasopharynxmentioning

confidence: 99%