Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged less than five years

Ceyhan, Mehmet; Karadağ‐Öncel, Eda; Hasçelik, Gülşen; Üstündağ, Gülnihan; Gurbuz, Venhar; Şamlıoğlu, Pınar; Yılmaz, Nisel; Özsürekçi, Yasemin; Yılmaz, Elif; Aykaç, Kübra; Öz, Fatma Nur; Üzüm, Özlem; Orsdemir-Hortu, Hacer; Tanır, Gönül; Yilmaz-Ciftdogan, Dilek; Kurugöl, Zafer

doi:10.1016/j.vaccine.2021.03.028

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…The predominant colonizing serotype in this study was 15B, as shown previously in children aged <5 years ( Ceyhan et al., 2021 ). Serotypes 6B, 6C, 19F and 11A were also fairly common in both age groups.…”

Section: Discussionsupporting

confidence: 88%

Pneumococcal nasopharyngeal carriage in children under 5 years of age at an outpatient healthcare facility in Novi Sad, Serbia during the COVID-19 pandemic

Petrović¹,

Milosavljevic²,

Djilas³

et al. 2022

IJID Regions

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Section: Discussionsupporting

confidence: 88%

Pneumococcal nasopharyngeal carriage in children under 5 years of age at an outpatient healthcare facility in Novi Sad, Serbia during the COVID-19 pandemic

Petrović¹,

Milosavljevic²,

Djilas³

et al. 2022

IJID Regions

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“…Although 13-valent pneumoniae conjugate vaccine (PCV13) has been formally introduced in China since June 2017, it has not been included in the National Immunization Plan, and variant serotypes of S. pneumoniae emerge incessantly, which can lead to ineffectiveness of existing vaccines (13). Moreover, it has been reported that the total carrying rate of S. pneumoniae in children is up to 17.8% (14). Patients with IPD are at risk of insomnia, hearing impairment, language and mental developmental delays (15)(16)(17), and even septic shock and death in severe cases (18).…”

Section: Discussionmentioning

confidence: 99%

The application value of metagenomic next-generation sequencing in children with invasive pneumococcal disease

Guo¹,

Liu²,

Xu³

2021

Transl Pediatr

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“…Nasopharyngeal S. pneumoniae carriage prevalence in Turkish children younger than 5 years is 17.8%. 37 S. pneumoniae and H. influenzae can be a part of the normal nasopharyngeal flora, and their presence does not necessarily indicate an infection. Therefore, it could not be conclusively determined whether bacterial pathogens were disease-causing agents.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Tract Pathogens in the COVID-19 Era: Data from a Pediatric Emergency Department

Yildiz

Ünal

Aydın

et al. 2021

J Pediatr Infect Dis

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Objective The frequency of coinfections in pediatric Coronavirus disease 2019 (COVID-19) cases and their impact on the clinical course are not fully understood. We aimed to investigate the viral and bacterial respiratory pathogens in children admitted to the pediatric emergency department (PED), their clinical course, and the presence of coinfections during the early months of the COVID-19 pandemic. Methods Clinical, laboratory and radiological findings, viral and bacterial pathogens detected by multiplex polymerase chain reaction (PCR) tests in nasopharyngeal swabs, clinical course, and treatments of all children who were tested for severe acute respiratory coronavirus 2 (SARS-CoV-2) at the PED between March 16 and May 15, 2020, were recorded. SARS-CoV-2 PCR-positive and negative groups were compared. Results Out of 570 patients tested for SARS-CoV-2 during the study period, 43 were found positive (7.5%). Non-SARS-CoV-2 viral pathogens were more common in the SARS-CoV-2 PCR-negative group than the SARS-CoV-2 PCR-positive group (13.2%, n = 68 versus 4.7%, n = 2), but this result was not statistically significant. Leukocyte, neutrophil, lymphocyte, and platelet counts were lower in SARS-CoV-2 PCR-positive group. Bacterial panel positivity was significantly higher in the SARS-CoV-2 PCR-positive group compared with the SARS-CoV-2 PCR-negative group (52%, n = 12 versus 28%, n = 91; p < 0.05). The presence of coinfection did not alter the course of therapy in SARS-CoV-2 PCR-positive cases. Conclusion While viral coinfections were rare, bacterial panel positivity was common in children with COVID-19, but this had not influenced management decisions. The limitations of the tests should be kept in mind while interpreting the results.

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Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children aged less than five years

Cited by 10 publications

References 34 publications

Pneumococcal nasopharyngeal carriage in children under 5 years of age at an outpatient healthcare facility in Novi Sad, Serbia during the COVID-19 pandemic

Pneumococcal nasopharyngeal carriage in children under 5 years of age at an outpatient healthcare facility in Novi Sad, Serbia during the COVID-19 pandemic

The application value of metagenomic next-generation sequencing in children with invasive pneumococcal disease

Respiratory Tract Pathogens in the COVID-19 Era: Data from a Pediatric Emergency Department

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