Nasopharyngeal carcinoma with cranial nerve palsy: The importance of MRI for radiotherapy

Nasopharyngeal carcinoma (NPC) is the most common primary neoplasm to arise in the nasopharynx. It is an aggressive tumor with a propensity for local tumour invasion and a high incidence of metastases to cervical lymph nodes. Due to its central location in the nasopharynx, primary tumours have many potential routes of local spread, including into important spaces such as the orbital and intracranial spread. This article discusses the current imaging techniques used in the diagnosis and staging of nasopharyngeal carcinoma, and reviews the 7 th edition of the International Union Against Cancer (UICC) and American Joint Committee on Cancer (AJCC) TMN staging system for nasopharyngeal carcinoma.

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“…MRI is also more reliable for differentiating between the primary tumor and retropharyngeal adenopathy [14][15][16][17].…”

Section: Role Of Imagingmentioning

confidence: 99%

Imaging of Nasopharyngeal Carcinoma

Chan

Sahgal

Fatterpekar

et al. 2014

J Nasopharyng Carcinoma

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“…MRI is commonly used in assessment of local involvement of NPC, which can clearly show the involvement of soft tissue, bone as well as the intracranial lesion [3,4]. On the contrary, 18 F-FDG…”

Section: Local Invasionmentioning

confidence: 99%

Use Of 18F-FDG PET/CT In The Diagnosis, Staging, Response Assessment And Prognosis Of Nasopharyngeal Carcinoma: An Updated Review

Yang

2014

J Nasopharyng Carcinoma

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“…Tropism for PNI is found more commonly in adenoid cystic carcinomas (Gomez et al 2008 ), nasopharyngeal carcinoma (Chang et al 2005 ), sinonasal carcinoma (undifferentiated) (Gil et al 2009 ), squamous cell carcinoma, salivary gland carcinoma, and adenocarcinoma. PNI is fairly uncommon in sarcomas or malignant melanoma.…”

Section: Primary Tumor Site and Cranial Nerves At Riskmentioning

confidence: 99%

“…Table 4 identifi es primary tumor sites in the head and neck and the associated cranial nerves at risk for perineural spread. Direct extension to PTF Nasopharynx (Chang et al 2005 ;Lu et al 2001 ) V and VI (less common II, III, IV, XII) Direct extension to Meckel's cave, cavernous sinus, and carotid space Nose (Barnett et al 2013 ) V (Table 5 ) 6 Cases…”

Section: Primary Tumor Site and Cranial Nerves At Riskmentioning

confidence: 99%