Nasopharyngeal carcinoma: understanding its molecular biology at a fine scale

Paul, Prosenjit; Deka, Himangshu; Malakar, Arup Kumar; Halder, Binata; Chakraborty, Supriyo

doi:10.1097/cej.0000000000000314

Cited by 37 publications

(20 citation statements)

References 77 publications

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“…Analysis of sex differences sheds light on the reasons for the marked sex difference in NPC incidence in China and the rest of the world [47,48]. The model estimation results indicate that NO 2 has a significantly greater effect on men than on women.…”

Section: Discussionmentioning

confidence: 96%

Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013

Yang

Liu

Zhao

et al. 2020

IJERPH

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Large cities in China are experiencing severe ambient air pollution. Although China accounts for more than 45% of new cases of nasopharyngeal carcinoma worldwide in 2018, few studies have examined the association between ambient air pollution and the high nasopharyngeal carcinoma (NPC) incidence in China. Thus, we aim to investigate whether exposure to ambient air pollution (including nitrogen dioxide, sulfur dioxide, and PM10) would significantly affect NPC incidence in large Chinese cities. We collected panel data of ten Chinese provincial cities about local NPC incidence, air pollution level, meteorology, and city profiles during 2006 to 2013 to construct a two-way fixed-effects model to explore the association between ambient air pollution and NPC incidence, as well as possible regional and gender differences behind the association. We found that NO2 had the strongest association with NPC incidence, and the relative risks were 2.2995 (95% CI, 1.2567–4.2075) for males and 1.3010 (95% CI, 0.8212–2.0620) for females, respectively. Under cumulative exposure, it was still NO2 that had the strongest association with NPC incidence, with a relative risk of 1.8836 (95% CI, 1.2416–2.8577), compared to 1.0857 (95% CI, 0.9474–1.2450) and 1.0547 (95% CI, 0.8790–1.2663) for SO2 and PM10, respectively. In addition, males were found more sensitive to ambient air pollution than females. We also found that southern Chinese cities were more sensitive to NO2 than northern cities, which might be related to a higher humidity there. Our study reveals that exposure to ambient air pollutants like SO2, PM10, and particularly NO2, is significantly positively associated with NPC incidence in China.

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Section: Discussionmentioning

confidence: 96%

Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013

Yang

Liu

Zhao

et al. 2020

IJERPH

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“…In addition to heredity and susceptible human genes, a carcinogenic virus, EBV, was detected in 100% of undifferentiated non-keratinizing NPC patient (type II and III) and up to 95% of NPC cases were EBV-positive in its endemic area [ 8 , 68 , 69 , 70 ]. The mechanism of EBV infection in NPC development through carcinogenesis, escape immunosurvilence, epigenetic alteration, and enabling the survival of the tumour has been clearly reviewed in a past study [ 71 ].…”

Section: Npc Diagnostic Biomarkersmentioning

confidence: 99%

Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma

Siak

Khoo

Leong

et al. 2021

Cancers

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Nasopharyngeal carcinoma (NPC) is an epithelial malignancy that shows a remarkable ethnic and geographical distribution. It is one of the major public health problems in some countries, especially Southern China and Southeast Asia, but rare in most Western countries. Multifactorial interactions such as Epstein–Barr virus infection, individual’s genetic susceptibility, as well as environmental and dietary factors may facilitate the pathogenesis of this malignancy. Late presentation and the complex nature of the disease have led it to become a major cause of mortality. Therefore, an effective, sensitive, and specific molecular biomarker is urgently needed for early disease diagnosis, prognosis, and prediction of metastasis and recurrence after treatment. In this review, we discuss the recent research status of potential biomarker discovery and the problems that need to be explored further for better NPC management. By studying the aberrant pattern of these candidate biomarkers that promote NPC development and progression, we are able to understand the complexity of this malignancy better, hence positing our stands better towards strategies that may provide a way forward to the discovery of more reliable and specific biomarkers for diagnosis and targeted therapeutic development.

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“…According to the statistics report of nasopharyngeal carcinoma (NPC) in 2018, more than 70% of new cases are in east and southeast Asia, with an age-standardized rate (world) of 3.0/100,000 in China to 0.4/100,000 in white populations (Bray et al, 2018). The etiology of NPC is multifactorial and is widely suspected to be complex interactions of genetic predisposition, Epstein-Barr virus infection, and environmental factors (Paul et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of Long Non-coding RNA Linc00312 Are Associated With Susceptibility and Predict Poor Survival of Nasopharyngeal Carcinoma

Guo

Bao

Fan

et al. 2021

Front. Cell Dev. Biol.

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BackgroundLinc00312 is dysregulated in nasopharyngeal carcinoma (NPC) and participates in the initiation and progression of NPC. Our previous studies suggested that linc00312 was able to enhance the sensitivity of NPC cells to irradiation and NPC patients with higher expression of linc00312 was associated with better short-term curative effect and overall survival. The single nucleotide polymorphisms (SNPs) of lncRNAs may influence the disease course and outcome by affecting the expression, secondary structure or function of lncRNAs. However, the role of SNPs in linc00312 on the occurrence and survival of NPC remains unknown.MethodsWe recruited 684 NPC patients and 823 healthy controls to evaluate the association between linc00312 SNPs and NPC susceptibility by using multivariate logistic regression analysis. Kaplan-Meier analysis and Cox proportional hazards regression were applied to assess the effect of linc00312 SNPs on the survival of NPC patients. The relative expression of linc00312 in NPC tissues was determined by real-time PCR. The interaction between linc00312 and mir-411-3p was explored by luciferase reporter assay. In silico prediction of the changes on linc00312 folding structure was conducted by RNAfold WebServer.ResultWe demonstrated that rs12497104 (G > A) GA genotype carriers had a higher risk than others for suffering from NPC (GA vs GG, OR = 1.437, P = 0.003). Besides, patients with rs12497104 AA genotype showed a poorer overall survival in contrast to GG genotype (AA vs GG, HR = 2.117, P = 0.011). In addition, the heterozygous carriers of rs15734 (G > A) and rs164966 (A > G) were correlated with decreased risk of NPC (GA vs GG, OR = 0.778, P = 0.031; GA vs AA, OR = 0.781, P = 0.033, respectively). We found that the three SNPs might influence the expression of linc00312 in a genotype specific feature. The local centroid secondary structure as well as the minimum free energy of linc00312 were changed following the candidate SNPs alterations. Besides, we revealed that the G to A alteration at rs12497104 disrupted the binding between mir-411-3p and linc00312.ConclusionOur results indicated genetic polymorphisms of linc00312 might serve as potential biomarkers for NPC carcinogenesis and prognosis.

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Nasopharyngeal carcinoma: understanding its molecular biology at a fine scale

Cited by 37 publications

References 77 publications

Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013

Association of Ambient Air Pollution with Nasopharyngeal Carcinoma Incidence in Ten Large Chinese Cities, 2006–2013

Current Status and Future Perspectives about Molecular Biomarkers of Nasopharyngeal Carcinoma

Genetic Polymorphisms of Long Non-coding RNA Linc00312 Are Associated With Susceptibility and Predict Poor Survival of Nasopharyngeal Carcinoma

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