Nasopharyngeal carcinoma: Result of treatment with cis-diamminedichloroplatinum II, 5 fluorouracil, and radiation therapy

Atichartakarn, Vichai; P, Kraiphibul; Clongsusuek, P; Pochanugool, L; Kulapaditharom, Boonchu; Ratanatharathorn, V.

doi:10.1016/0360-3016(88)90261-1

Cited by 43 publications

(6 citation statements)

References 31 publications

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“…In adults with NPC, Atichartakarn et al (29), Bachouchi et al (30) and Onat et al (31) reported better survival with neoadjuvant CT and RT. Several studies also have tested neoadjuvant cisplatin-based CT in paediatric NPC.…”

Section: Discussionmentioning

confidence: 97%

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

Bakkal¹,

Kaya²,

Berberoĝlu

et al. 2006

International Journal of Clinical Practice

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The purpose of this study was to evaluate the role of combined modality treatment in patients with paediatric nasopharynx cancer (NPC). Forty-six patients with paediatric NPC were retrospectively analysed. Forty-four of 46 patients received combined modality treatment. Five-year overall survival and progression-free survivals were 70% and 72% for the whole group, and only three of 46 patients had loco-regional relapse. Complete remission was obtained in 18 of 45 patients (40%), and the overall survival (94% vs. 62% and 19%, p = 0.0009) and disease-free survivals (93% vs. 70% and 16%, p = 0.0002) were significantly better in complete responders when compared with the patients who had partial response or stable disease. The 5-year overall survival and disease-free survivals of the patients who received neoadjuvant chemotherapy (CT) and radiotherapy (RT) followed by CT were superior to the other groups (77% and 80%, respectively). The number of total CT cycles (p = 0.0001), nodal stage (p = 0.05) and treatment response (p = 0.0009) were significant prognostic factors for overall survival. The treatment type (p = 0.02), the number of total CT cycles (p = 0.0006), nodal stage (p = 0.05) and treatment response (p = 0.0002) were found as significant prognostic factors for disease-free survival. The survival of patients receiving six or more CT cycles was also significantly better than that of patients receiving less than six cycles (p = 0.0001). In patients with locally advanced paediatric NPC, CT should be added to RT to improve outcome. However, a standard protocol is yet to be identified, and further studies evaluating the addition of interferon or immunotherapy to CT and RT shall be performed.

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Section: Discussionmentioning

confidence: 97%

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

Bakkal¹,

Kaya²,

Berberoĝlu

et al. 2006

International Journal of Clinical Practice

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“…The use of chemotherapy in combination with radiation therapy in the treatment of nasopharyngeal carcinoma has been introduced in an attempt to reduce locoregional tumoral failure rates and systemic failure rates observed in patients with locoregionally advanced disease treated with radiation therapy alone, despite improved initial locoregional tumoral response rates [10][11][12][17][18][19]43,45]. Although the most effective chemotherapy regimens to be used and their proper timing with radiation therapy remain to be determined [46], improved locoregional tumoral response rates, reduced locoregional tumoral failure rates, and reduced systemic failure rates [46][47][48][49][50][51][52][53] as well as improved overall and progression-free survival [48] have been reported with cisplatincontaining neoadjuvant and concurrent combination chemotherapy regimens. In this study, the addition of chemotherapy correlated with a lower systemic failure rate and an improved metastases-free survival.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal carcinoma in childhood and adolescence

Serin

Erkal

Elhan

et al. 1998

Med. Pediatr. Oncol.

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“…Neoadjuvant chemotherapy was tried to reduce tumor burden before RT and to eradicate micro-metastases. Several phase II trials showed high overall response rate of cisplatin-based combination chemotherapy ranging from 75% to 90% [ 18 19 20 ]. However, prospective randomized trials failed to demonstrate improvement in survival [ 21 22 23 ].…”

Section: Discussionmentioning

confidence: 99%

Patterns of care for patients with nasopharyngeal carcinoma (KROG 11-06) in South Korea

et al. 2015

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PurposeTo investigate the patterns of care for patients with nasopharyngeal carcinoma (NPC) in South Korea.Materials and MethodsA multi-institutional retrospective study was performed (Korean Radiation Oncology Group [KROG] 11-06) on a total of 1,445 patients from 15 institutions.ResultsOf the 1,445 patients, more than half were stages III (39.9%) and IV (35.8%). In addition to patterns of care, we also investigated trends over time with the periods 1988-1993, 1994-2002, and 2003-2011. The frequencies of magnetic resonance imaging and positron emission tomography-computed tomography were markedly increased in the third period compared to previous 2 periods. Concurrent chemoradiation (CCRT) was performed on 894 patients (61.9%), neoadjuvant chemotherapy on 468 patients (32.4%), and adjuvant chemotherapy on 366 patients (25.3%). Of stage II-IV patients, CCRT performed on 78.8% in 2003-2011 compared to 15.0% in 1988-1993. For patients treated with CCRT, cisplatin was the most commonly used agent in 81.3% of patients. Over the periods of time, commonly used radiotherapy (RT) techniques were changed from 2-dimensional RT (1988-1993, 92.5%) to 3-dimensional RT (2003-2011, 35.5%) or intensity-modulated RT (IMRT; 2003-2011, 56.5%). Median RT doses given to primary tumors, high-risk lymphatics, and low-risk lymphatics were 70.0 Gy, 58.1 Gy, and 48.0 Gy, respectively. Adoption of IMRT increased the dose per fraction and escalated total radiation dose.ConclusionAssessment of the patterns of care for NPC patients in South Korea demonstrated that management for NPC including diagnostic imaging, treatment regimen, RT techniques and dose schedule, advanced in accordance with the international guidelines.

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Nasopharyngeal carcinoma: Result of treatment with cis-diamminedichloroplatinum II, 5 fluorouracil, and radiation therapy

Cited by 43 publications

References 31 publications

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

The efficiency of different chemoradiotherapy regimens in patients with paediatric nasopharynx cancer: review of 46 cases

Nasopharyngeal carcinoma in childhood and adolescence

Patterns of care for patients with nasopharyngeal carcinoma (KROG 11-06) in South Korea

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