Nasopharyngeal Carcinoma in childhood: Analysis of a Series of 64 Patients treated with Combined Chemotherapy and Radiotherapy

Mouden, Karima

doi:10.19080/ctoij.2018.09.555758

Cited by 3 publications

(4 citation statements)

References 22 publications

(44 reference statements)

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“…If malignancy was suspected in a neck mass case with hard, firm or rubbery consistency, fixed supraclavicular mass, lymph node larger than 2 cm in diameter, persistent enlargement for more than two weeks, no decrease in size after four to six weeks, absence of inflammation, present of ulceration, failure to respond to antibiotic therapy, or accompanied by a thyroid mass, the patient should be referred to a head and neck surgeon for urgent evaluation and possible biopsy. 11,12 The treatment of pediatric NPC had undergone several changes in the last few decades. Until the early 1990's, patients were mostly treated by irradiation, but then chemotherapy was introduced.…”

Section: Discussionmentioning

confidence: 99%

“…Until the early 1990's, patients were mostly treated by irradiation, but then chemotherapy was introduced. 12 Besides the stage of the disease at the commencement of the therapy, the survival rates for young patients are generally better than in adults. The histological Type III which are more common in children possess a higher degree of radio sensitivity and local radio curability, in addition to their tolerability to radiation better than adults.…”

Section: Discussionmentioning

confidence: 99%

“…The histological Type III which are more common in children possess a higher degree of radio sensitivity and local radio curability, in addition to their tolerability to radiation better than adults. 12,13 Despite the low rate of relapses/recurrences, long-term follow-up is recommended, as well as endocrine monitoring, due to iatrogenic hypothyroidism. 13 Optimum treatment in children has yet to be established, however, therapeutic strategies have been adapted from established treatment guides for adults, and the core treatment for pediatric, non-metastatic nasopharyngeal carcinoma is radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

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Advanced stage nasopharyngeal carcinoma in children

Khoiria

Indrasari²,

Herdini³

et al. 2022

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Nasopharyngeal carcinoma (NPC) is common in adult and elderly population, however, the incidence among children is still very low worldwide. Due to its rarity and non-specific clinical presentation, the diagnosis in children is often delayed and misinterpreted. The difficulty in reaching the final diagnosis was related to its hidden anatomical location, raising challenges in performing endoscopy and biopsy in children to obtain the precise histopathologic feature. We reported two cases on nasopharyngeal carcinoma in children with two different peculiar complaints. The first patient was 12 years old boy who complained of multiple recurrent unilateral masses on the left neck and history of nosebleeds with an unknown history of the previous histopathology features of the neck masses obtained by complete surgical neck mass removal beforehand. The second patient was 15 years old boy with main complaint of chronic headache, accompanied by doubled vision with apparent family history of malignancy, particularly nasopharyngeal carcinoma. Based on the history of illness, physical examination, imaging, and histopathology, we concluded that both patients were diagnosed with advanced stage nasopharyngeal carcinoma with different types of histopathologic feature.</p>

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Advanced stage nasopharyngeal carcinoma in children

Khoiria

Indrasari²,

Herdini³

et al. 2022

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…Neck mass was the most prevalent impetus to seek treatment, as shown in previous studies. 7,9,19 A study in China reported that neck mass affected up to 40.9% of pediatric patients and cranial nerve involvement in 3% patients. 7 This percentage was lower than in our study (Table 2), but neck mass was the most common symptom.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr DNA in advanced pediatric nasopharyngeal cancer

Adham

Jelita

Gatot

et al. 2021

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Background Studies suggest that the most common type of nasopharyngeal carcinoma (NPC) is WHO-3, which is strongly associated with Epstein-Barr virus (EBV). Objective To assess NPC patient characteristics in a national general referral hospital in Indonesia, with regards to EBV DNA load and treatment response. Methods Twenty-three pediatric patients diagnosed with NPC were included in the study. Data collected were history, physical examination, tissue biopsy, CT scan, staging and EBV DNA load from nasopharyngeal (NP) brushing as well as blood specimens. The NP brushing, blood specimens and CT scan evaluations were done two months post-treatment. Results Pediatric patients with symptoms such as blood tinged secretion, lymph node enlargement, and nasal congestion were more likely to have higher EBV DNA loads in their NP brushings (P<0.05) (including T3 and higher). Despite significant reduction of EBV DNA load in NP brushing post-treatment, it was not associated with treatment response, as evaluated by CT scan. Conclusion Higher DNA load from NP brushings is associated with a higher tumor stage. Larger sample size and follow-up data are needed to assess the usefulness of EBV DNA load assessment in pediatric patients.

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Characteristics of Nasopharyngeal Carsinoma in Children and Adolescents in Dr. Zainoel Abidin General Hospital Banda Aceh

Setiani¹,

Fadhlia²,

Kurnia³

et al. 2019

IJNPC

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Introduction: Nasopharyngeal Carcinoma (NPC) is a malignant tumor arising from epithelial cells that cover the nasopharynx. NPC is a rare malignancy in children. The incidence of NPC varies by age, geographical and ethnic factors which indicate both genetic and environmental factors contribute to the tumor growth. NPC in children has several features different from adults. Objective: To assess characteristics of nasopharyngeal carcinoma in children and adolescents in dr. Zainoel Abidin general hospital Banda Aceh from 2014-2019. Methods: The study was conducted in dr. Zainoel Abidin general hospital Banda Aceh. This study is a descriptive with cross sectional retrospective design. The data collected from medical records of patients diagnosed with nasopharyngeal carcinoma from January 2014-September 2019. The variable including regional distribution, gender, age (between 0-25 years), histopathologic types, stage and chemotherapy regimen used. The sampling was done by total sampling method. Results: The result showed that there was 17 patients of nasopharyngeal carcinoma in children and adolescents with the highest case came from Bireuen and North Aceh district 3 (17.7%) patients, respectively. South Aceh and West Aceh distric 2 (11.8%) patients, respectively. Nasopharyngeal carcinoma mostly infected 9 (53%) male patients than 8 (47%) female with a sex ratio of 1.1 : 1. The age most affected is at the end of childhood between 17-25 years had 9 (53%) patients and between 12-16 years had 8 (47%) patients with the average age range was 17.2 years (range 13-22 years). Most of histopathologic types had found in the type of undifferentiated carcinoma (WHO type III) as many as 7 (41.1%) patients with stage IV being the most frequent 9 (53%) patients. The most widely used chemotherapy regimen is a combination of Cisplatin and Docetaxel with 10 (62.5%) patients. Conclusion: Nasopharyngeal carcinoma in children generally occur at the end of childhood with the most common type of undifferentiated carcinoma (WHO type III) and stage IV which associated with advanced locoregional disease and higher rates of distant metastasis.

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Nasopharyngeal Carcinoma in childhood: Analysis of a Series of 64 Patients treated with Combined Chemotherapy and Radiotherapy

Abstract: Background:The aim of our study is to investigate the epidemiological, clinical, radiological, therapeutic particularities of the nasopharyngeal carcinoma (NPC) in children, and to determine prognostic factors correlated with outcome and features of a series of 64 cases collected in the

Cited by 3 publications

References 22 publications

Advanced stage nasopharyngeal carcinoma in children

Advanced stage nasopharyngeal carcinoma in children

Epstein-Barr DNA in advanced pediatric nasopharyngeal cancer

Characteristics of Nasopharyngeal Carsinoma in Children and Adolescents in Dr. Zainoel Abidin General Hospital Banda Aceh

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