Nasopharyngeal carcinoma: Experience and treatment outcome with radical conformal radiotherapy from a tertiary care center in India

Kunheri, Beena; Agarwal, G. S.; Sunil, Premaletha; Nair, Anju; Pushpaja, K U

doi:10.4103/ijc.ijc_287_17

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…Correct applications of nasopharyngeal lavage can improve the efficacy of NPC radiotherapy and reduce the incidence of AEs caused by radiotherapy [20]. At present, there are a variety of nasopharyngeal lavage fluids used for patients in clinical practice, such as normal saline, potassium permanganate, medicinal H2O2, nitrofurazone fluid, sodium bicarbonate and Chinese traditional medicine [6,[21][22][23]. However, the clinical efficacy of nasopharyngeal lavage is highly heterogeneous.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study

Xiong¹,

Liu²,

Zhang³

et al. 2023

J. Cancer

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Purpose: This study aimed to evaluate and analyze the efficacy and safety of low concentration (0.15%) hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy. Methods: Patients with nasopharyngeal carcinoma from Jiangxi cancer hospital were randomly divided into two cohorts. The training cohort (n= 50) received low concentration (0.15%) hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy, and the control cohort (n= 50) received 0.02% nitrofurazone lavage fluid. The primary endpoint of the study was result of short-term efficacy. Second endpoints were assessment of the linear visual analogue scale score and the incidences rate of nasopharyngeal radiation related toxicity. Results: All patients had completed the scheduled nasopharyngeal radiotherapy except two patients in control cohort. The complete response, partial response, stable disease and disease objective response of nasopharyngeal primary tumor observed in the training cohort included 18 cases, 23 cases, 9 cases and 41 cases respectively, while in the control cohort 20 cases, 25 cases, 5 cases and 45 cases were recorded, respectively. The study showed a significant discrepancy in the incidence rate of radiation-related mucosa damage between the two. Specifically, Grade 1 and 2 included 37 cases (74.0%) in the training cohort, while in the control cohort the cases were 20 (40.0%). Grade 3 and 4 damage however reported an incidence of 26.0% and 60%, respectively, which clearly constitutes a significant statistical difference (P = 0.002). The assessment of linear visual analogue scale showed that the patients self-conscious comfortable feeling in the training cohort were significantly higher than in the control cohort (P = 0.003). Conclusions: low concentration (0.15%) hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma patients is effective and safe, and can reduce nasopharyngeal local mucosa radiation related toxicity after radiotherapy.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study

Xiong¹,

Liu²,

Zhang³

et al. 2023

J. Cancer

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“…It has a low incidence in India, except in the northeastern region of the country. 3 In Northeast India, the incidence ranges from the lowest (0.5/100 000 to 2.0/100 000 among Caucasoid) to the highest (20/100 000 among Cantonese/Zhongshan dialect Chinese). The age-adjusted rate of NPC in Kohima District of Nagaland State is 19.4/100 000.…”

Section: Introductionmentioning

confidence: 99%

“…4 The studies on the outcome and prognostic factors are from endemic high-risk regions, and there is limited data on its epidemiology and outcomes reported from southern India. 3 In this study, our aim was to document the clinical presentation of patients with NPC in our tertiary care center and to analyze the response to treatment and follow-up.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Study of Nasopharyngeal Carcinoma: Clinical and Treatment Outcome

Madhu,

Saldanha,

Bhat

et al. 2024

Journal of Health and Allied Sciences NU

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Background Nasopharyngeal carcinoma is an uncommon disease endemic to Southern China, Southeast Asia, North Africa, and the Arctic. It is uncommon in southern India, and hence its treatment outcome and prognosis are not widely studied in these areas. In this study, our primary objective was to document the clinical presentation of patients with nasopharyngeal carcinoma in southern India and to analyze the response to treatment and follow-up. Materials and Methods The study is an institutional-based retrospective study including 26 patients with histology-proven nasopharyngeal carcinoma from January 2011 to December 2017. All patients were treated with standard protocol of intensity modulated radiotherapy with concurrent chemotherapy. Data on patient demographics, clinical presentation, treatment, and follow-up were analyzed. Results The median age at presentation in our study was 53.5 years. The most common histopathology subtype was nonkeratinizing undifferentiated carcinoma (65%). Nodal metastasis was the most common clinical presentation seen in 88% of the patients. Post-treatment, distant metastasis to the iliac bone, lung, liver, and spleen was seen in two patients. Complete remission was achieved in 65%, whereas three patients developed recurrence after the completion of treatment. Five-year progression-free survival was 69%. Conclusion Nasopharyngeal carcinoma has a good response to concurrent chemoradiation. Long-term follow-up and planning surveillance strategies are essential post-treatment. Disease awareness to aid in early diagnosis and optimize management is imperative as observed from the delayed presentations in southern India.

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“…Early-stage disease is often successfully treated with RT alone with a 5-year overall survival of 87%–96% in Stages I and II. [ 1 ] Cancer patients, facing a state of immune-compromised are regarded as a highly vulnerable group in the current COVID-19 pandemic. It is recommended that cancer patients receiving antitumor treatments should have vigorous screening for COVID-19 infection and should avoid treatments causing immunosuppression or have their dosages modified in case of COVID-19 co-infection.…”

Section: Introductionmentioning

confidence: 99%

Concerns of a post-chemotherapy/radiotherapy patient of nasopharyngeal carcinoma presenting with sustained COVID-19 infection

Shweta¹,

Vig²,

Rathore³

et al. 2020

Indian J Palliat Care

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A 47-year-old patient was referred from otorhinolaryngologist with a chief complaint of hearing loss to the medical oncology department where he was diagnosed to have nasopharyngeal carcinoma (NPC). The patient was given six cycles of chemotherapy and 35# of radiotherapy. After a week of therapies, he developed a low-grade fever. He was suspected of COVID-19, but the reverse transcription polymerase chain reaction test came out to be negative. He developed urinary retention, and he was planned for suprapubic catheterization. Before the procedure, he was retested for COVID-19 which came out to be positive. This case report aims to describe the condition of a patient of NPC with COVID-19 infection and to discuss the outcome of disease in this circumstance.

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Nasopharyngeal carcinoma: Experience and treatment outcome with radical conformal radiotherapy from a tertiary care center in India

Cited by 9 publications

References 18 publications

Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study

Efficacy and safety of low concentration hydrogen peroxide as nasopharyngeal lavage fluid in the treatment for nasopharyngeal carcinoma radiotherapy: a pilot cohort study

A Retrospective Study of Nasopharyngeal Carcinoma: Clinical and Treatment Outcome

Concerns of a post-chemotherapy/radiotherapy patient of nasopharyngeal carcinoma presenting with sustained COVID-19 infection

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