Nasopharyngeal carcinoma: clinical trends

Indudharan, R; Valuyeetham, K. A.; Thirumalairaj, Kannan; Sidek, Dinsuhaimi

doi:10.1017/s0022215100138460

Cited by 14 publications

(10 citation statements)

References 8 publications

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“…A similar bimodal curve was shown in other populations of intermediate incidence of NPC (Ellouz et al, 1978;Jamal, 1991). In contrast, no such bimodal age incidence curve was noticed in populations with a high incidence rate of NPC including Hong Kong (Sham et al, 1990), Malaysia (Indudharan et al, 1997) and in Chinese populations in China, Singapore and Hong Kong (Muir et al, 1987) (Table IV).…”

Section: Discussionsupporting

confidence: 68%

Presentation and epidemiology of nasopharyngeal carcinoma in Jordan

Kamal

Samarrai

1999

J. Laryngol. Otol.

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A retrospective study, which highlights some of the aspects of nasopharyngeal carcinoma (NPC) as seen in a large hospital for 20 years in Jordan, was performed. Collected data showed that NPC accounted for one per cent of all malignant tumours during the period. The present series showed an age range from six to 89 years old with a mean of 39.5 years. There was a bimodal peak at presentation at 16 to 20 and 46 to 50 years. A high incidence of childhood NPC was also noticed (two per cent of all childhood malignant tumours). The difficulty in early diagnosis urges for better awareness of the tumour especially among general practitioners. The tumour is still detected at an advanced stage with 34 per cent metastasis most frequently to bone. The study stresses the importance of full ENT examination in cases of persistent middle ear disease, recurrent or persistent nasal symptoms or headache, or neck swelling; and routine bone scanning for all cases with NPC. There is a need for prospective studies of the causal relationship of NPC to environmental factors including Epstein-Barr (EB) virus as well as occupational and domestic hazards.

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Section: Discussionsupporting

confidence: 68%

Presentation and epidemiology of nasopharyngeal carcinoma in Jordan

Kamal

Samarrai

1999

J. Laryngol. Otol.

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“…from Nigeria and Suzina et al . in another Malaysian study, respectively [ 9 , 28 , 32 ]. In general, the frequency of aural symptoms at presentation in this study (tinnitus- 15% and hearing impairment- 23.3%), is comparable to those observed by Indudharan et al .…”

Section: Discussionmentioning

confidence: 99%

“…In general, the frequency of aural symptoms at presentation in this study (tinnitus- 15% and hearing impairment- 23.3%), is comparable to those observed by Indudharan et al . in their study, tinnitus and hearing impairment occurred in 12.3% and 18% of patients respectively [ 9 ]. Based on histological sub types, nonkeratinizing nasopharyngeal carcinoma (NK-NPC) showed the highest frequency of 94.5% in this study similar to figures of 94.6% in a recent study by Yates et al .…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study

Ogun¹,

Olusanya²,

Akinmoladun³

et al. 2020

PAMJ

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Introduction nasopharyngeal carcinoma is relatively common in our environment. It is one of the most difficult malignancies to diagnose at an early stage. The aim of the study was to determine the clinical features, clinical disease stage of nasopharyngeal carcinoma at presentation and at diagnosis as well as the histologic types at the University College Hospital, Ibadan, Nigeria. Methods this was a ten year retrospective study of all histologically confirmed nasopharyngeal carcinoma between January 2007 to December 2016 using clinical and pathology records and files. Results there were 73 cases. The male: female ratio was 1.7. The age of patients ranged from 12 to 80 years with a mean age of 39 ± 16 years. The median age at diagnosis was 40 years. The peak age group of occurrence was 40-49 years. The most common symptoms were namely epistaxis in 67.1% of patients at presentation, neck mass/swelling (64.4%) and nasal mass/obstruction (63.0%). Majority (54.8%) of the patients presented late with stage 3 or 4 disease. Most (94.5%) of the tumours were of the non-keratinizing squamous cell carcinoma subtype. The keratinizing and basaloid variants accounted for 4.1% and 1.4% of the tumours respectively. Conclusion vague, non-specific symptoms make patients present at late stages of the disease, making it almost impossible to attempt cure. The dominant histopathological type is non-keratinizing squamous cell carcinoma and resembles that seen in most parts of Nigeria and endemic areas of the world.

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“…One retrospective study of the clinical presentation of 122 patients (almost all being Malay or Chinese) with confirmed nasopharyngeal carcinoma shows the frequency of occurrence of clinical features as presenting complaints 5 . Neck swelling was the presenting complaint in 66 per cent of these patients, epistaxis in 31 per cent, and decreased hearing in 22 per cent.…”

Section: Discussionmentioning

confidence: 99%