Nasolacrimal duct obstruction as an important cause of epiphora

Avdagic, Ema; Phelps, Paul O.

doi:10.1016/j.disamonth.2020.101043

Cited by 29 publications

(29 citation statements)

References 16 publications

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“…Primary obstruction seems to be associated with infections. 45 Causes of secondary Nasolacrimal duct disease obstruction include inflammatory disease such as sarcoidosis, granulomatosis with polyangiitis, Sjögren disease, orbital inflammatory pseudotumor, and IgG4-related disease. [46][47][48] Most nasolacrimal lesions present with high T2 signal intensity, so low T2 signal with bone erosion suggests granulomatosis with polyangiitis.…”

Section: Nasolacrimal Duct Diseasementioning

confidence: 99%

Autoimmune disease of head and neck, imaging, and clinical review

et al. 2022

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Autoimmune disease of the head and neck (H&N) could be primary or secondary to systemic diseases, medications, or malignancies. Immune-mediated diseases of the H&N are not common in daily practice of radiologists; the diagnosis is frequently delayed because of the non-specific initial presentation and lack of familiarity with some of the specific imaging and clinical features. In this review, we aim to provide a practical diagnostic approach based on the specific radiological findings for each disease. We hope that our review will help radiologists expand their understanding of the spectrum of the discussed disease entities, help them narrow the differential diagnosis, and avoid unnecessary tissue biopsy when appropriate based on the specific clinical scenarios.

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Section: Nasolacrimal Duct Diseasementioning

confidence: 99%

Autoimmune disease of head and neck, imaging, and clinical review

et al. 2022

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“…Chronic dacryocystitis is the most common disorder in the lacrimal duct system and causes approximately 3% of total ophthalmologic clinic visits in polyclinic ( Amin et al, 2013 ; Avdagic and Phelps 2020 ). Characterized by the symptoms of persistent epiphora and mucopurulent discharge, chronic dacryocystitis seriously affects patients’ quality of life ( Taylor and Ashurst 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis

Liu

Zhang

et al. 2022

Front. Genet.

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This study was designed to identify differently expressed circular RNAs (circRNAs) and investigate their potential roles in lacrimal sacs from patients with chronic dacryocystitis. The lacrimal sac samples of three chronic dacryocystitis patients and three control subjects were collected for RNA sequencing after ribosomal RNA was depleted. Differently expressed circRNAs and messenger RNAs (mRNAs) were used for co-expression analysis. CircRNA-microRNA (miRNA)-mRNA interaction network were also established by miRanda software. Meanwhile, pathway and functional enrichment analysis were conducted for the down- and up-regulated mRNAs in the circRNA-mRNA co-expression network. The expression levels of circRNAs and mRNAs in chronic dacryocystitis and control samples were validated by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). In all the 3,909 circRNAs predicted through RNA sequencing, 25 circRNAs (20 up-regulated and 5 down-regulated) expressed differently in chronic dacryocystitis samples. Besides, there identified 1,486 differentially expressed mRNAs. Of these differently expressed circRNAs and mRNAs, eight were validated by qRT-PCR, including MYH2, DSP, CD27, CCL5, FN1, has_circ_0004792, has_circ_0001062, and has_circ_0115476. Gene Ontology (GO) analysis indicated that the majority of altered mRNAs in this co-expression network were involved in immune system processes and meanwhile Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that these altered expressed mRNAs were also amplified in bacterial invasion of epithelial cells, both of which were thought to be involved in the pathogenesis of chronic dacryocystitis. In the circRNA-miRNA-mRNA interaction network, six circRNAs were found to be related to Th1 and Th2 cell differentiation, which was closely associated with the development of chronic dacryocystitis. This study identified statistically significant differences between circRNAs and mRNAs of lacrimal sac samples of chronic dacryocystitis patients and control individuals and provides novel insight into the regulatory mechanism of circRNAs, miRNAs, and mRNAs in the pathogenesis of chronic dacryocystitis.

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“…It has been described that, in most cases, lacrimal duct obstruction is due to an alteration in the drainage of the lacrimal sac, which is why such cases of epiphora, or sac infection can be resolved by DCR 3 .…”

Section: Introductionmentioning

confidence: 99%

Endoscopic dacryocystorhinostomy. Results in 172 patients

Pablos-Buitrón¹,

Martínez-Morán²,

Lage-Fernández³

et al. 2021

RMOE

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Introduction: Dacryocystorhinostomy is the technique of choice for the treatment of lower lacrimal duct obstruction and recurrent dacryocystitis. Although open surgery has the highest success rates, nowadays endoscopic techniques offer advantages in terms of duration of surgery, simplicity of the technique, reproducibility, absence of scarring, and reduction of discomfort for the patient, with a high success rate. Currently, endoscopic dacryocystorhinostomy is the chosen technique in the Hospital Universitario de A Coruña. Objective: The data of the surgeries performed for 3 years have been collected with the objective of analyzing the results comparing them with those described in the literature. Method: We analyzed the results of 172 patients with a total of 220 endoscopic dacryocystorhinostomies performed between January 2014 and March 2017. Results: According to the patency test, the success rate was 83.5%, and only 12.7% required reoperation. Conclusions: Endoscopic dacryocystorhinostomy is currently the preferred technique for ophthalmologists and otorhinolaryngologists for the treatment of chronic lacrimal obstruction. Its success rates are high, and it offers multiple advantages over the open technique.

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Nasolacrimal duct obstruction as an important cause of epiphora

Cited by 29 publications

References 16 publications

Autoimmune disease of head and neck, imaging, and clinical review

Autoimmune disease of head and neck, imaging, and clinical review

Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis

Endoscopic dacryocystorhinostomy. Results in 172 patients

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