Nasal specific IgE correlates to serum specific IgE: First steps towards nasal molecular allergy diagnostic

Abstract

relevance for the future improvement of clinical diagnostics, especially in children with allergic airway disease.

Advances and highlights in allergic rhinitis

“…AR and allergic asthma patients may profit from an earlier accurate local diagnosis before the disease is systemically detectable 36 . In this respect, Gökkaya and colleagues 37 have adopted the Immuno Solid‐phase Allergen Chip (ISAC) to measure aeroallergen‐specific IgE in nasal fluid, which might be the first step toward nasal molecular allergy diagnostic. The NAC has always been regarded as a useful tool for the diagnosis of AR and LAR and therefore might serve to design and monitor allergen immunotherapy 38 .…”

Nasal lavage fluid sIgE levels in differential diagnostics of allergic rhinitis

“…A 2020 study by Gökkaya et The positive predictive value of nasal sIgE was 0.97 and that of serum sIgE was 0.96, whereas the negative predictive values were 0.82 and 0.92, respectively. As a possible cause of this lower sensitivity, the authors suggested the lack of manufacturers' instructions in terms of the optimal use of microarrays for nasal secretion specimens [23].…”

Akupunktur bei saisonaler allergischer Rhinitis: Studie zeigt positive Effekte auf Entzündungsparameter

“…Die vorliegende Studie geht in vorbildlicher Art und Weise das Thema der evidenzbasierten Medizin an. Der Einbezug des Nasensekretes als Biomarkerquelle ist hoch innovativ [1] und könnte insbesondere bei Entzündungsprozessen der oberen Nasenwege die zukunftsweisende Biomarkerquelle sein [2]. Eine auch von den Autoren diskutierte Limitation besteht in der geringen Anzahl der Teilnehmenden.…”