Nasal Smear Eosinophil CountVs AEC of Patients diagnosed with Allergic Rhinitis Attending a Tertiary Care Hospital &amp;the Effect of Treatment with a TopicalSteroid Nasal Spray on theSame

Shetty, Shreepad S; Rai, Dr.Sheetal; s, Dr Gangadhara Somayaji k; Zameel, A

doi:10.9790/0853-13197172

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…7 Among 60 children, running nose was the most common symptom accounting for 90% of cases followed by nasal obstruction (83.3%). Similar results were seen in the study by Shetty SS et al and Kumar N et al 8,10 Nasal eosinophil and blood eosinophil count was done in all 60 cases and nasal eosinophil count of >10 cells/hpf is consider positive as per IAP recommendation. Many studies have taken different cut off values.…”

Section: Resultssupporting

confidence: 86%

Study of eosinophil count in nasal smear and peripheral blood smear in children with allergic rhinitis

Sudha

Kumar

2019

Int J Contemp Pediatr

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Background: Allergic respiratory disorders are the common cases seen in Pediatrics OPD. With an appropriate history and detailed examination, the diagnosis usually may not be problematic and routine investigations may not contribute much for the final diagnosis but may help in ruling other possibilities. The objectives of this study were done to know the eosinophil counts in nasal and blood smear and to assess the feasibility of nasal cytogram which is simple, economical and reliable investigation in patients of allergic respiratory disorders.Methods: A prospective clinical correlation study conducted in outpatient visiting Mysore Medical College and Research Institute, Cheluvamba hospital Department of Pediatrics and ENT Department KR hospital. 60 children of age group between 2 to 18 years were selected to estimate the eosinophil count in nasal and peripheral smear in allergic rhinitis. All allergic rhinitis cases based on clinical signs and symptoms were selected and investigated for nasal and blood eosinophilia. The nasal and blood eosinophilia were compared with each other and the clinical findings of allergic rhinitis were studied.Results: In this study peak age incidence is between 6-10 years and there is equal gender distribution. Seasonal variation and pollen allergens were the most common risk factors for allergic rhinitis. Running nose and the nasal obstruction were the most common symptoms in children with allergic rhinitis followed by sneezing and itching. One tenth of the children with allergic rhinitis had bronchial asthma. Nasal eosinophilia contributes to the diagnosis of allergic rhinitis as compared blood eosinophilia. Mild intermittent variety of allergic rhinitis was the most common form of allergic rhinitis.Conclusions: Among various risk factors for allergic rhinitis, seasonal variation and pollen allergens have significant association with the severity of allergic rhinitis. Among various symptomology, only itching had a significant relation to the severity of allergic rhinitis.

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Section: Resultssupporting

confidence: 86%

Study of eosinophil count in nasal smear and peripheral blood smear in children with allergic rhinitis

Sudha

Kumar

2019

Int J Contemp Pediatr

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Measuring inflammation in patients with allergic rhinitis using different biomarkers

Hamad¹,

Jansson²,

Rahman³

et al. 2020

JZS

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Allergic rhinitis is an inflammatory disease affecting the mucosal lining of the nose of individuals of all ages. The allergen in the air involves‏ attaching by Immunoglobulin E that causes the release of inflammatory chemicals from mast cells. This study aimed to measure the serum level of biomarkers and to determine the correlation between them in mediating activate cell in patients with AR. In this study, blood samples were taken from 88 AR patients and 88 healthy controls (HC) Symptom score was measured using the SNOT-22 questionnaire and blood sample was analyzed for eosinophil counts (B-Eos) using optical flow cytometry, IgE by electrochemiluminescence immunoassay, as well as eosinophilic cationic protein, anti-alpha smooth muscle actin (anti-SMA), cyclooxygenase- 2 (COX-2R), phosphatase and tensin (PTEN) homolog and Tryptase Alpha/Beta 1 (TPSABI) by ELISA. B-Eos, IgE, ECP, anti-SMA, and symptom scores were significantly higher in AR patients than in HC. As a result, we found that there was correlation between B-Eos and ECP (r = 0.66, p = 0.001). There was also a correlation between IgE and symptom score (r=0.64, p=0.01). COX-2 also correlated with symptoms score (r = 0.52, p = 0.04). There was a positive correlation between phosphatase and tensin homolog and TPSAB1 (r = 0.76, p<0.001) and PTEN and ECP (r = 0.53, p = 0.03). In conclusion, we realized that in allergic rhinitis, the airway inflammation was characterized by high numbers of eosinophil, IgE, ECP and anti-SMA. B- Eos, IgE and COX-2 were related to symptom scores. The study highlights the importance of systemic inflammation in AR.

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Nasal Smear Eosinophil CountVs AEC of Patients diagnosed with Allergic Rhinitis Attending a Tertiary Care Hospital &the Effect of Treatment with a TopicalSteroid Nasal Spray on theSame

Cited by 2 publications

References 6 publications

Study of eosinophil count in nasal smear and peripheral blood smear in children with allergic rhinitis

Study of eosinophil count in nasal smear and peripheral blood smear in children with allergic rhinitis

Measuring inflammation in patients with allergic rhinitis using different biomarkers

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