Purpose: The aim of this study is to evaluate the effects of nasal septum deviation on the pharyngeal airway and cervico-craniofacial measurements on cephalometrics. Methods: The present study examines the skeletal and functional relationship of airway and septum deviation on the panoramic and cephalometric images of 50 patients with indication of orthodontic treatment, who were refeered to XXXXX University Faculty of Dentistry Departments of Pedodontics and Orthodontic for various reasons. Material of the study consists of 50 patients, including 25 patients (11 females and 9 males) with nasal septum deviation and 25 (12 females and 8 males) control group individuals without nasal septum deviation (23 females and 17 males; mean age: 10.1 ± 0.7 years). Results: The obtained data were evaluated using SPSS (21.0) package program. Regarding the data analysis, Mann-Whitney U Test Statistics was used for the analysis of two-variable data. (P>0.05). The difference between the groups was statistically significant (p<0.05) in the group with nasal septum deviation with regard to nasopharynx (af-pf1), vertical airway length (Eb-pm), and cervical colon curvature (OPT/CVT). Conclusion: Orthodontic patients detected with a nasal septum deviation of 4 mm and more on their panoramic radiographs are susceptible of various pharyngeal airway and cranio-cervical postural changes.