Nasal route for antibiotics delivery: Advances, challenges and future opportunities applying the quality by design concepts

Mardikasari, Sandra Aulia; Sipos, Bence; Csóka, Ildikó; Katona, Gábor

doi:10.1016/j.jddst.2022.103887

Cited by 7 publications

(3 citation statements)

References 204 publications

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“…Intranasal delivery of antibiotics faces, however, numerous challenges, particularly in relation to drug stability. Several lines of study are now being explored in an attempt to expand the range of antibiotics for intranasal delivery [30]. Amoxicillin intranasal delivery was primarily used in our study to reduce stress and disturbance in young pups by having an additional route of administration.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses

et al. 2023

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Emerging evidence suggests differential effects of therapeutic antibiotics on infant T cell responses to pathogens. In this study, we explored the impact of the treatment of mouse infants with amoxicillin and the human milk-derived antimicrobial HAMLET (human alpha-lactalbumin made lethal to tumor cells) on T cell responses to Streptococcus pneumoniae. Lung cells and splenocytes were isolated from the infant mice subjected to intranasal administration of amoxicillin, HAMLET, or a combination of HAMLET and amoxicillin, and cultured with S. pneumoniae to measure T cell responses. After in-vitro stimulation with S. pneumoniae, lung cells from amoxicillin- or amoxicillin plus HAMLET-treated mice produced lower levels of Th17 (IL-17A), but not Th1 (IFN-γ), cytokine than mice receiving HAMLET or PBS. IL-17A/IFN-γ cytokine levels produced by the stimulated splenocytes, on the other hand, revealed no significant difference among treatment groups. Further analysis of T cell cytokine profiles by flow cytometry showed that lung CD4+, but not CD8+, T cells from amoxicillin- or HAMLET plus amoxicillin-treated mice expressed decreased levels of IL-17A compared to those from HAMLET-exposed or control mice. Collectively, these results indicate that exposure of infant mice to amoxicillin, but not HAMLET, may suppress lung Th17 responses to S. pneumoniae.

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Section: Discussionmentioning

confidence: 99%

Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses

et al. 2023

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“…Thus, healthcare providers must exercise caution when prescribing intranasal antibiotics, ensuring proper dosing and closely monitoring patients to mitigate the potential toxic effects. 41 4.1.2. Antimicrobial APIs.…”

Section: Active Pharmaceutical Ingredients (Apis)mentioning

confidence: 99%

“…Local side effects may include nasal irritation, dryness, or even bleeding. Thus, healthcare providers must exercise caution when prescribing intranasal antibiotics, ensuring proper dosing and closely monitoring patients to mitigate the potential toxic effects …”

Section: Adverse Effects Due To Active Pharmaceutical Ingredient Exci...mentioning

confidence: 99%

Nasal Drug Delivery System and Devices: An Overview on Health Effects

Katare,

Pawar Medhe,

Nadkarni

et al. 2024

ACS Chem. Health Saf.

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For centuries, intranasal administration has been a perennial fascination for humanity. In recent times, the realm of nanotechnology-based biomaterials has witnessed a notable resurgence. At its epicenter is the concept of "nose-to-brain" delivery, a pivotal strategy within the pharmaceutical landscape aimed at circumventing the challenges of first-pass metabolism and the reticular endothelium system. This innovative approach spans a spectrum of domains, encompassing drug delivery, diagnostics, theranostics, photothermal and photodynamic therapies, bioengineering, and biomedical engineering. To overcome its multifaceted challenges, the pioneering development of novel formulations is paramount, utilizing the potential of mucoadhesive polymers, sol− gel techniques, pH-dependent absorption, and advanced methodologies. The evolution of excipient technologies has, however, raised concerns surrounding nasal irritation, rapid drainage, and systemic toxicity, affecting both established and emerging formulations. Furthermore, the growing interest in comprehending, evaluating, and documenting the toxicity profiles of nanomaterials stems from their vast range of applications across industries. It sheds light on the various toxicological implications arising from the myriad variables in dosage form formulations, including the role of excipients. It is crucial to note that the mishandling of devices designed for nasal formulation administration can significantly contribute to toxicity concerns. Given these notable developments, this comprehensive review aims to provide an exhaustive examination of current knowledge regarding the physiological consequences of intranasal drug delivery systems within the human body.

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Tissue-based in vitro and ex vivo models for nasal permeability studies

Porfiryeva,

Sosnik

2024

Concepts and Models for Drug Permeability Studies

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Nasal route for antibiotics delivery: Advances, challenges and future opportunities applying the quality by design concepts

Cited by 7 publications

References 204 publications

Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses

Treatment of Mouse Infants with Amoxicillin, but Not the Human Milk-Derived Antimicrobial HAMLET, Impairs Lung Th17 Responses

Nasal Drug Delivery System and Devices: An Overview on Health Effects

Tissue-based in vitro and ex vivo models for nasal permeability studies

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