Nasal Provocation Test in the Diagnosis of Allergic Rhinitis

Nasal allergen challenge studies of allergic rhinitis: a guide for the practicing clinician

“…The starting or lowest allergen concentration can be determined by the size of the wheal measured during skin testing, either 1/100 of the concentration that resulted in a positive skin test result or the lowest concentration of a standardized dilution curve. 19 Increasing concentrations of allergen are administered until the participants meet a prespecified qualifying symptom level, at which point the participant is eligible for the NAC at this concentration. Alternatively, if a nontitrated challenge procedure is to be followed, one can proceed directly to the one-time allergen delivery determined by the protocol.…”

Stellenwert der nasalen Provokation bei Hausstaubmilbenallergie

“…Die Überein-stimmungsrate der Ergebnisse wird mit 90 % angegeben. Im direkten Vergleich der beiden Provokationsrouten zeigten sich bei positiver Reaktion Symptome bei der konjunktiven Applikation später (nach 5 min im Vergleich zu 1 min nach NPT), dann allerdings in einem stärkeren Ausmaß, wobei auch nasale Symptome auftraten [17]. …”

Genetic Aspects of Respiratory Allergy

“…The specific allergic challenge test was performed using a standardized lyophilized Dp extract by nasal and ocular in 21 patients for each methodological procedure [21]. All patients were submitted to a previous respiratory function test (pletismography using Master screen Body Jaeger®) to assure the standard safe criteria (FEV 1 ≥ 80% and FEV 1 /FVC ≥ 80).…”

“…All the patients performed skin prick tests with an aqueous extract of Dp with 5 mg/ml concentration (23 mg/ml of Der p 1, BialAristegui, Bilbao, Spain), with the dilutions of 1/1, 1/10, 1/100 and 1/1000 and negative and positive controls, according to standardized procedures [21,54] (Dreborg 1993). The concentration used for specific provocation was the minimum that induced a prick test wheal at least equal to that induced by histamine.…”

“…Both ocular and nasal symptoms were recorded after challenge test and registered filled at the 1 st and the 5 th minutes, according specific clinical score system [21,39].…”