Nasal nitric oxide in sleep-disordered breathing in children

Gut, Guy; Tauman, Riva; Greenfeld, Michal; Armoni-Domany, Keren; Sivan, Yakov

doi:10.1007/s11325-015-1189-8

Cited by 14 publications

(4 citation statements)

References 43 publications

(63 reference statements)

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“…Even the association of the eNO with the apnea-hypopnea index (AHI) is controversial. Indeed, while some studies found a strong and positive correlation between FeNO and AHI, with a r of 0.8–0.9 [23,33], or oNO and AHI ( r : 0.46) [32] and a negative one between CaNO and AHI, with a r of 0.9 [23], this was not confirmed by other studies [20,21,22,27,28,39,41].…”

Section: Resultsmentioning

confidence: 87%

Exhaled Breath Analysis in Obstructive Sleep Apnea Syndrome: A Review of the Literature

et al. 2019

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Background and Objectives: Obstructive sleep apnea syndrome (OSAS) represents an independent risk factor for cardiovascular, metabolic and neurological events. Polysomnography is the gold-standard for the diagnosis, however is expensive and time-consuming and not suitable for widespread use. Breath analysis is an innovative, non-invasive technique, able to provide clinically relevant information about OSAS. This systematic review was aimed to outline available evidence on the role of exhaled breath analysis in OSAS, taking into account the techniques’ level of adherence to the recently proposed technical standards. Materials and Methods: Articles reporting original data on exhaled breath analysis in OSAS were identified through a computerized and manual literature search and screened. Duplicate publications, case reports, case series, conference papers, expert opinions, comments, reviews and meta-analysis were excluded. Results: Fractional exhaled Nitric Oxide (FeNO) is higher in OSAS patients than controls, however its absolute value is within reported normal ranges. FeNO association with AHI is controversial, as well as its change after continuous positive airway pressure (C-PAP) therapy. Exhaled breath condensate (EBC) is acid in OSAS, cytokines and oxidative stress markers are elevated, they positively correlate with AHI and normalize after treatment. The analysis of volatile organic compounds (VOCs) by spectrometry or electronic nose is able to discriminate OSAS from healthy controls. The main technical issues regards the dilution of EBC and the lack of external validation in VOCs studies. Conclusions: Exhaled breath analysis has a promising role in the understanding of mechanisms underpinning OSAS and has demonstrated a clinical relevance in identifying individuals affected by the disease, in assessing the response to treatment and, potentially, to monitor patient’s adherence to mechanical ventilation. Albeit the majority of the technical standards proposed by the ERS committee have been followed by existing papers, further work is needed to uniform the methodology.

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Section: Resultsmentioning

confidence: 87%

Exhaled Breath Analysis in Obstructive Sleep Apnea Syndrome: A Review of the Literature

et al. 2019

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“…In contrast, Petrosyan et al 85 found increased levels of FENO and exhaled carbon monoxide in patients with OSA; FENO decreased after 1 month of CPAP treatment. Recently, in a study by Gut et al, 94 nasal NO was higher in OSA and primary snoring compared with controls, and did not correlate with disease severity.…”

Section: Search For Other Techniques and Optional Biomarkersmentioning

confidence: 88%

Biomarkers for Sleep Apnea

2017

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Obstructive sleep apnea (OSA) is a substantial medical problem with significant morbidity, both in the pediatric population and in adults. The gold standard for diagnosis and assessment of response to treatment has been overnight polysomnography. However, it is costly, time-consuming, and inconvenient to the patients. Thus, there is an emerging need for markers that would identify patients with OSA, especially those at risk for complications who require closer surveillance and more aggressive treatment. In recent years, a large number of studies have been conducted to search for the ideal biomarker in the blood and other body fluids, mainly urine, saliva, and exhaled breath. We present a literature review of current literature on biomarkers of OSA. We conclude that the ideal sole biomarker has not been found yet, but several markers have the potential to serve as screening tools; an array of markers, as well as analysis of epigenetic factors, could serve in diagnosis and in tailoring the best specific treatment for the single patient.

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“…Compared to the healthy controls, nNO is also increased in children with sleep-disordered breathing, but it is not correlated with disease severity. This is probably due to the local mechanical processes and snoring (45).…”

Section: Obstructive Sleep Apneamentioning

confidence: 99%

Is Nasal Nitric Oxide Measurement an Useful Diagnostic Tool in Respiratory Diseases?

Lucanska¹,

Peter²,

Renata³

2023

Acta Medica Martiniana

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Nasal nitric oxide (nNO), discovered in exhaled air in 1991, is produced in the nose and paranasal sinuses. This small gaseous molecule plays various roles in the organism, e.g. the first line defense through its antiviral and antimicrobial activity, stimulation of ciliary motility, regulation of pulmonary function. The measurement of nNO has become a diagnostic tool in various diagnoses, such as primary ciliary dyskinesia, allergic rhinitis, chronic rhinosinusitis, and others. In this article, we discuss the potential benefit of nNO measurement in diagnosis and monitoring of various respiratory diseases.

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Nasal nitric oxide in sleep-disordered breathing in children

Abstract: Compared to healthy controls, nNO is increased in children with SDB, but it is not correlated with disease severity. This is probably due to the local mechanical processes and snoring.

Cited by 14 publications

References 43 publications

Exhaled Breath Analysis in Obstructive Sleep Apnea Syndrome: A Review of the Literature

Exhaled Breath Analysis in Obstructive Sleep Apnea Syndrome: A Review of the Literature

Biomarkers for Sleep Apnea

Is Nasal Nitric Oxide Measurement an Useful Diagnostic Tool in Respiratory Diseases?

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