Nasal nitric oxide as a marker of sinus mucosal health in patients with nasal polyposis

Lee, John M.; McKnight, Carmen L.; Aves, Theresa; Yip, Jonathan; Grewal, Amandeep S.; Gupta, Samir

doi:10.1002/alr.21598

Cited by 38 publications

(42 citation statements)

References 31 publications

(33 reference statements)

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“…They found significantly lower levels of nNO in patients with CRSwNP compared to that in patients with CRSsNP and controls. Conversely, nNO concentrations increased significantly in patients with chronic rhinosinusitis (CRS) after endoscopic sinus surgery, this was reported by Fu, et al 16 and Lee, et al 21 studies. Fu, et al 16 showed that nNO levels was higher in CRSsNP group than that in CRSwNP group.…”

Section: Nno= Nasal Nitric Acid Crswnp= Chronic Rhinosinusitis With mentioning

confidence: 58%

“…Their results revealed that, nNO levels were increased significantly in both groups, and this increasing in nNO levels was related to better quality of life for three months postoperative. At the same time, Lee, et al 21 found a significant increase in nNO levels from baseline to one month and six months postoperatively. Furthermore, Vaidyanathan, et al 20 detected increase in the levels of nNO after two weeks of oral steroid therapy in the CRSNP.…”

Section: Nno= Nasal Nitric Acid Crswnp= Chronic Rhinosinusitis With mentioning

confidence: 82%

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Monitoring of Chronic Sinusitis Using Nasal Nitric Oxide as a Marker of Sinus Health: A Systematic Review

Kariri

Majrashi

Fagehi

et al. 2019

Int J Life Sci Pharm Res

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It was reported that, nasal nitric oxide (nNO) is continuously released in the paranasal sinuses which acts as antibacterial and antiviral agent and improves mucociliary clearance in sinuses environment. The levels of nasal nitric oxide (nNO) are significantly changed with inflammatory stimuli as well as with medical or surgical treatment for chronic sinusitis. The present systematic review is aimed at evaluating the role of nNO as biomarker for monitoring chronic sinusitis. A webbased search was conducted in MEDLINE with inclusion criteria of human studies in English language that aimed to evaluate the role of nNO as in monitoring chronic sinusitis. Study designs adoptedwereobservational studies or clinical trials with comparisons between patient with chronic sinusitis in study group and control group of patients with flu or healthy population. The outcome assessed was the level of nNO in both groups. Data were collected for characteristics of included study such as study design, sample size, mean age, type and location of sinusitis, and technique and procedures used to monitor nitric oxide. The search on the monitoring of chronic sinusitis using nasal Nitric oxide (nNO) as marker of sinus health resulted in 97 articles, of them 81 articles were irrelevant and six articles were reviews. The included studies in this review were 10 studies. Overall findings showed that significantly lower levels of Nasal NO were reported in the patients with chronic rhinosinusitis (CRS) (irrespective of nasal polyps or allergic rhinitis concomitance) compared to healthy volunteers. The lower levels of Nasal NO in chronic rhinosinusitis are related to the decreasing of NO metabolites. The nasal nitric oxide could be employed as a good biomarker for monitoring the sinus health. The lower levels of nasal NO are indicators to the incidence ofchronic sinus inflammation in patients with chronic rhinosinusitis (CRS) These lower levels of nasal nitric oxide increase significantly after sinus therapy or surgical treatment.

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Section: Nno= Nasal Nitric Acid Crswnp= Chronic Rhinosinusitis With mentioning

confidence: 58%

Section: Nno= Nasal Nitric Acid Crswnp= Chronic Rhinosinusitis With mentioning

confidence: 82%

Monitoring of Chronic Sinusitis Using Nasal Nitric Oxide as a Marker of Sinus Health: A Systematic Review

Kariri

Majrashi

Fagehi

et al. 2019

Int J Life Sci Pharm Res

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“…This bactericidal activity is considered a mechanism of preventing commonly encountered pathogens from excessively proliferating in the sinonasal tract . Interestingly, various studies have described NO levels as a potential biomarker, because the levels in the sinuses are extremely low in patients with CRSwNP, moderately low in patients CRSsNP, and markedly high in healthy patients, increasing after medical treatment and even more after surgery and also correlating with computed tomography (CT) scans and 26‐item SNOT scores …”

Section: Resultsmentioning

confidence: 99%

Future topical medications in chronic rhinosinusitis

Miyake

Bleier

2019

Int Forum Allergy Rhinol

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Background:Research has progressed rapidly in recent decades to be er understand the etiopathogenesis and management paradigms of chronic rhinosinusitis (CRS). Although oral antibiotics o en mitigate symptoms in acute CRS exacerbations, eradication of polymicrobial biofilms and multidrug-resistant bacteria remains a challenge. The goal of this review is to summarize and discuss the potential and pitfalls of topical medications in the treatment of CRS. Methods:A related literature review was performed using PubMed and Scopus, with only the English database included. Results:The main therapies were selected and separated in sections. Details regarding future topical treatments of CRS were summarized and discussed. Conclusion:The ease of access of the sinonasal mucosa positions CRS as a disease with high potential for local topical treatment. The ultimate adoption of topical agents will require continued expansion of our understanding of novel local targets in CRS as well as improved methods to deliver and retain the drug of interest at the site of activity. C 2019 ARS-AAOA, LLC.

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“…Although surgery has been shown to increase nitric oxide levels, improve quality of life for patients with CRS, and improve long‐term outcomes, the mechanism by which this is achieved is not well understood . There is not yet an established consensus on how potential perioperative therapeutic targets such as bacterial communities, biofilms, mucosal healing, and inflammatory changes should be managed.…”

mentioning

confidence: 99%

The impact of endoscopic sinus surgery on paranasal physiology in simulated sinus cavities

Jain

Kumar

Tawhai

et al. 2016

Int Forum Allergy Rhinol

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Nasal nitric oxide as a marker of sinus mucosal health in patients with nasal polyposis

Abstract: This is the first study to show that nNO levels may be a marker of sinus mucosal health following ESS in patients with polyps. This has important implications for nNO in its potential etiologic role in mediating ongoing sinus inflammation.

Cited by 38 publications

References 31 publications

Monitoring of Chronic Sinusitis Using Nasal Nitric Oxide as a Marker of Sinus Health: A Systematic Review

Monitoring of Chronic Sinusitis Using Nasal Nitric Oxide as a Marker of Sinus Health: A Systematic Review

Future topical medications in chronic rhinosinusitis

The impact of endoscopic sinus surgery on paranasal physiology in simulated sinus cavities

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