Nasal natural killer/T-cell lymphoma and its association with type “i”/<i>Xho</i>I loss strain Epstein–Barr virus in Chile

Cabrera, María Elena; Eizuru, Yoshito; Itoh, Tetsuhiko; Koriyama, Chihaya; Tashiro, Yukihiro; Ding, Shang; Nodar, Severino Rey; Akiba, Suminori; Corvalán, Alejandro

doi:10.1136/jcp.2005.034199

Cited by 20 publications

(16 citation statements)

References 35 publications

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“…The number of patients were similar to some seen in multicentre studies [2, 13, 15, 20–22, 32–36]. The present study shows that the clinical characteristics of nasal NKTCL in Peru are similar to those described in other Latin American as well as Asian and Western countries [2, 3, 6, 8, 9, 29, 30]. The treatment used in our population was according to the clinical staging, with radiotherapy only or concurrent with chemotherapy for early stages, and chemotherapy only for advanced disease, as is described in the international literature [31].…”

Section: Discussionsupporting

confidence: 88%

Predictors of survival of natural killer/T-cell lymphoma, nasal type, in a non-Asian population: a single cancer centre experience

Vásquez¹,

Serrano²,

Lopez³

et al. 2016

ecancer

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BackgroundNatural killer/T-cell lymphoma (NKTCL), part of T-cell and NK-cell neoplasms in the World Health Organisation (WHO) classification, is an aggressive lymphoma with poor prognosis more predominantly seen in Asian and South American countries. This study evaluates the factors associated with survival among patients with newly diagnosed NKTCL in Peru.MethodsInformation was abstracted from medical records (MR) for all NKTCL patients >13 years of age at the Instituto Nacional de Enfermedades Neoplasicas (INEN) between 2002 and 2011. The estimate of the survival curves was performed by the Kaplan-Meier method, and the difference was computed by the log-rank test.ResultsAround 226 MR were reviewed, 153 met the selection criteria, the median age was 40 years (14–84). The median progression-free survival (PFS) was 20 months, five year PFS was 42.6%, univariable analysis (UA) showed statistical significance (p < 0.05) for male sex, non-nasal primary site, advanced clinical stages, B symptoms, poor performance status, regional nodal involvement (RNI). In the multivariate analysis the only poor prognostic factors was primary non-nasal (Hazard ratio (HR) = 2.40, 95% confidence interval (CI) = 1.43– 4.02, P = 0.01). The median overall survival (OS) was 49 months, five year OS was 48.9%, UA showed statistical significance for non-nasal primary site, advanced clinical stages, B symptoms, lactate dehydrogenase (LDH) > normal, RNI and local tumour invasion. In the multivariate analysis, primary non-nasal was the only poor prognostic factor with HR = 2.57, 95% CI = 1.37–4.83, P = 0.03.ConclusionsIn Peru, OS of NKTCL is similar to other countries. This result suggests that non-nasal NKTCL is the only poor prognostic factor of OS and PFS.

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Section: Discussionsupporting

confidence: 88%

Predictors of survival of natural killer/T-cell lymphoma, nasal type, in a non-Asian population: a single cancer centre experience

Vásquez¹,

Serrano²,

Lopez³

et al. 2016

ecancer

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“…Our study indicated that EBV type A was predominantly found in ENKTL, similar to previous reports from Japan, Thailand, Mexico, Chile, Brazil, and Spain [13][14][15][16]. However, in Peru and the USA, type B was found in the majority of ENKTL cases [17,18].…”

supporting

confidence: 89%

Genotypic analysis and latent membrane protein 1 expression of Epstein-Barr virus in extranodal NK/T-cell lymphoma from Northern Chinese patients

Wang

Xing

et al. 2015

Arch Virol

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As the most common NK/T-cell lymphoma in Asian countries, extranodal NK/T-cell lymphoma, nasal type (ENKTL), has unique clinical features and a strong association with Epstein-Barr virus (EBV). In order to gain a preliminary understanding of the relationship between ENKTL and EBV, we performed genotypic analysis of EBV and investigated LMP1 expression in extranodal NK/T-cell lymphoma. Our study shows that ENKTL is an EBV-associated malignancy and that A, C and F are the predominant EBV genotypes in northern China. LMP1 expression is stronger in extranasal sites than nasal sites, and the expression level is strongly correlated to ENKTL and may play an important role in the development of ENKTL.

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“…This novel recombinant strain was originally described in healthy donors 17 and later in nasal NK/T-cell lymphoma. 18 Thus this current case is the first evidence that type ''i''/XhoI loss EBV strain can be found in a LELC tumor. This is an important finding since to date the presence of type ''i''/XhoI loss EBV strain has been described in lymphoid tumors but not in epithelial tumors.…”

Section: Discussionmentioning

confidence: 56%

“…Immunohistochemical stains were performed on representative formalin-fixed paraffin sections at our institution using the streptavidin-biotin-peroxidase complex technique and an automated tissue stainer (Biogenex, San Ramon, CA) with antibodies specific for keratins (AE1/AE2) (dilution 1:100, Biogenex), HMB45 (dilution 1:50, Biogenex), and EBV EBNA-1 (dilution 1:50, DAKO, Carpenteria, CA). 18 …”

Section: Histology and Immunohistochemistrymentioning

confidence: 99%

“…17 Genotype-specific Primer Sets and Probes for EBV Genotypes of EBV were examined by polymerase chain reaction (PCR) and restriction enzyme as described previously. 17,18 Briefly, for distinguishing type 1 and 2 EBV, we used primers to produce 153-bp and 246-bp fragments at EBNA-3C region, respectively. 19 The BamHI-F and the BamHI-W1/I1 regions were amplified to yield 198-bp and 205-bp fragments for the prototype F and type I, respectively.…”

Section: In Situ Hybridizationmentioning

confidence: 99%

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Epstein-Barr Virus-associated Primary Lymphoepitheliomalike Carcinoma of the Esophagus

Valbuena

Retamal²,

Bernal³

et al. 2007

Diagnostic Molecular Pathology

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Primary lymphoepitheliomalike carcinomas (LELC) of the esophagus are uncommon, with only 29 previously reported cases in the literature. Primary LELC of the esophagus is associated with Epstein-Barr virus (EBV). We herein report a 52-year-old man who presented with dysphagia and weight loss and was found to have a polypoid mass in the middle esophagus. Pathologic examination showed LELC. EBV infection was demonstrated by immunohistochemical detection of EBNA-1 in neoplastic cells and polymerase chain reaction amplification for EBNA-3C, BamHI-F, and W1/I1 regions but not by in situ hybridization by EBER-1 transcripts. EBV genotyping analysis demonstrated infection by a novel type "i"/XhoI loss recombinant strain. Although it is accepted that polymorphisms at BamHI-W1/I1 region cosegregate with polymorphisms at XhoI restriction site, this novel recombinant EBV has been identified in healthy donors and in nasal NK/T-cell lymphoma. To our knowledge, this is the first report that describes this recombinant type "i"/XhoI loss EBV strain in a primary LELC of the esophagus.

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Nasal natural killer/T-cell lymphoma and its association with type “i”/XhoI loss strain Epstein–Barr virus in Chile

Cited by 20 publications

References 35 publications

Predictors of survival of natural killer/T-cell lymphoma, nasal type, in a non-Asian population: a single cancer centre experience

Predictors of survival of natural killer/T-cell lymphoma, nasal type, in a non-Asian population: a single cancer centre experience

Genotypic analysis and latent membrane protein 1 expression of Epstein-Barr virus in extranodal NK/T-cell lymphoma from Northern Chinese patients

Epstein-Barr Virus-associated Primary Lymphoepitheliomalike Carcinoma of the Esophagus

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