Nasal Mucociliary Clearance Under Various Conditions

Sakakura, Yasuo; Ukai, Kotaro; Majima, Yuichi; Murai, Sumiko; Harada, Teruhiko; Miyoshi, Yasuro

doi:10.3109/00016488309132888

Cited by 175 publications

(103 citation statements)

References 9 publications

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“…Secondary loss of cilia and squamous metaplasia are very likely re sponsible for this. It should be remem bered that in some studies a rather slow nasal mucociliary clearance was found in 15-30% of the healthy individuals [1,15,16]. The radiation dose of our method is quite acceptable, even when mucociliary clearance is completely lacking.…”

Section: Discussionmentioning

confidence: 99%

Primary Ciliary Dyskinesia and Nasal Mucociliary Clearance

Baan

Heidendahl²,

Hollander³

et al. 1987

Respiration

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In this study, nasal mucociliary clearance is investigated in patients with primary ciliary dyskinesia, patients with other respiratory tract infections and healthy persons. Mucociliary clearance is established with a drop of albumen labelled with ^99m-Tc. From this study it appears that measurement of mucociliary clearance in the nose can serve as a reliable screening method. If a patient with respiratory tract infections shows a normal mucociliary clearance rate there is no primary ciliary dyskinesia, and a biopsy of ciliated epithelium is not necessary. If, after repeated examinations, a normal clearance rate cannot be demonstrated, a biopsy of ciliated epithelium should be taken for studying ciliary activity and ciliary ultrastructure

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Section: Discussionmentioning

confidence: 99%

Primary Ciliary Dyskinesia and Nasal Mucociliary Clearance

Baan

Heidendahl²,

Hollander³

et al. 1987

Respiration

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“…Prolonged transit times are considered to be impaired mucociliary clearance that may lead up to longterm respiratory tract diseases, sinonasal and middle ear infections [11]. There are various factors effecting mucociliary clearance time such as temperature, moisture, partial oxygen pressure , pH, cigarette and various inhalation agents; anatomic barriers as septum deviation, adenoid hypertrophy and systemic diseases such as viral infections, chronic sinusitis, chronic and allergic rhinitis, cystic fibrosis, bronchiectasis, chronic bronchitis and diabetes mellitus [2,3,12].…”

Section: Discussionmentioning

confidence: 99%

“…Mucociliary activity of the nose helps to remove foreign particles, pathogens, and toxins by transporting the mucus layer that covers the nasal epithelium towards the nasopharynx and it also helps to keep the mucosal surfaces moist by mucous gland secretions to obtain normal nasal physiology [1]. Nasal mucociliary clearance time (NMC) can be affected from some rhinological pathologies (allergic rhinitis, sinusitis, nasal polyposis), trauma, sinonasal surgery [2,3]. It has also been shown that NMC can be affected from toxins, drugs, environmental heat, smoking, pressure, pH, and so on.…”

mentioning

confidence: 99%

The Effect of Passive and Active Smoking on Nasal Mucociliary Clerarance Time

2016

Ann Clin Anal Med

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ÖzetAmaç: Bu çalışmanın amacı pasif ve aktif sigara kullanımının nazal mukosiliyer klirens süresi üzerine etkisini yaş ve cinsiyet bakımından benzer sağlıklı bireyler, pasif ve aktif sigara kullanıcılarının sonuçlarını karşılaştırarak araş-tırmaktır. Gereç ve Yöntem: Yetmiş beş hasta kriterleri karşıladı ve 3 gruba ayrıldı: 25 sağlıklı, aktif ya da pasif kullanımı olmayan olgu, 25 pasif sigara kullanıcısı ve 25 aktif sigara kullanıcısı çalışma grubunu oluşturmakta idi. Ayrıntılı anamnez, kulak burun boğaz muayenesi ve nazal endoskopi sonrasın-da nazal mukosiliyer klirens süresi ölçüldü ve karşılaştırıldı. Ayrıca, aktif sigara kullanıcısı grubunda sigara tüketim miktarı paket yıl olarak hesaplandı ve nazal mukosiliyer klirens süresi uzaması ile sigara tüketim miktarı arasın-daki korelasyon değerlendirildi. Bulgular: Ortalama nazal mukosiliyer klirens süresi pasif ve aktif sigara kullanımı olan gruplarda sağlıklı gruba göre anlamlı derecede daha uzamış olarak saptandı (p=0,0001). Pasif ve aktif sigara kullanımı olan grupların ortalama nazal mukosiliyer klirens süresi istatistiksel olarak farklı bulunmadı(p≥0,05). Aktif sigara kullanımı olan grupta sigara tüketim miktarı ile ortalama nazal mukosiliyer klirens süresinde uzama arasında pozitif korelasyon saptandı( p=0,0001,r=0.433). Tartışma: Bu ça-lışmada, pasif ve aktif sigara kullanımının nazal mukosiliyer klirens süresini uzattığı saptanmıştır. Tütüne maruziyet astım, kronik rinosinüzit ve alt solunum yolu enfeksiyonları ile ilişkilidir. Bu durum, uzamış nazal mukosiliyer klirens süresi ile ilişkili olabilir. Anahtar KelimelerPasif Sigara Kullanımı; Aktif Sigara Kullanımı; Nazal Mukosiliyer Klirens Süresi Abstract Aim: The aim of this study was to investigate the effect of passive and active smoking on NMC by comparing the results of age and sex matched healthy individuals, passive and active smokers. Material and Method: A total of 75 subjects met the criteria and were divided into three groups: control group (nonsmokers, group 1, n =25), passive smokers group(group 2, n =25), active smokers group (group 3, n =25). NMC of these subjects were measured and compared. Moreover, the amount of cigarette consumption of active smokers group were calculated as package to year and the correlation between NMC and the amount of cigarette consumption. in active smokers group were evaluated. Results: The mean NMC in passive smokers group and active smokers group were significantly longer than the control group (p=0,0001) The comparison of NMC values between the passive smokers group and the active smokers group revealed no statistically significant differences (p≥0,05). There was positive correlation between the increase in NMC and amount of cigarette consumption in the active smokers group ( p=0,0001,r=0.433). Discussion: Both active and passive smoking prolonged nasal mucociliary clearance time when they were compared with healthy controls. Tobacco exposure is associated diseases such as asthma, chronic rhinosinusitis, and lower airway infections. It may be related to the d...

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“…Increased proteases released by inflammatory mediators contribute to the ciliary damage or loss. Sakakura et al 11 suggested that the abundant and sticky mucopurulent secretions of chronic rhinosinusitis patients cause deceleration of particle transport rate and also decrease in the amount of periciliary fluid where cilia beat.…”

Section: Group 1: Chronic Rhinosinusitis Patientsmentioning

confidence: 99%

Mucociliary Function: Its Variations with Disease

Kumar¹,

Preetham²,

Feshan³

2016

An International Journal Clinical Rhinology

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Introduction: This study compares the nasal mucociliary clearance time of patients with chronic sinusitis (pre-and postoperatively) and smokers, with controls, attending the ear, nose, and throat outpatient department at Southern Railway Headquarters Hospital, Perambur, Chennai. Materials and methods:Saccharin granule was used to study mucociliary clearance as it is safe, easy, fast, and reliable. A total of 32 patients in each group were studied. In chronic rhinosinusitis patients, the test was done preoperatively and 4 weeks postoperatively. Results:The average mucociliary clearance time pre-and postoperatively in chronic rhinosinusitis patients was 29.54 ± 28.68 and 12.17 ± 5.84 respectively. Cigarette smokers had a longer mucociliary clearance time (27.63 ± 21.11) compared with beedi smokers (24.04 ± 24.93). Controls had the fastest mucociliary clearance rate of 9.67 ± 4.62 among the study subjects.Conclusion: Surgery for chronic rhinosinusitis improves both the overall symptoms of chronic rhinosinusitis and the protective functions of the nose and paranasal sinuses. Smokers had an impaired clearance rate compared with normals. As age advances, the mucociliary clearance rate becomes slower.

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Nasal Mucociliary Clearance Under Various Conditions

Cited by 175 publications

References 9 publications

Primary Ciliary Dyskinesia and Nasal Mucociliary Clearance

Primary Ciliary Dyskinesia and Nasal Mucociliary Clearance

The Effect of Passive and Active Smoking on Nasal Mucociliary Clerarance Time

Mucociliary Function: Its Variations with Disease

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