Nasal Mucociliary Clearance in Patients with Upper and Lower Respiratory Diseases

Ogino, Satoshi; Nose, Michihiro; Irifune, Morihiro; Kikumori, Hiroshi; Igarashi, Tsuyoshi

doi:10.1159/000276454

Cited by 11 publications

(9 citation statements)

References 7 publications

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“…Some studies report normal MCC in CF [15,16], others demonstrate similar abnormalities in CF and other disease groups [17,18] or impaired MCC in CF patients [19][20][21][22][23][24], leading to uncertainty as to whether any observed impairment is related to the low volume hypothesis or results from "secondary" phenomena such as inflammation. The adverse effect of inflammatory damage has been confirmed in studies of non-CF bronchiectasis [17,18], asthma [24] and chronic sinonasal disease [17,25]. The majority of CF studies have been performed in adults; sinusitis is common in this age group [26], and distinction of a primary from secondary effect is therefore difficult.…”

mentioning

confidence: 99%

Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect

McShane

Davies

Wodehouse³

et al. 2004

European Respiratory Journal

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Studies on mucociliary clearance (MCC) in cystic fibrosis (CF) have produced conflicting results. This study aimed to differentiate primary (ion transportrelated) from secondary (inflammatory) causes of delayed MCC in CF.Nasal MCC was measured in 50 children (CF, primary ciliary dyskinesia (PCD) and no respiratory disease). Nasal lavage fluid was analysed for interleukin (IL)-8 and tumour necrosis factor-a. Similar measurements were obtained in adult CF patients with and without chronic sinusitis (CS).Children with CF had neither delayed MCC nor increased levels of cytokines. Conversely, children with PCD had prolonged MCC times (all w30 min) and significantly raised levels of IL-8. CS-positive CF adults had significantly slower MCC than CS-negative subjects, but IL-8 levels were low and similar in both groups.Decreased airway surface liquid and delayed mucociliary clearance are the postulated primary mechanisms in cystic fibrosis. However, the current study reports that cystic fibrosis children have normal nasal mucociliary clearance. Abnormalities appeared in cystic fibrosis adults with symptoms of chronic sinus disease, suggesting a secondary rather than primary phenomenon. Studies to explore this mechanism in the distal, more sparsely-ciliated airways could aid an understanding of pathogenesis and the development of new treatments. Eur Respir J 2004; 24: 95-100.

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confidence: 99%

Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect

McShane

Davies

Wodehouse³

et al. 2004

European Respiratory Journal

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“…Several lines of evidence link sinusitis to tobacco exposure through its effect on nasal mucociliary function. Cigarette smoke 3 and the inhalation of nasal snuff 4 have a profound effect on nasal airway mucociliary function, demonstrated by in vivo nasal mucociliary clearance tests. Agius et al 5 showed that cotinine, a metabolite of nicotine, caused a significant decrease in the ciliary beat frequency of nasal mucosal cells in vitro.…”

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confidence: 99%

Confirmations and Surprises in the Association of Tobacco Use With Sinusitis

Lieu¹,

Feinstein²

2000

Arch Otolaryngol Head Neck Surg

111

106

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Consistent with data for other respiratory ailments, the direct use of tobacco confers a small increased risk of developing sinusitis in the adult population, but contrary to expectation, passive smoke does not. The demographic variables of sex, race/ethnicity, and educational level demonstrated unexpectedly strong associations with the prevalence of sinusitis and should be analyzed and controlled for in future studies of sinusitis.

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“…Several rhinopathic conditions may affect both morphology and function in the nasal epithelium, and result in alterations in NMC. These include personal conditions like infection, allergy, nasal obstruction, dust particles, tobacco use, aging [6,9,[19][20][21][22][23][24][25][26] , and environmental conditions like temperature, humidity, altitude and air pollution [27,28] . The effect of age on NMC is under debate.…”

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confidence: 99%

Evaluation of Nasal Mucociliary Functions with Rhinoscintigraphy in Coal Workers’ Pneumoconiosis

Peksoy

Uğur²,

Altın

et al. 2005

ORL

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Objective: To compare nasal mucociliary clearance (NMC) functions in coal workers with pneumoconiosis, coal workers without pneumoconiosis and healthy controls by using technetium-99m-labeled macroaggregated albumin rhinoscintigraphy. Methods: Sixty-five of the 86 coal workers were clinically documented as suffering from coal workers’ pneumoconiosis (CWP group). CWP workers were divided into two groups according to smoking status: 44 smokers (CWP-S) and 21 nonsmokers (CWP-NS). Twenty-one workers without pneumoconiosis (NCWP group) were similarly divided into two groups: 12 smokers (NCWP-S) and 9 nonsmokers (NCWP-NS). Thirty-three healthy male volunteers were selected for the control group [15 smokers (control-S), 18 nonsmokers (control-NS)]. The half-time (t_½) value for the clearance of the radiopharmaceutical was calculated for each patient. Results: Mean t_½ values for CWP-S, CWP-NS, NCWP-S, NCWP-NS, control-S and control-NS were 25.10 ± 7.75, 10.97 ± 3.24, 14.68 ± 4.98, 9.17 ± 3.71, 19.15 ± 5.04 and 15.08 ± 5.11, respectively (p < 0.001, Kruskal-Wallis variance analysis). Further, mean t_½ values of smokers versus nonsmokers in CWP, NCWP and control groups were compared, and it was found that although smoking prolonged nasal transport time in all three groups, the difference was significant only in the CWP group (p < 0.001, p < 0.023 and p < 0.027, respectively, Bonferroni-adjusted Mann-Whitney test). Conclusion: Our findings demonstrated a synergistic detrimental effect of smoking with coal dust exposure on nasal transport time.

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Nasal Mucociliary Clearance in Patients with Upper and Lower Respiratory Diseases

Cited by 11 publications

References 7 publications

Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect

Normal nasal mucociliary clearance in CF children: evidence against a CFTR-related defect

Confirmations and Surprises in the Association of Tobacco Use With Sinusitis

Evaluation of Nasal Mucociliary Functions with Rhinoscintigraphy in Coal Workers’ Pneumoconiosis

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