Nasal lavage levels of granulocyte‐macrophage colony‐stimulating factor and chronic nasal hypereosinophilia

Corso, Eugenio De; Baroni, Silvia; Lucidi, Daniela; Battista, Mariapina; Romanello, Matteo; Autilio, Chiara; Morelli, Renato; Nardo, Walter Di; Passàli, Giulio Cesare; Sergi, Bruno; Bussu, Francesco; Fetoni, Anna Rita; Zuppi, Cecilia; Paludetti, Gaetano

doi:10.1002/alr.21519

Cited by 35 publications

(39 citation statements)

References 34 publications

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“…Several authors have tried to distinguish nasal polyp (NP) patients based on predominant inflammatory cell type/cytokine expression; the most common classification differentiates them into eosinophilic CRSwNP and non‐eosinophilic CRSwNP . In Western countries, CRSwNP is mostly characterized by eosinophilic inflammation with a prevalence ranging between 70% and 90% according to different reports .…”

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confidence: 99%

Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end?

Corso

Lucidi

Battista

et al. 2017

Int Forum Allergy Rhinol

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Our data suggest that early identification of inflammatory patterns and associated clinical factors in patients affected by chronic nonallergic sinonasal inflammation have a prognostic value that can help to identify patients with different risks of NP development. Our data confirm that detection of nasal eosinophilic inflammation represents an early marker for identification of a more aggressive inflammatory phenotype.

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Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end?

Corso

Lucidi

Battista

et al. 2017

Int Forum Allergy Rhinol

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“…The pathogenesis of chronic hypereosinophilia in nasal mucosa is not well known. Recent findings indicated an increased transendothelial migration of eosinophils, attracted and activated by chemokines and cytokines . Eotaxin‐1 (CCL11), eotaxin‐2 (CCL24), and eotaxin‐3 (CCL26) seem to be potent and selective attractants .…”

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confidence: 99%

Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis

Perić

Sotirović

Špadijer-Mirković

et al. 2015

Int Forum Allergy Rhinol

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“…In our review of the literature, we found only one recently published study concerning the association between GM-CSF levels in nasal secretions and nasal eosinophilia. De Corso et al 21 found detectable levels of this cytokine in 34 of 70 (48.57%) patients, with an average concentration of 2.67 ± 0.8 pg/ml, whereas, only 1 out of 20 individuals in the control group showed detectable GM-CSF levels. In our study, we found detectable levels of GM-CSF in 22 of 28 patients (71.57%).…”

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confidence: 95%

Granulocyte-Macrophage Colony-Stimulating Factor Production and Tissue Eosinophilia in Chronic Rhinitis

Perić

Špadijer-Mirković

Matković-Jožin

et al. 2016

Int Arch Otorhinolaryngol

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Introduction Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a strong proinflammatory cytokine that takes part in allergic nasal inflammation as an eosinophil colony-stimulating factor. However, the role of GM-CSF in non-allergic rhinitis has not been fully explored. Objectives The aim of this investigation was to assess the concentration of GM-CSF in nasal secretions of patients with non-allergic rhinitis with eosinophilia syndrome (NARES) in comparison to patients with perennial allergic rhinitis (PAR) and healthy subjects, as well as to assess the relationship with the degree of eosinophilic inflammation and clinical characteristics of the patients. Methods Fourteen patients with diagnosis of NARES, 14 PAR patients, and 14 healthy subjects were included in this cross-sectional study. All patients underwent symptom score assessment, nasal endoscopy, allergy testing, and cytological evaluation. The concentration of GM-CSF in nasal secretions of all participants was measured by enzyme-linked immunosorbent assay (ELISA). Results We found significantly higher levels of GM-CSF in patients with NARES than in the control group (p = 0.035). The percent of eosinophils in nasal mucosa was higher in NARES patients in comparison to patients with PAR (p < 0.001) and control patients (p < 0.0001). We found positive correlations between GM-CSF levels and eosinophil counts only in NARES patients. Conclusion The concentrations of GM-CSF in nasal secretions correlate well with eosinophil counts in the nasal mucosa of NARES patients. These facts indicate a possible role of GM-CSF as a favorable marker for assessment of nasal disease severity and the degree of chronic eosinophilic inflammation in the nasal mucosa.

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Nasal lavage levels of granulocyte‐macrophage colony‐stimulating factor and chronic nasal hypereosinophilia

Cited by 35 publications

References 34 publications

Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end?

Prognostic value of nasal cytology and clinical factors in nasal polyps development in patients at risk: can the beginning predict the end?

Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis

Granulocyte-Macrophage Colony-Stimulating Factor Production and Tissue Eosinophilia in Chronic Rhinitis

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