Nasal involvement in systemic amyloidosis

Abstract

A localized amyloid deposit in the nose is extremely rare and involvement of the nose involvement in systemic amyloidosis is presented.

Primary Amyloidosis of the Nose Presenting with Refractory Epistaxis and Systemic Involvement — A Rare Phenomenon

“…The tongue may be associated with systemic disease (3). Utilizing a PubMed and Medline search, there has only been one reported case of nasal cavity involvement in systemic disease (4). The patient in this case report presented with primary systemic amyloidosis AL type involving the nasal cavity and sigmoid colon.…”

Nasopharyngeal amyloidosis: an unusual cause for epistaxis

“…There have been 28 case reports of nasal or nasopharyngeal amyloidosis deposits in the English language literature between 1928 and 2004 1 – 24 . Only three of these cases occurred secondary to systemic amyloidosis 5 , 9 , 16 . Elcock and Grimaldi reported the case of a 72-year-old woman with known Waldenstrom's macroglobulinaemia presenting with epistaxis, nasal obstruction and a mass in the nasal cavity 5 .…”

“…Elcock and Grimaldi reported the case of a 72-year-old woman with known Waldenstrom's macroglobulinaemia presenting with epistaxis, nasal obstruction and a mass in the nasal cavity 5 . Dubey et al described a 64-year-old woman with systemic primary amyloidosis presenting with increasing nasal obstruction, epistaxis and progressive widening of the dorsum of the nose 9 . In this case, anterior rhinoscopy revealed a pale, polypoid, friable mass at the level of the middle turbinate in both nasal cavities.…”

“…Thirteen out of a possible 26 articles available for review describe resection of nasal or nasopharyngeal amyloidosis 1 , 2 , 5 , 7 – 15 , 18 . Only one of the three patients with secondary amyloidosis underwent surgical resection, as the remaining patients were unsuitable for surgical intervention owing to their poor health status 5 , 9 , 16 . Earlier cases used comparatively extensive surgical methods.…”

Primary sinonasal amyloidosis

“…Plasma cell dyscrasias predispose to AL amyloid, 4 whereas, systemic amyloidosis secondary to chronic in ammatory diseases predispose to deposition of AA amyloid.…”