Nasal Intermittent Mandatory Ventilation Versus Nasal Continuous Positive Airway Pressure for Respiratory Distress Syndrome: A Randomized, Controlled, Prospective Study

Kugelman, Amir; Feferkorn, Ido; Riskin, Arieh; Chistyakov, Irena; Kaufman, Bella; Bader, David A.

doi:10.1016/j.jpeds.2007.01.032

Cited by 196 publications

(164 citation statements)

References 21 publications

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“…Kugelman et al also did not observe the occurrence of gastrointestinal complications in their study. 17 Similar facts have been described by other authors. 9,18,19 Barrington et al did not demonstrate an increased incidence of abdominal distention or food intolerance in the 54 premature infants subject to two non-invasive ventilation methods, and also did not find any cases of gastric perforation.…”

Section: Discussionsupporting

confidence: 86%

“…7 There is evidence that these impulses are induced by nIPPV, and could be responsible for recruiting more alveoli and reversing areas of pulmonary microatelectasis, which explains its success. 17 The main factor related to extubation failure, regardless of the study group, was sleep apnea, present in 41.2% of the premature infants. In the studies by Barrington et al, the occurrence of apnea constituted one of the main causes of extubation failure.…”

Section: Discussionmentioning

confidence: 93%

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Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation

Komatsu

Diniz

Ferraro

et al. 2016

Rev. Assoc. Med. Bras.

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Objective:To analyze the frequency of extubation failure in premature infants using conventional mechanical ventilation (MV) after extubation in groups subjected to nasal intermittent positive pressure ventilation (nIPPV) and continuous positive airway pressure (nCPAP). Method: Seventy-two premature infants with respiratory failure were studied, with a gestational age (GA) ≤ 36 weeks and birth weight (BW) > 750 g, who required tracheal intubation and mechanical ventilation. The study was controlled and randomized in order to ensure that the members of the groups used in the research were chosen at random. Randomization was performed at the time of extubation using sealed envelopes. Extubation failure was defined as the need for re-intubation and mechanical ventilation during the first 72 hours after extubation. Results: Among the 36 premature infants randomized to nIPPV, six (16.6%) presented extubation failure in comparison to 11 (30.5%) of the 36 premature infants randomized to nCPAP. There was no statistical difference between the two study groups regarding BW, GA, classification of the premature infant, and MV time. The main cause of extubation failure was the occurrence of apnea. Gastrointestinal and neurological complications did not occur in the premature infants participating in the study. Conclusion: We found that, despite the extubation failure of the group of premature infants submitted to nIPPV being numerically smaller than in premature infants submitted to nCPAP, there was no statistically significant difference between the two modes of ventilatory support after extubation.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 93%

Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation

Komatsu

Diniz

Ferraro

et al. 2016

Rev. Assoc. Med. Bras.

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“…Studies comparing NIPPV vs SIMV have shown promising results. Kugelman et al 45 compared NCPAP with NIPPV as a primary mode of respiratory support in preterm infants <35 weeks gestational age with RDS. NIPPV was more successful than NCPAP in decreasing the need for endotracheal intubation, and in the incidence of BPD.…”

Section: Noninvasive Ventilation Strategiesmentioning

confidence: 99%

Lung protective ventilatory strategies in very low birth weight infants

Ramanathan

Sardesai

2008

J Perinatol

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Respiratory distress syndrome (RDS) is the most common respiratory diagnosis in preterm infants. Surfactant therapy and mechanical ventilation using conventional or high-frequency ventilation have been the standard of care in the management of RDS. Bronchopulmonary dysplasia (BPD) continues to remain as a major morbidity in very low birth weight infants despite these treatments. There is no significant difference in pulmonary outcome when an optimal lung volume strategy is used with conventional or high-frequency ventilation. Lung injury is directly related to the duration of invasive ventilation via the endotracheal tube. Studies using noninvasive ventilation, such as nasal continuous positive airway pressure and noninvasive positive pressure ventilation, have shown to decrease postextubation failures as well as a trend toward reduced risk of BPD. Lung protective ventilatory strategy may involve noninvasive ventilation as a primary therapy or following surfactant administration in very preterm infants with RDS. Initial steps in the management of preterm infants may also include sustained inflation to establish functional residual capacity, followed by noninvasive ventilation to minimize lung injury and subsequent development of BPD.

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“…6 In the present study, duration A wide variety of ventilator settings have been utilized to provide SNIPPV. 12 As regards to evidence from randomized controlled trials (RCT), the work from our group [15][16][17][18] and other independent investigators 13,19,20 have shown efficacy using fairly similar ventilator guidelines. A recent study that used our SNIPPV guidelines 21 for NIPPV has also reported benefit.…”

mentioning

confidence: 99%

“…12 Primary mode SNIPPV (after early intubation and surfactant administration), in a RCT, had a significantly improved primary outcome of BPD/death, compared to the group that continued on ETT IPPV, with no difference in other common neonatal morbidities. 18 In a RCT using primary mode NIPPV (using NIPPV as first line of therapy), the infants randomized to the NIPPV group were more likely to stay extubated 13,14 and had less BPD. 13 In another RCT, primary mode NIPPV (after early intubation and surfactant administration) resulted in more successful extubation and less BPD.…”

mentioning

confidence: 99%

Extubações acidentais - será que os bebês estão tentando nos dizer alguma coisa?

Bhandari

2010

J. Pediatr. (Rio J.)

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Nasal Intermittent Mandatory Ventilation Versus Nasal Continuous Positive Airway Pressure for Respiratory Distress Syndrome: A Randomized, Controlled, Prospective Study

Cited by 196 publications

References 21 publications

Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation

Randomized controlled trial comparing nasal intermittent positive pressure ventilation and nasal continuous positive airway pressure in premature infants after tracheal extubation

Lung protective ventilatory strategies in very low birth weight infants

Extubações acidentais - será que os bebês estão tentando nos dizer alguma coisa?

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