Nasal instillation of povidone‐iodine ameliorates ongoing mucosal inflammation in a pre‐sensitized murine model of Der p1‐induced allergic rhinitis
Jae‐Yoon Kang,
Mi‐Ra Choi,
Yong Min Kim
Abstract:BackgroundInterleukin (IL)‐33, when cleaved into smaller fragments by proteases, becomes hyperactive, contributing to allergic inflammation. Povidone‐iodine (PVP‐I) is an iodine‐based compound that exhibits antimicrobial properties and inhibits proteases. This study aimed to investigate whether PVP‐I treatment inhibits IL‐33 cleavage, improves allergic rhinitis (AR) symptoms, and suppresses allergic inflammation in a mouse model.MethodsIn vitro experiments using full‐length recombinant human IL‐33 and allergen… Show more
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