2007
DOI: 10.1128/iai.01668-06
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Nasal Immunization withBurkholderia multivoransOuter Membrane Proteins and the Mucosal Adjuvant Adamantylamide Dipeptide Confers Efficient Protection against Experimental Lung Infections withB. multivoransandB. cenocepacia

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Cited by 27 publications
(35 citation statements)
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“…This is the first study that involves the use of recombinant subunit antigens to protect mice against Bcc bacteria. Previously, mice were protected from B. cenocepacia by using enriched OMPs that were administered intranasally as a nanoemulsion preparation (25,26). Both of those studies demonstrated the potential for OMPs as protective antigens but were carried out with unpurified OMP preparations, which are ill defined, rather than pure specific identified antigens.…”
Section: Discussionmentioning
confidence: 99%
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“…This is the first study that involves the use of recombinant subunit antigens to protect mice against Bcc bacteria. Previously, mice were protected from B. cenocepacia by using enriched OMPs that were administered intranasally as a nanoemulsion preparation (25,26). Both of those studies demonstrated the potential for OMPs as protective antigens but were carried out with unpurified OMP preparations, which are ill defined, rather than pure specific identified antigens.…”
Section: Discussionmentioning
confidence: 99%
“…Bacterial challenge studies were performed 2 weeks following booster vaccination, with immunosuppression by i.p. injection of 50 g of cyclophosphamide on days Ϫ1 and 4 of challenge (25). The immunized and nonimmunized mice were challenged with 4 ϫ 10 7 B. cenocepacia BC7 or B. multivorans LMG13010 bacteria suspended in 20 l of PBS instilled intranasally, and mice were maintained for 5 days before sacrifice by cervical dislocation.…”
Section: Figmentioning
confidence: 99%
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“…Some of these types of studies are under way, such as the development of molecules to inhibit the addition of Ara4N residues to lipid A (78) or the synthesis of L-glycero-D-mannoheptose sugars required for the LPS inner core oligosaccharide (43), as well as the manipulation of siderophores to act as "Trojan horses" for the delivery of antibiotics to bacteria (115). Furthermore a vaccine that prevents B. cenocepacia colonization in CF patients could provide additional benefit, and mucosal vaccines for this purpose are being developed (17,106).…”
Section: Discussionmentioning
confidence: 99%
“…These models have been employed to investigate the virulence of different BCC species as well as of mutants to understand the importance of specific genes in disease. These infection models have also been applied to studies of host response, gene therapy, antimicrobial delivery, and immunization for prevention of BCC lung disease (6,32,51).…”
mentioning
confidence: 99%