Nasal Histamine and Heparin in Chronic Rhinitis

Abstract

Histamine and heparin, both free and cellular, were assayed in the nasal mucosa of 11 atopic and 15 nonatopic patients undergoing turbinectomy for chronic rhinitis. There was no significant difference between the free and cellular histamine levels of the atopic and nonatopic patients. There was also no significant difference between the free heparin levels of atopic and nonatopic patients. Mean cellular heparin was, however, significantly greater in the nonatopic group. This finding, together with the results of mast cell counting, suggests either that in atopic patients heparin stores are already depleted prior to turbinectomy, or that in nonatopic individuals nasal mast cells contain an excess of heparin in nonreleasable stores.

Nasal AMP and histamine challenge within and outside the pollen season in patients with seasonal allergic rhinitis

“…22,23 Also, in patients with perennial rhinitis, no increase in nasal histamine release has been demonstrated, indicating a short-term role for histamine only during acute seasonal exposures to pollen. 24 There was a reduction in domiciliary morning PNIF rates during the season but not in the visit-based measurements, such as PNIF rate or NAR. This is likely a function of the increased variability of snapshot measurements as opposed to using serial measures from a 5-day average of repeated measurements.…”

Study of vitamin C therapy in allergic rhinitis

“…Rhinorrhea and sneezing were more common in atopic patients. 2 Smith stated that four of five patients with allergic rhinitis have predominantly nasal symptoms. 3 Symptoms of patients suffering from allergic rhinitis in the present study were compared with a study on nasal allergy by Craddock (Table 4).…”

Role of plasma ascorbic acid in nasal allergy- a review

“…32 Wilson et al demonstrated that histamine provocation of nasal mucosa produces reflex sneezing and marked vasodilation via both H 1 and H 2 receptors in allergic rhinitis. 33 There is significant basal levels of free histamine which is between 14 to 65 ng/ml in patients with allergic rhinitis whereas in controls it is 10.…”