Nasal Gel Loaded with Amphotericin Nanotransferosomes as Antifungal Treatment for Fungal Sinusitis

Hosny, Khaled M.; Alhakamy, Nabil A.

doi:10.3390/pharmaceutics13010035

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…The VRC also contributed to the elevation of serum creatinine and urea levels. This could be ascribed to renal tubule damage and its negative effect on the glomerular filtration process of urea, leading to the accumulation of such parameters in plasma (Hosny & Alhakamy, 2020 ). Furthermore, VRC apparently caused hyperkalemia in treated animals; such an effect could be due to the ability of VRC itself to cause hypoaldosteronism.…”

Section: Resultsmentioning

confidence: 99%

Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles

et al. 2021

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Fungal infections of the paranasal cavity are among the most widely spread illnesses nowadays. The aim of the current study was to estimate the effectiveness of an in situ gel loaded with voriconazole‒clove oil nano-transferosomes (VRC-CO-NT) in enhancing the activity of voriconazole against Aspergillus flavus , which causes rhinosinusitis. The nephrotoxic side effects of voriconazole may be reduced through the incorporation of the clove oil, which has antioxidant activity that protects tissue. The Box‒Behnken design was applied to formulate the VRC-CO-NT. The particle size, entrapment efficiency, antifungal inhibition zone, and serum creatinine concentration were considered dependent variables, and the soybean lecithin, VRC, and CO concentrations were considered independent ones. The final optimized formulation was loaded into a deacetylated gellan gum base and evaluated for its gelation, rheological properties, drug release profile, permeation capabilities, and in vivo nephrotoxicity. The optimum formulation was determined to be composed of 50 mg/mL lecithin, 18 mg/mL VRC, and 75 mg/mL CO, with a minimum particle size of 102.96 nm, an entrapment efficiency of 71.70%, an inhibition zone of 21.76 mm, and a serum creatinine level of 0.119 mmol/L. The optimized loaded in situ gel released 82.5% VRC after 12 hours and resulted in a 5.4-fold increase in drug permeation. The in vivo results obtained using rabbits resulted in a nonsignificant differentiation among the renal function parameters compared with the negative control group. In conclusion, nasal in situ gel loaded with VRC-CO-NT is considered an efficient novel carrier with enhanced antifungal properties with no signs of nephrotoxicity.

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Section: Resultsmentioning

confidence: 99%

Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles

et al. 2021

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Novel Approaches in Nasal In Situ Gel Drug Delivery

Pagano

Perioli

Ricci

2023

Nasal Drug Delivery

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Anticoccidial activity of essential oils containing eugenol against Eimeria tenella in broiler chickens

Geng,

Peng,

et al. 2024

Animal Diseases

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The development of alternative therapies to treat chicken coccidiosis has become a hot topic because of the widespread use of conventional medicines. This study aimed to investigate the effectiveness of eugenol in treating Eimeria tenella infection in broilers. Broiers, at the age of 14 d, were orally infected with sporulated Eimeria tenella oocysts, and then, eugenol essential oil was added to chicken feed at three different dosages (0.1, 0.2 or 0.4 g/kg). The anticoccidial effects of eugenol essential oil were assessed using the anticoccidial index (ACI). As a result, eugenol exhibited a moderate anticoccidial effect, with an ACI of 167.37 at 0.2 g/kg. After eugenol treatment, the expression of occludin in the epithelial cells of the chicken cecum was significantly greater (P < 0.05) than that in the epithelial cells of the nontreated control (IC) group. The proportion of intestinal Lactobacillus_agilli increased. Eugenol therapy dramatically increased the activity of superoxide dismutase. After high-dose treatment, the expression of the proinflammatory factors IL-1β and IL-6 significantly decreased, while the expression of the cytokines IL-4 and IFN-γ significantly increased. The safety of eugenol essential oil was evaluated at the 1, 3 or 6 recommended doses. Overall, no significant differences were detected in the blood tests or serum biochemistry of the chickens between the treatment groups and the control group. As a result, eugenol essential oil can cure chicken coccidiosis by improving the intestinal microbial structure in the chicken cecum and decreasing the cecum's inflammatory reactions, thus strengthening immune function and eventually demonstrating anticoccidial properties.

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Nasal Gel Loaded with Amphotericin Nanotransferosomes as Antifungal Treatment for Fungal Sinusitis

Cited by 3 publications

References 48 publications

Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles

Formulation, optimization, and nephrotoxicity evaluation of an antifungal in situ nasal gel loaded with voriconazole‒clove oil transferosomal nanoparticles

Novel Approaches in Nasal In Situ Gel Drug Delivery

Anticoccidial activity of essential oils containing eugenol against Eimeria tenella in broiler chickens

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