Nasal eosinophilia: an indicator of eosinophilic inflammation in asthma

Abstract

This study brings further evidence that upper airway diseases are an important component of the asthma syndrome. Furthermore, monitoring of nasal eosinophilia by quantitative cytology may be useful as a surrogate of sputum cytology in as a component of composite measurement for determining airway inflammation.

Early-life mold and tree sensitivity is associated with allergic eosinophilic rhinitis at 4 years of age

“…Allergic eosinophilic rhinitis (AER), the primary outcome of this study, was defined as: 1) a positive response to the ISAAC question, 2) a positive SPT to one of 15 aeroallergens, and 3) greater than 5% nasal eosinophils. 3 These AER cases were compared to children without nasal symptoms and negative SPT to all 15 aeroallergens.…”

“…2 In addition to reflecting inflammation within the upper airway, nasal eosinophilia is associated with sputum eosinophilia in AR patients with concomitant asthma. 3 Nasal eosinophils can be objectively measured as a biomarker allergic airway inflammation 3 Nasal eosinophils correlated with chronic nasal symptoms in a cross-sectional study of Finnish children and adults, however their atopic status was unknown. 4 Currently, it is unknown the percentage of young children with AR that have nasal eosinophilia.…”

Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia

“…(3) In contrast, the relationship between sputum eosinophilia and the presence of pharyngeal eosinophils has not been extensively studied. Eosinophil peroxidase (EPX) is a secondary granule protein uniquely secreted by eosinophils that we have shown is easily detected and quantified using a novel enzyme-linked immunosorbent assay (ELISA).…”

Monitoring asthma status

“…The authors found that clinically guided therapeutics resulted in reduced eosinophil and neutrophil counts, whereas the sputum group showed reduced lymphocyte and eosinophil counts but neutrophils were unaffected [61]. Amorim et al [62] designed a cross-sectional study comparing eosinophil counts in induced sputum to nasal lavage in adult asthma patients. The authors found an association of nasal eosinophils with sputum eosinophil counts but no association of nasal eosinophils with FEV 1 , pre/postbronchodilator FEV 1 , or ACQ scores [62].…”

“…Amorim et al [62] designed a cross-sectional study comparing eosinophil counts in induced sputum to nasal lavage in adult asthma patients. The authors found an association of nasal eosinophils with sputum eosinophil counts but no association of nasal eosinophils with FEV 1 , pre/postbronchodilator FEV 1 , or ACQ scores [62].…”