Nasal DNA methylation profiling of asthma and rhinitis

Qi, Cancan; Jiang, Yale; Yang, Ivana V.; Forno, Erick; Wang, Ting; Vonk, Judith M.; Gehring, Ulrike; Smit, Henriëtte A.; Milanzi, Edith B.; Carpaij, Orestes A; Berg, Marijn; Hesse, Laura; Brouwer, Sharon; Cardwell, Jonathan; Vermeulen, C; Acosta‐Pérez, Edna; Canino, Glorisa; Boutaoui, Nadia; Berge, Maarten van den; Teichmann, Sarah A.; Nawijn, Martijn C.; Chen, Wei; Celedón, Juan C.; Xu, Cheng‐Jian; Koppelman, Gerard H.

doi:10.1016/j.jaci.2019.12.911

Cited by 59 publications

(72 citation statements)

References 46 publications

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“…Other genes relevant to epithelial barrier function ( CDH26 , CDHR3 ) were also found differentially methylated 95,97 . In addition to CDHR3, another genes selectively expressed in ciliated epithelial cells, ZMYND10 91 was found to be differentially methylated, which is consistent with an altered airway epithelial composition in asthma. Only one study to date analysed CpG methylation in bronchial biopsies from asthma patients and healthy controls, but this analysis was focussed on methylation patterns associated with remission of asthma 99 …”

Section: Epigenetic Factors and The Epithelial Barrier In Asthmamentioning

confidence: 99%

Epithelial cell dysfunction, a major driver of asthma development

Heijink

Kuchibhotla

Roffel

et al. 2020

Allergy

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184

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Asthma is a chronic inflammatory airway disease characterized by coughing, wheezing, chest tightness, variable airflow limitation and airway hyper-responsiveness (AHR) 1 to environmental specific (allergens such as house dust mite (HDM), pollen and animal dander) and nonspecific (eg tobacco smoke, air pollution) stimuli. Asthma is a heterogeneous disease with a complex aetiology. Allergen-induced asthma is the most common form, with atopy and allergic sensitization being identified as major risk factors. 2 Other risk factors include increased viral infections during early childhood, exposure to tobacco smoke and air pollution. 3 In

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Section: Epigenetic Factors and The Epithelial Barrier In Asthmamentioning

confidence: 99%

Epithelial cell dysfunction, a major driver of asthma development

Heijink

Kuchibhotla

Roffel

et al. 2020

Allergy

Self Cite

184

145

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“…7 The possible protective effect of pet ownership might be explained by an immunomodulatory effect of exposure to allergens, endotoxins, or bacteria 7 or by affecting DNA methylation. 25 However, the F I G U R E 2 A, Association between demographic risk factors and any atopic disease and recurrent respiratory tract infections. CI, confidence interval; GA, gestational age; mat, maternal; OR, odds ratio; pat, paternal; RRTI, recurrent respiratory tract infections.…”

Section: Child's Comorbiditymentioning

confidence: 99%

Risk factors for atopic diseases and recurrent respiratory tract infections in children

Kansen

Lebbink

Mul

et al. 2020

Pediatric Pulmonology

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Introduction: The simultaneously increased prevalence of atopic diseases and decreased prevalence of infectious diseases might point to a link between the two entities. Past work mainly focused on either atopic diseases or recurrent infections. We aim to investigate whether risk factors for atopic diseases (ie, asthma, allergic rhinitis, atopic dermatitis, and/or food allergy) differ from risk factors for recurrent respiratory tract infections (RRTIs) in children. Methods: Cross-sectional data were used from 5517 children aged 1 to 18 years who participated in an Electronic Portal for children between 2011 and 2019. Univariable/multivariable logistic regression analyses were performed to determine risk factors for any atopic disease and RRTIs. Results: Children aged ≥5 years were more likely to have any atopic disease (adjusted odds ratio [OR]: 1.50-2.77) and less likely to have RRTIs (OR: 0.68-0.84) compared to children aged less than 5 years. Female sex (OR: 0.72; 95% confidence interval [CI]: 0.63-0.81), low birth weight (OR: 0.74; 95% CI: 0.57-0.97) and dog ownership (OR: 0.79; 95% CI: 0.66-0.95) reduced the odds of any atopic disease, but not of RRTIs. Daycare attendance (OR: 1.22; 95% CI: 1.02-1.47) was associated with RRTIs, but not with atopic diseases. A family history of asthma, allergic rhinitis, atopic dermatitis, and RRTIs was significantly associated with the same entity in children, with OR varying from 1.58 (95% CI: 1.35-1.85) in allergic rhinitis to 2.20 (95% CI: 1.85-2.61) in asthma. Conclusion: Risk factors for atopic diseases are distinct from risk factors for RRTIs, suggesting that the changing prevalence of both entities is not related to shared risk factors.

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“…With respect to study design, further studies in longitudinal cohorts are required to develop predictive nasal methylation panels suitable for early prediction of asthma, as well as gene candidate studies to analyze genes found to be significantly related with asthma. Since sensitization to aeroallergens has been found to drive an overlap between nasal methylome correlated with asthma and rhinitis (35), future studies should carefully consider the coexistence of rhinitis when investigating the association of DNA methylation with asthma in nasal epithelium. Furthermore, it would be fascinating to study the influence of aging on DNA methylation on this tissue, which is particularly exposed to environmental factors.…”

Section: Future Perspectivesmentioning

confidence: 99%