Nasal Cartilage Maturation Assessed by Automated Computer-Assisted Image Analysis

Loosen, J. Van; Yiang, J.; Howard, Carole; Zanten, B.A. van; Verwoerd-Verhoef, H.L.; Verwoerd, C. D. A.; Velzen, D. van

doi:10.1159/000058934

Cited by 6 publications

(7 citation statements)

References 5 publications

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“…Two ossification centers in the PPE and the vomer are united below the caudal part of the nasal septal cartilage 11 . According to the cadaver study of Van Loosen et al 12 , the cartilaginous septum develops rapidly in size during the first years of life, with the total area remaining constant after the age of 2 years. In contrast, endochondral ossification of the cartilaginous septum resulting in the formation of the PPE begins after the first 6 months of life and continues until age 36 years 10 , 11 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Development of the Nasal Septum and Measurement of the Harvestable Septal Cartilage in Koreans Using Three-Dimensional Facial Bone Computed Tomography Scanning

et al. 2014

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BackgroundThe septal cartilage is the most useful donor site for autologous cartilage graft material in rhinoplasty. For successful nasal surgery, it is necessary to understand the developmental process of the nasal septum and to predict the amount of harvestable septal cartilage before surgery.MethodsOne hundred twenty-three Korean patients who underwent three-dimensional (3D) facial bone computed tomography (CT) were selected for evaluation of the midsagittal view of the nasal septum. Multiple parameters such as the area of each component of the nasal septum and the amount of harvestable septal cartilage were measured using Digimizer software.ResultsThe area of the total nasal septum showed rapid growth until the teenage years, but thereafter no significant change throughout the lifetime. However, the development of the septal cartilage showed a gradual decline due to ossification changes with aging after puberty in spite of a lack of change in the total septal area. The area of harvestable septal cartilage in young adults was 549.84±151.26 mm2 and decreased thereafter with age.ConclusionsA 3D facial bone CT scan can provide valuable information on the septal cartilage graft before rhinoplasty. Considering the developmental process of the septal cartilage identified in this study, septal surgery should not be performed until puberty due to the risk of nasal growth impairment. Furthermore, in elderly patients who show a decreased cartilage area due to ossification changes, septal cartilage harvesting should be performed carefully due to the risk of saddle nose deformity.

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Section: Discussionmentioning

confidence: 99%

Analysis of the Development of the Nasal Septum and Measurement of the Harvestable Septal Cartilage in Koreans Using Three-Dimensional Facial Bone Computed Tomography Scanning

et al. 2014

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“…In newborns, the septum cartilage, which reaches from the sphenoid to the columella, demonstrates a specific morphologic organization of thicker and thinner parts. 30,31 The transverse diameter may vary from 0.4 to 3.5 mm. The thickest cartilage is found near the junction with the sphenoid rostrum, with a decrease in the more-anterior parts.…”

Section: Nasal Growth In Childrenmentioning

confidence: 99%

Septoplasty in Children

Cingi

Muluk

Ulusoy

et al. 2016

Am J Rhinol�Allergy

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“…Much more limited proliferation was noted up to the age of 35 years in the anterior central part of the NS. 43 , 46 However, it is not clear whether this compensates for cell apoptosis. Studies on minipigs also described a high proliferative capacity of the anterior central cartilage, as well as decreasing cellularity with age.…”

Section: Resultsmentioning

confidence: 99%

“… 14 , 15 Several studies correlated changes to cellularity with episodic growth of the NSC in humans. 8 , 13 , 29 , 43 , 46 NSC growth is rapid during the first 2 years of life and plateaus by early adulthood (20 years). Data for children and adolescents are very limited.…”

Section: Resultsmentioning

confidence: 99%

Properties of the Nasal Cartilage, from Development to Adulthood: A Scoping Review

et al. 2022

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Objective Nasal septum cartilage is a hyaline cartilage that provides structural support to the nasal cavity and midface. Currently, information on its cellular and mechanical properties is widely dispersed and has often been inferred from studies conducted on other cartilage types such as the knee. A detailed understanding of nasal cartilage properties is important for several biological, clinical, and engineering disciplines. The objectives of this scoping review are to (1) consolidate actual existing knowledge on nasal cartilage properties and (2) identify gaps of knowledge and research questions requiring future investigations. Design This scoping review incorporated articles identified using PROSPERO, Cochrane Library (CDSR and Central), WOS BIOSIS, WOS Core Collection, and ProQuest Dissertations and Theses Global databases. Following the screening process, 86 articles were considered. Articles were categorized into three groups: growth, extracellular matrix, and mechanical properties. Results Most articles investigated growth properties followed by extracellular matrix and mechanical properties. NSC cartilage is not uniform. Nasal cartilage growth varies with age and location. Similarly, extracellular matrix composition and mechanical properties are location-specific within the NSC. Moreover, most articles included in the review investigate these properties in isolation and only very few articles demonstrate the interrelationship between multiple cartilage properties. Conclusions This scoping review presents a first comprehensive description of research on NSC properties with a focus on NSC growth, extracellular matrix and mechanical properties. It additionally identifies the needs (1) to understand how these various cartilage properties intersect and (2) for more granular, standardized assessment protocols to describe NSC.

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Nasal Cartilage Maturation Assessed by Automated Computer-Assisted Image Analysis

Cited by 6 publications

References 5 publications

Analysis of the Development of the Nasal Septum and Measurement of the Harvestable Septal Cartilage in Koreans Using Three-Dimensional Facial Bone Computed Tomography Scanning

Analysis of the Development of the Nasal Septum and Measurement of the Harvestable Septal Cartilage in Koreans Using Three-Dimensional Facial Bone Computed Tomography Scanning

Septoplasty in Children

Properties of the Nasal Cartilage, from Development to Adulthood: A Scoping Review

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