Nasal carriage of Methicillin-resistant Staphylococcus aureus among healthy population of Kashmir, India

Fomda, BA; Thokar, Manzoor Ahmad; Khan, Ajaz Kariem; Bhat, JA; Zahoor, Danish; Bashir, Gulnaz; Majid, Abdul; Ray, Pallab

doi:10.4103/0255-0857.124296

Cited by 23 publications

(19 citation statements)

References 13 publications

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“…In a study from Kashmir, India, community prevalence of 27.92% was noted with highest nasal carriage rate of 15.17% in the age group 30–39 years. Methicillin resistance was noted in 1.83% of the isolates . We found a higher MRSA prevalence, possibly due to the contact with health care environment by dialysis patients and uremia.…”

Section: Discussionmentioning

confidence: 63%

Extranasal Staphylococcus aureus colonization predisposes to bloodstream infections in patients on hemodialysis with noncuffed internal jugular vein catheters

Devraj

Pinnamaneni

Biswal

et al. 2016

Hemodialysis International

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Section: Discussionmentioning

confidence: 63%

Extranasal Staphylococcus aureus colonization predisposes to bloodstream infections in patients on hemodialysis with noncuffed internal jugular vein catheters

Devraj

Pinnamaneni

Biswal

et al. 2016

Hemodialysis International

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“…An empiric broad spectrum antibiotic therapy with meropenem and azithromycin was administered instead of amoxicillin/clavulanic acid and clarithromycin previously given in the ED. On day 2, reconsidering the patient´s recent travel history and potential exposure to CA-MRSA [1], linezolid was added. On day 3, azithromycin was stopped and teicoplanin was started due to positive blood cultures for methicillin-resistant, Panton-Valentine leucocidin producing Staphylococcus aureus (PVL + MRSA).…”

Section: Casementioning

confidence: 99%

Two cases of serious rhabdomyolysis during linezolid treatment

et al. 2017

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Linezolid is an oxazolidinone antibiotic with activity against gram-positive organisms, particularly methicillin-resistant Staphylococcus aureus (MRSA). To the best of our knowledge, there are only two case reports on rhabdomyolysis in patients treated with linezolid. Here, we describe two cases of serious rhabdomyolysis: one in a patient with septic community-acquired (CA)-MRSA pneumonia and a second case in a patient with suspected catheter-related blood stream infection.

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“…MRSA strains are a versatile and most significant nosocomial pathogen, often causing postsurgical wound infections almost exclusively of hospital origin described in 1961 [6]. MRSA infections account for 20-80% of all nosocomial S. aureus infectionsin many centers across the world [7,8] that lead to increased mortality, morbidity hospital stay, and costs [9,10]. WHO (2018) have reported that 64% of MRSA infected patients are more likely to die than non MRSA infected patients [11].…”

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confidence: 99%

Antibiotic resistance pattern of Staphylococcus aureus with reference to MRSA isolates from pediatric patients

Gurung

Maharjan

2019

Preprint

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Background: Staphylococcus aureus is one of the important superbugs distributed throughout the world. It causes minor skin infections to severe complications including nosocomial infections in both hospitals and community settings. These strains have multi-drug resistant property. Hence, they are difficult to manage which increase health-related costs and simultaneously intensifying the need for new antibiotics. The extent of Methicillin-Resistant Staphylococcus aureus (MRSA) in children is largely unknown. The study determines the current status of S. aureus and MRSA causing various infections in pediatric patients visiting International Friendship Children’s Hospital (IFCH). Methods: A cross-sectional study was conducted among patients visiting a hospital. Various clinical specimens were aseptically collected and processed according to standard microbiological procedures. Isolation and identification of S. aureus were done by microscopy, mannitol fermentation, and coagulase positivity. All identified S. aureus isolates subjected to in-vitro antibiogram by Kirby-Bauer disc diffusion technique adopting Clinical and Laboratory Standards Institute (CLSI) guideline. Isolates resistant to cefoxitin were considered to be MRSA. Whereas, isolates produced D-shaped inhibition zone around clindamycin when kept near erythromycin were considered to be Inducible Clindamycin Resistant (ICR). Results: 672 various types of clinical samples were processed from the microbiology laboratory from June and November 2015. Out of 300 culture positive samples, 52 (17.3%) were S. aureus isolates, among them 39 (75.0%) were found to be MRSA. The D-test showed that Macrolide-Lincosamide-Streptogramin-B (MLSB) phenotype was 15.4%. Conclusion: The study shows the MRSA occurrence is prevalent in pediatric patients and newer classes’ drugs are found more effective than β-lactam drugs to treat S. aureus infection. However, restriction on the indiscriminate use of such drugs may be an effective strategy to control the drug resistance. Keywords: Methicillin-Resistant Staphylococcus aureus (MRSA), Macrolide-Lincosamide-Streptogramin B (MLSB) phenotype, Inducible Clindamycin Resistant (ICR) test or D-zone test, Antibiotic resistance, Nepal

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Nasal carriage of Methicillin-resistant Staphylococcus aureus among healthy population of Kashmir, India

Abstract: High prevalence of MRSA is a cause of concern and strategies to interrupt transmission should be implemented.

Cited by 23 publications

References 13 publications

Extranasal Staphylococcus aureus colonization predisposes to bloodstream infections in patients on hemodialysis with noncuffed internal jugular vein catheters

Extranasal Staphylococcus aureus colonization predisposes to bloodstream infections in patients on hemodialysis with noncuffed internal jugular vein catheters

Two cases of serious rhabdomyolysis during linezolid treatment

Antibiotic resistance pattern of Staphylococcus aureus with reference to MRSA isolates from pediatric patients

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