Nasal capillariosis due to Eucoleus boehmi in two naturally infected dogs

Cervone, Mario; Messina, N.; Perrucci, Stefania

doi:10.1016/j.anicom.2017.04.001

Cited by 3 publications

(7 citation statements)

References 15 publications

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“…The results of the present study indicate that the combination product containing MO and afoxolaner (NEXGARD SPECTRA ® ) had a beneficial effect for treating pulmonary and nasal capillarioses in infected dogs with two consecutive monthly treatments. This study confirms previous reports on the efficacy of MO against Capillaria infections in dogs under field conditions [ 3 , 18 , 20 , 23 , 24 ]. A > 99% efficacy of NEXGARD SPECTRA ® in reduction of egg shedding in dogs has been previously published, although the eggs were not identified to species [ 18 ].…”

Section: Discussionsupporting

confidence: 92%

“…A recent study that investigated the combined monthly use of NEXGARD SPECTRA ® and fipronil/permethrin (FRONTLINE TRI-ACT ® , Boehringer Ingelheim Vetmedica GmbH) against endo- and ectoparasites of dogs indicated 100% efficacy against C. aerophila in 8 dogs 14 days after treatment [ 20 ]. The therapeutic efficacy of MO against C. boehmi was also reported in single clinical cases [ 23 , 24 ]. Off-label therapeutic options, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…Afoxolaner is efficacious against major fleas, ticks and mites in dogs, while MO provides efficacy against intestinal and extra-intestinal nematodes. MO has been reported to be efficacious against canine capillarioses [ 18 , 20 , 23 , 24 ]. The present study aimed to assess the efficacy of MO contained in NEXGARD SPECTRA ® for the treatment of naturally acquired C. aerophila and/or C. boehmi infections in dogs under field conditions.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of milbemycin oxime/afoxolaner chewable tablets (NEXGARD SPECTRA®) against Capillaria aerophila and Capillaria boehmi in naturally infected dogs

et al. 2021

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Background Capillaria aerophila and Capillaria boehmi parasitize the respiratory system of wild and domestic carnivores. Capillaria aerophila inhabits the trachea and bronchi of dogs and cats, while C. boehmi affects the nasal cavities and sinuses of dogs. In dogs the infection may be subclinical or characterized by varying respiratory distress. Methods The present study evaluated the efficacy of an oral formulation containing milbemycin oxime and afoxolaner (NEXGARD SPECTRA®) in dogs naturally infected with C. aerophila and/or C. boehmi from three enzootic areas of Italy. Dogs were enrolled pending fecal examination and molecular confirmation of respiratory capillarioses. Dogs were allocated in two groups: Group 1 (G1, 25 dogs), treated with a negative control product with no anthelmintic activity (afoxolaner, NEXGARD®), and Group 2 (G2, 26 dogs), treated with NEXGARD SPECTRA®. At the day of treatment administration (Day 0), all dogs were clinically examined. Dogs were again subjected to clinical and fecal examinations at Days 28 (± 4) and 56 (± 2). The primary criterion for treatment efficacy was the reduction of fecal Capillaria egg counts in G2 compared with G1. The regression of/recovery from baseline clinical signs was considered as a further efficacy criterion. Results Percentage reduction of fecal Capillaria egg counts in the NEXGARD SPECTRA® group compared to the control group was > 97% on Day 28 and 100% on Day 56, respectively (p < 0.05 for both time points). Twelve of the 13 dogs in the NEXGARD SPECTRA® group with respiratory signs prior to treatment were free of clinical signs at the end of the study. Conversely, the six control group dogs with respiratory signs prior to treatment remained symptomatic. Conclusions Results of the present study showed that NEXGARD SPECTRA® was safe and highly efficacious in the reduction of C. aerophila and C. boehmi eggs after one treatment with a complete reduction of the egg output after the second administration associated with a recovery from respiratory signs.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of milbemycin oxime/afoxolaner chewable tablets (NEXGARD SPECTRA®) against Capillaria aerophila and Capillaria boehmi in naturally infected dogs

et al. 2021

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“…2). Therefore, the morphological characters of eggs studied in the present work were similar to those described for eggs of E. boehmi from Europe (De Liberato et al 2009;Traversa et al 2010;Magi et al 2012;Al-Sabi and Kapel 2013;Hodžić et al 2016;Cervone et al 2017). Results of molecular analysis showed an identical 344-bp fragment of cox1 gene to eggs isolated from both dog fecal samples.…”

Section: Resultssupporting

confidence: 85%

“…Eucoleus boehmi (Supperer 1953) has been reported in dogs from Italy, Portugal, and USA and in red foxes from Italy, Denmark, and Austria (De Liberato et al 2009;Magi et al 2012;Al-Sabi and Kapel 2013;Clark et al 2013;Veronesi et al 2014;Alho et al 2016;Hodžić et al 2016;Cervone et al 2017). This parasite is found in the nasal turbinates, frontal and paranasal sinuses of canids.…”

Section: Introductionmentioning

confidence: 99%

First morphological and molecular analysis of Eucoleus boehmi like eggs in dogs from Argentina

et al. 2018

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The canid parasites Eucoleus aerophilus (syn. Capillaria aerophila) and Eucoleus boehmi (syn. Capillaria boehmi) parasitize the lower and the upper respiratory tract, respectively. Reports and descriptions of these nematodes are scarce in Argentina, possibly due to misdiagnosis of morphologically similar trichuroids eggs, and the lack of knowledge about the species of Eucoleus in this geographical area. Scanning electron microscopy is a useful tool for identification of E. boehmi eggs based on the characteristics of the shell structure which differentiate between species. Molecular analysis complements morphological identification. Until now, there are no studies based on the analysis of E. boehmi eggs in Argentina. The aim of the present work was to study by morphological, morphometric, and molecular analysis, eggs attributable to E. boehmi isolated from dogs naturally infected in Mar del Plata city, Argentina. Eggs isolated from two dog fecal samples were analyzed by light and scanning electron microscopy. A fragment of mitochondrial DNA (mtDNA) of the cytochrome c oxidase subunit I gene (cox1) from eggs was sequenced, and phylogenetic analysis was performed in this study. According to morphological results based on the wall surface ultrastructure, the eggs studied were assigned to E. boehmi. Molecular analysis supported the morphological identification. The divergence of 9-12% with the European isolated could suggest a new geographical genetic variation of E. boehmi, but also question the possible existence of cryptic species. This is the first characterization of E. boehmi eggs in dogs from Argentina.

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Filaroidosis infection in an immunocompetent adult dog from France

Cervone¹,

Giannelli

Rosenberg³

et al. 2018

Helminthologia

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SummaryA dog from Paris (France) was referred with a 2-week history of dry cough, intermittent acute onset of dyspnoea, and acute abdominal pain. A generalised bronchoalveolar infi ltrate with a patchy distribution was observed at chest x-rays and computed tomography (CT) scans. Negative results were obtained through several faecal examinations for cardiorespiratory nematodes by using the Baermann technique and at two blood analysis with a commercially available test for the detection of A. vasorum antigen (the fi rst one at the fi rst visit and second one at the control visit, one month later). PCR methods for the identifi cation of A. vasorum and C. vulpis were also accomplished. At the control visit, nematode L1s were found during direct microscopic examination of bronchoalveolar lavage fl uid (BALF). Thus, a different antigen-based assay for the detection of A. vasorum was performed with a positive result. Moreover, based on morphology, isolated larvae were identifi ed as Filaroides hirthi. The dog was treated with fenbendazole (50 mg/kg per os once daily) for two consecutive weeks. After fi ve months, the dog was referred again for the intermittent acute onset of dyspnoea and was found to be still positive for F. hirthi larvae at BALF examination. A 15-day treatment regimen with fenbendazole in combination with three subcutaneous injections of ivermectin (0.4 mg/kg, once every two weeks), was then performed. No larvae were detected at two BALF microscopical examinations performed one month apart. Results from this case report underline the importance of including F. hirthi infections in the differential diagnosis of dog bronchopneumonia.

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Nasal capillariosis due to Eucoleus boehmi in two naturally infected dogs

Cited by 3 publications

References 15 publications

Efficacy of milbemycin oxime/afoxolaner chewable tablets (NEXGARD SPECTRA®) against Capillaria aerophila and Capillaria boehmi in naturally infected dogs

Efficacy of milbemycin oxime/afoxolaner chewable tablets (NEXGARD SPECTRA®) against Capillaria aerophila and Capillaria boehmi in naturally infected dogs

First morphological and molecular analysis of Eucoleus boehmi like eggs in dogs from Argentina

Filaroidosis infection in an immunocompetent adult dog from France

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