Nasal calcitonin

Silverman, Stuart L.

doi:10.1007/bf02738965

Cited by 11 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major side effects are transient nausea and facial flushing. Nasal calcitonin causes less nausea, but 11% of patients develop rhinitis 76 . When administered by either route, calcitonin leads to a prompt fall in urine collagen cross‐link excretion, followed by a fall in serum alkaline phosphatase after several weeks.…”

Section: Assessment Of Disease Activity In Paget's Diseasementioning

confidence: 99%

See 1 more Smart Citation

Paget's Disease of Bone (Osteitis Deformans)

Ankrom

Shapiro

1998

J American Geriatrics Society

View full text Add to dashboard Cite

Paget's disease of bone is important in geriatric populations because it is the second most common bone disorder after osteoporosis. In older people, it may be responsible for chronic back pain and joint pain, skeletal deformities, hearing loss, and cranial nerve compression. Paget's disease can reduce both function and mobility in the older people. In addition to newer tests for assessing the activity of Paget's disease, effective therapy is available in the form of salmon calcitonin for nasal administration and new third generation bisphosphonates. Frequently, treatment can reverse the course of the disease. For these reasons, it is feasible for the physician to adopt an aggressive approach to diagnosis and treatment. The objective should be to relieve pain, improve mobility, and forestall debilitating complications. This review will focus on the manifestations and clinical management of Paget's disease. Two cases are presented that illustrate common management problems in older patients.

show abstract

Section: Assessment Of Disease Activity In Paget's Diseasementioning

confidence: 99%

“…Gallium nitrate: Gallium nitrate, a potent antiresorptive drug, is currently an experimental therapy for Paget's disease of the bone 76–78 . In a multicenter trial, gallium nitrate was administered at doses of 0.05, 0.25, and 0.5 mg/kg/day by subcutaneous injection in two 14‐day cycles.…”

Section: Assessment Of Disease Activity In Paget's Diseasementioning

confidence: 99%

Paget's Disease of Bone (Osteitis Deformans)

Ankrom

Shapiro

1998

J American Geriatrics Society

View full text Add to dashboard Cite

show abstract

“…It is known that the nervous system varies in its susceptibility to toxicant-induced damage with age (e.g., [3][4][5][6][7][8][9][10][11][12]). Given the potential for olfactory mucosal metabolism of compounds, especially the multitude of drugs under development for intranasal administration (e.g., [13][14][15][16][17][18]), it is important to know the metabolic enzymes present in the olfactory mucosa, as well as how the expression and activity of these enzymes change with age. In addition, N-acetyltransferase activities in the olfactory mucosa are described; these enzymes are likely involved in the metabolism of multiple nasal carcinogens, encountered as either environmental contaminants or as metabolites of therapeutically administered drugs.…”

Section: Introductionmentioning

confidence: 99%

Update on olfactory mucosal metabolic enzymes: Age‐related changes and N‐acetyltransferase activities

Genter

2004

J Biochem & Molecular Tox

View full text Add to dashboard Cite

We have expanded previous observations on olfactory metabolic enzymes by examining the content of various metabolic enzymes in the olfactory mucosa of the male Long-Evans rat at different ages. Age-related changes in metabolic enzyme content may be related to changes in susceptibility to toxicants with age and may also contribute to altered odorant perception in the elderly. While some enzymes did not vary over the age range examined, decreases in the microsomal content of other enzymes were observed. While mRNA for acetyltransferase enzymes has previously been described in olfactory mucosa, the markedly higher activity of olfactory acetyltransferases compared to liver had not previously been described. Acetyltransferases are important in the metabolism of drugs and toxicants that are aromatic amine derivatives and may contribute to the bioactivation of rodent olfactory mucosal carcinogens such as 2,6-dimethylaniline and alachlor. These studies show that the olfactory mucosa varies in its metabolic capacity with age, and characterize another class of metabolic enzymes in the olfactory mucosa, both of which may impact significantly on responses to toxicants and therapeutic agents in the nasal cavity.

show abstract

“…Clinical interventions for bone health in women with physical disabilities require tailoring to individual health needs. Calcitonin nasal spray is effective on a short‐term basis, particularly for women with vertebral compression fractures (Silverman, 1997). Each of the bisphosphonates has specific uses for women with physical disabilities.…”

mentioning

confidence: 99%