Nasal and systemic inflammatory profile after short term smoking cessation

Abstract

The short term smoking abstinence decreased systemic inflammation and improved nasal mucociliary clearance, despite not having changed the nasal inflammation.

Nutritional status and muscle dysfunction in chronic respiratory diseases: stable phase versus acute exacerbations

“…On the one hand, it will eliminate the anorectic effect of tobacco, improving diet quality (223). On the other, systemic inflammation and oxidative stress, as well as protein synthesis/breakdown imbalance will be reduced, with improvements in body weight, as well as in muscle mass and function (224)(225)(226)(227).…”

Changes in systemic inflammatory and nasal mucociliary response following smoking cessation

“…Mendal et al [46] reported that serum IL-6 levels were increased in smokers. However, Rodrigues et al [21] found that quitters and active smokers had similar IL-6, IL-8, and IL-10 levels, and they mentioned that 30 days was a relatively short period for quitting. Similarly, Van Keulen et al [47] found in their study in Brazil that serum levels of TNF-α, IL-1, IL-6, IL-8, IL-10 and IL-12 were similar at 4 th month of quitting when compared to basal levels.…”

“…In the same study, IL-1a and TNF-α levels were found to be decreased to basal levels at 8 weeks after the elimination of the smoke. Rodrigues et al [21] conducted a study in Brazil with 25 patients, and found that TNF-α levels decreased significantly in patients who quit smoking for 30 days when compared to active smokers. In our study, we found that serum TNF-αlevels were decreased significantly at 2 months after quitting when compared with the basal levels.…”

“…Rodrigues F.M.M. et al [21]could not determine a change in serum IL-10 levels following 1 month of smoking cessation in their study that included 25 patients in Brazil.…”

Current research on cigarette toxicity: critical appraisal in view of clinical laboratory

“…42,43 Reduction of inflammatory markers in blood after cessation of smoking for a period of one month shown by a recent study also suggest the role of smoking on systemic inflammation. 44 Increased Nitric oxide bioavailability is reduced and endothelium dependent vasodilation is decreased as a results of cigarette smoking. 45,46 Activity and expression of the enzyme endothelial nitric oxide synthase is altered by cigarette smoke.…”