Nasal Allergen Sensitivity and Mucosal IgE Antibodies

Ōhashi, Y.; Nakai, Yousuke; Kihara, Shoko; Ikeoka, Hiroshi; Nakata, Junko; Koshimo, Hiroyuki

doi:10.1159/000275930

Cited by 8 publications

(5 citation statements)

References 7 publications

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“…Tissue sIgE concentration also correlated with serum sIgE (r ¼ .64, P < .01) and SPT wheal diameter (r ¼ .37, P < .01). Two previous studies by Ohashi et al 7 found that tissue sIgE can be quantified and were comparable to systemic sensitization. 4,7 Another small study also confirmed good correlation between tissue sIgE and serum sIgE among 11 patients with AR.…”

Section: Discussionmentioning

confidence: 83%

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Turbinate-Specific IgE in Normal and Rhinitic Patients

Hamizan

Rimmer

Alvarado

et al. 2019

Am J Rhinol�Allergy

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Background Specific immunoglobulin E (sIgE) within the nasal airway is likely to be the most ideal marker of allergic status, but little is known of the normative values in asymptomatic patients and those with rhinitis. Objective The aim of this study was to assess the diagnostic characteristics of inferior turbinate tissue biopsy sIgE in asymptomatic and rhinitic patients. Methods A diagnostic cross-sectional study was undertaken, involving patients who underwent inferior turbinate surgery with or without other surgical interventions. Inferior turbinate tissue biopsy was performed during surgery and was assessed for allergen sIgE (dust mite, grass [temperate or subtropical], and animal epithelium) using an automated immunoassay. Tissue sIgE was assessed among asymptomatic patients and those with nasal symptoms. Data were presented as median (interquartile range). A receiver operating curve was used to predict the diagnostic utility of turbinate tissue sIgE in determining allergic rhinitis. Results A total of 160 patients (41.89 ± 14.65 years, 36.9% females) were included. The median tissue sIgE concentration among the asymptomatic nonatopic group of patients was 0.09 (0.08–0.10) kUA/L and tissue sIgE > 0.10 kUA/L was determined as a positive threshold. Inferior turbinate tissue sIgE was shown to be a predictive test for allergic rhinitis (area under curve: 0.87, 95% confidence interval: 0.84–0.90) with 90% sensitivity and 89% negative predictive value. Conclusion Inferior turbinate tissue biopsy sIgE is a sensitive tool to predict allergic rhinitis. The threshold value of 0.1 kUA/L corresponded well with the asymptomatic nonatopic group of patients. This method detects sIgE in the nasal mucosa and may be a useful test for allergic rhinitis in future research.

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Section: Discussionmentioning

confidence: 83%

“…7 found that tissue sIgE can be quantified and were comparable to systemic sensitization. 4,7 Another small study also confirmed good correlation between tissue sIgE and serum sIgE among 11 patients with AR. 8 Therefore, tissue sIgE concentration has good agreement with systemic allergy among those with nasal symptoms (AR).…”

Section: Discussionmentioning

confidence: 89%

Turbinate-Specific IgE in Normal and Rhinitic Patients

Hamizan

Rimmer

Alvarado

et al. 2019

Am J Rhinol�Allergy

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“…Some reports have shown that the allegen-specific IgE in nasal secretions or in nasal mucosa is much more related to clinical symptoms than serum antibody levels [1 6]. Furthermore, in one study the results of the RAST on nasal secretions were in good agreement with bronchial provocation testing [7], The increase of timothy-specific IgE during the pollination season was significantly more pronounced in nasal secretions than in serum [8], The local synthesisof IgE antibody has also been suggested by (1) the finding of IgE-forming cells [9,10] and specific IgE antibody [I] in the mucosa of the respiratory tract, and Z. Peng et.a\.…”

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confidence: 94%

“…In previous studies specimens had to be concentrated prior to assay because of low antibody concentrations in nasal washes. Some have tried to collect concentrated nasal secretions by (1) placing a strip of filter paper in the nose [2,4,25], (2) irritating the nasal passages with 18"/,, saline to stimulate nasal secretions [5,7], (3) spray washing [26] or (4) suction prior to tissue removal [14]. None of these techniques have allowed routine measurement of IgE antibodies in unconcentrated nasal fluids or washes.…”

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confidence: 99%

Ragweed IgE and IgG4 antibody in nasal secretions during immunotherapy

Peng

Lee

Naclerio

et al. 1990

Clin Experimental Allergy

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We have developed sensitive amplified immunoassays for measurement of IgE and IgG4 ragweed (RW) antibodies in unconcentrated nasal washes. IgE to Amb a I (formerly antigen E) can be assayed to less than 0.1 ng/ml using IgE capture by anti-IgE on microtitre plates and an alkaline phosphatase-conjugated Amb a I with an amplification substrate technique. IgG4 to whole RW extract was assayed to less than 0.01 ng/ml by amplification ELISA using monoclonal anti-IgG4. Nasal washes (NW) (10 ml) and serum were obtained in December from 22 RW-sensitive patients before and after 1 and 2 yr of RW immunotherapy (IT), and assayed for Amb a I IgE or RW IgE and RW IgG4 antibodies Amb a I IgE could be measured in the NW of 15/22 pre IT, 19/22 at 1 yr IT, but only 3/10 at 2 yr IT (compared with pre-IT, P less than 0.05). Mean Amb a I IgE in NW was 0.66, 0.36 and 0.21 ng/ml at pre, 1 yr and 2 yr IT (P-values greater than 0.05). Mean serum RW IgE, was 76, 55 and 27 ng/ml at pre, 1 yr and 2 yr IT (P-values greater than 0.05). Amb a I IgE in nasal washes was correlated with RW IgE in serum (r = 0.56, P less than 0.001, n = 44). RW IgG4 was detectable in NW of 15/22 pre-IT, 18/22 at 1 yr IT and 9/10 at 2 yr IT (P-values greater than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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“…If IgE production really took place in the nasal mucosa, a positive nasal provo cation test and negative skin and in vitro serum tests in one and the same patient [19,25] could be explained. Studies of the IgEproducing organ could probably show im portant differences in quantity or function of various involved cell populations, e.g.…”

Section: Introductionmentioning

confidence: 99%

Localization of IgE Synthesis in Immediate-Type Allergy of the Upper Respiratory Tract (With 3 color plates)

Ganzer

Bachert²

1988

ORL

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The localization of allergen-specific IgE synthesis in allergic diseases of the upper respiratory tract is so far unknown. It has been suggested that the IgE production takes place in the nasal mucosa itself. The present immunohistochemical studies with anti-IgE and monoclonal markers for B lymphocytes, plasma cells, antigens of the major histocompatibility complex, T helper and T suppressor cells indicate that there are no IgE-producing plasma cells in the nasal mucosa of patients with seasonal allergic rhinitis. The IgE-associated cells have been defined as two different types of mast cells. Furthermore we found IgE-associated lymphoid follicles in palatine as well as in nasopharyngeal tonsils and in cervical lymph nodes from allergic patients. IgE-specific activated B lymphocytes and plasma cells were identified in direct contact with migratory mast cells in these lymphoid tissues. We therefore suggest that IgE synthesis takes place in the lymphoid tissues of Waldeyer’s ring and in downstream cervical lymph nodes and that migratory mast cells transport specific IgE back to the nasal mucosa to mediate the allergic reaction.

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Nasal Allergen Sensitivity and Mucosal IgE Antibodies

Cited by 8 publications

References 7 publications

Turbinate-Specific IgE in Normal and Rhinitic Patients

Turbinate-Specific IgE in Normal and Rhinitic Patients

Ragweed IgE and IgG4 antibody in nasal secretions during immunotherapy

Localization of IgE Synthesis in Immediate-Type Allergy of the Upper Respiratory Tract (With 3 color plates)

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