Nasal airflow resistance measured by rhinomanometry in a healthy population of China

Ren, Lei; Zhang, Luo; Duan, Su; Zhang, Wei; Zhang, Yuan

doi:10.1002/alr.22177

Cited by 14 publications

(18 citation statements)

References 10 publications

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“…However, the sex difference in the current study can be reasonably explained. In our previous study of nasal resistance, the total nasal resistance is significantly higher in females than in males 37. In the current study, the nNO level is positively correlated with total nasal resistance, which could explain why females have higher nNO levels than males.…”

Section: Discussionsupporting

confidence: 51%

Nasal Nitric Oxide Is Correlated With Nasal Patency and Nasal Symptoms

Ren

Zhang

et al. 2019

Allergy Asthma Immunol Res

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Purpose Nitric oxide (NO) is an important endogenous mediator in both upper and lower respiratory systems. The purpose of the present study was to extract nasal NO (nNO) normal range of Chinese adults and the internal influencing factors. The differences in nNO levels between rhinitis and asymptomatic atopic subjects, and the diagnostic value of nNO in allergic rhinitis (AR) were further investigated. Methods One thousand adults were recruited from the general public. Participants were divided into different subgroups according to the questionnaires and skin prick tests. In all of these subjects, nNO, fractional exhaled NO (FeNO) and nasal airflow resistance were measured. The normal ranges of nNO and FeNO, the differences between subgroups, and the correlations between NO (nNO and FeNO) and other internal factors were analyzed. Results Both nNO and FeNO levels were significantly higher in AR patients than in healthy and asymptomatic atopic subjects. The nNO levels were significantly lower in asymptomatic atopic subjects than in normal adults. FeNO levels were significantly higher in non-AR patients than in the healthy and asymptomatic atopic adults. The cutoff value of nNO for the diagnosis of AR was 117.5 ppb (sensitivity, 50.9%; specificity, 63.9%). The nNO levels were correlated with FeNO levels, total nasal resistance measured at 75Pa, nasal volume within 0–7 cm from the anterior nares (V 0–7cm ) and nasal symptom visual analogue scale (VAS) scores, while the FeNO levels were correlated with age, height, weight, body surface area, nasal volume of V 0–7cm and the nasal symptom VAS score. Conclusions The nNO level can be significantly different between healthy and AR patients and may be significantly correlated with nasal symptoms and nasal patency of rhinitis patients. However, the clinical value of nNO is still in the exploration stage.

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Section: Discussionsupporting

confidence: 51%

Nasal Nitric Oxide Is Correlated With Nasal Patency and Nasal Symptoms

Ren

Zhang

et al. 2019

Allergy Asthma Immunol Res

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“…For the T&T test, a score of 1 was defined as euosmia, 2 = mild hyposmia, 3 = moderate hyposmia, 4 = severe hyposmia and 5 = anosmia. Nasal resistance was measured at 75 Pa and 150 Pa, respectively, by HRR2 four-phase rhinomanometry (Rhino Lab GmbH, Rendsburg, Germany), as described previously [18]. The left (RL) and right (RR) lateral nasal resistance values were calculated according to Ohm’s law; and the total nasal resistance was calculated using the formula (RL × RR)/(RL + RR), and the unilateral nasal resistance calculated usung the formula (RL + RR)/2.…”

Section: Methodsmentioning

confidence: 99%

Association between methylation in nasal epithelial TSLP gene and chronic rhinosinusitis with nasal polyps

Jiao

Gao

et al. 2019

Allergy Asthma Clin Immunol

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BackgroundThis study was performed to determine whether there was any association between abnormal DNA methylation of a thymic stromal lymphopoietin (TSLP) locus and pathogenesis of chronic rhinosinusitis (CRS).MethodsA total of 48 CRS patients with nasal polyps (CRSwNP), 28 CRS patients without nasal polyps (CRSsNP) and 21 control subjects were enrolled into the study; and evaluated for serum total IgE level, olfactory score and nasal resistance. Samples were obtained from nasal polyps of CRSwNP patients, ethmoid mucosae of CRSsNP patients and inferior turbinate (IT) mucosa of control subjects during surgery, and used to isolate purified primary human nasal epithelial cells (HNECs). Genomic DNA was extracted from purified primary HNECs of each subject and DNA methylation ratios for a selected region of the TSLP gene were screened the using MassARRAY EpiTYPER.ResultsA total of 17 CpG units were analyzed; of which two CpG units (CpG3 and 22:23:24) had increased methylation ratios in the CRSwNP patients compared to the CRSsNP and control subjects after correction for false discovery rate (FDR) (Q < 0.1). The methylation ratios at both CpG3 and CpG22:23:24 units were positively correlated with olfactory score (r = 0.41, P = 0.0001; r = 0.25, P = 0.021) and unilateral nasal resistance at 75 Pa (r = 0.24, P = 0.04; r = 0.24, P = 0.036) and 150 Pa (r = 0.34, P = 0.004; r = 0.25, P = 0.031). Total nasal resistance at 75 Pa/150 Pa or serum total IgE levels were not correlated with the methylation ratios at either CpG unit.ConclusionsIncreased DNA methylation at the TSLP locus is likely to be associated with CRSwNP pathogenesis; however these findings need to be confirmed in larger multicentre group studies.

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“…Rhinomanometry can be carried out in children; NAR decreases with age and is lower for girls than boys (305) . Reference values are available for children and adults (Table 5) (260,306,307) . Normal values for 4PR have also been reported (308,309) .…”

Section: Rhinomanometry (Rm)mentioning

confidence: 99%

European position paper on diagnostic tools in rhinology

Rimmer

Hellings

Lund

et al. 2019

Rhin

114

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is the official Journal of the European and International Rhinologic Societies and appears quarterly in March, June, September and December. Cited in Pubmed, Current Contents, Index Medicus, Exerpta Medica and Embase Founded in 1963 by H.A.E. van Dishoeck, Rhinology is a worldwide non-profit making journal. The journal publishes original papers on basic research as well as clinical studies in the major field of rhinology, including physiology, diagnostics, pathology, immunology, medical therapy and surgery of both the nose and paranasal sinuses. Review articles and short communications are also pulished. All papers are peer-reviewed. Letters-to-the-editor provide a forum for comments on published papers, and are not subject to editorial revision except for correction of English language. In-depth studies that are too long to be included into a regular issue can be published as a supplement. Supple ments are not subject to peer-review.

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Nasal airflow resistance measured by rhinomanometry in a healthy population of China

Abstract: These reference values maybe useful for the Chinese clinicians in evaluating the nasal function and in choosing and assessing efficacy of therapy for nasal congestion in Chinese patients.

Cited by 14 publications

References 10 publications

Nasal Nitric Oxide Is Correlated With Nasal Patency and Nasal Symptoms

Nasal Nitric Oxide Is Correlated With Nasal Patency and Nasal Symptoms

Association between methylation in nasal epithelial TSLP gene and chronic rhinosinusitis with nasal polyps

European position paper on diagnostic tools in rhinology

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