Nasal administration of albuterol: an alternative route of delivery

Abstract

The use of metered-dose inhalers for the delivery of albuterol, a beta2-selective adrenergic agonist, is associated with drawbacks, especially in children and the elderly. This investigation was designed to assess the effectiveness of albuterol delivered intranasally and to compare this delivery route with intratracheal and intravenous delivery. Three parameters of pulmonary function (peak maximal expiratory flow, maximal expiratory flow at 50% vital capacity, and total lung capacity) in anaesthetized, artificially ventilated guinea pigs were used to determine the degree of protection produced by albuterol against bronchoconstrictor responses provoked by acetylcholine. The heart rate was also measured. Although intranasal albuterol induced a slower protective action during the very initial phase of absorption, the drug was shown to be equally effective when administered either intranasally or intratracheally. In contrast, despite a significant effect initially in the case of intravenous albuterol, its ability to influence pulmonary function faded rather rapidly. No statistically significant differences in heart rate could be detected among the different treatment groups. In conclusion, intranasal albuterol may offer an alternative to metered-dose inhalers for the treatment of acute bronchospasm and for prevention of exercise-induced asthma, especially for children and the elderly.

Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness

“…4a ). CCKAR antagonists were administered via intranasal delivery, which may avoid undesirable side effects and limit the gastrointestinal-hepatic first-pass metabolism that can contribute to loss of administered drugs 52 , 53 . Consistent with the known effects of HFD on airway function 51 , in the absence of CCKAR antagonists, we observed an increased AHR in HFD-fed mice as compared to the regular chow mice (Fig.…”

Effect of Intranasal Salbutamol on the Nose Obstruction Seen in Pediatric Patients with Allergic Rhinitis

“…Hussain ve ark. intranazal albuterolün özellikle çocuklar ve yaşlılarda akut bronkospazmın tedavisinde ve egzersizle başlayan astımın önlenmesinde inhalerlere alternatif sunduğunu göstermişlerdir (8). İntranazal albuterol absorpsiyonun çok erken fazında yavaş koruyucu etki başlatır fakat intranazal ve intratrakeal olarak eşit etkilidir (9).…”

“…Akustik rinometrede çapraz kesit alanı (ÇKA) 1 nazal valve, ÇKA2 inferior veya orta konkanın anterior başına ve ÇKA3 orta konkanın orta-arka kısmına karşılık gelir (3). (8). İntranazal albuterol absorpsiyonun çok erken fazında yavaş koruyucu etki başlatır fakat intranazal ve intratrakeal olarak eşit etkilidir (9).…”

Preliminary investigation of the nasal delivery of liposomal leuprorelin acetate for contraception in rats

“…The nasal route is a non-invasive alternative route for the delivery of a number of macromolecules, including peptides, proteins and vaccines (Koushik & Kompella 2004). Intranasal albuterol was shown to offer an alternative to metered-dose inhalers for the treatment of acute bronchospasm and for prevention of exercise-induced asthma, especially for children and the elderly (Hussain et al 2004). Hence, liposomes and/or chitosan formulations containing leuprorelin acetate were prepared, characterized and subjected to pharmacokinetic and pharmacodynamic evaluation in rats.…”