2020
DOI: 10.1109/access.2020.3031353
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Narrow Operating Space Based on the Inversion of Latent Structures Model for Glycosylation Process

Abstract: N-linked glycan distribution plays a significant role in the generation of therapeutic proteins. It is challenging to determine the operating conditions when developing a new biopharmaceutical product with the desired glycan distributions. The glycosylation is a high complex nonlinear system, and it is difficult to develop a reliable first-principle model that heavily relies on experimentation. Our goal is to develop a nonlinear data-driven model and find an appropriate operating space included kinds of input … Show more

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