Narrow-band UVB–associated lesional blisters in pityriasis rubra pilaris

An update and guidance on narrowband ultraviolet B phototherapy: a British Photodermatology Group Workshop Report

“…In a study of patients with PLE, this was provoked in some during treatment with TL‐01, although this appears no more likely to occur than with PUVA 39 . Lesional blistering of psoriatic plaques has been observed mid‐way through a TL‐01 treatment course, requiring dose reduction; 69,70 the same phenomenon has also been reported during treatment of pityriasis rubra pilaris with TL‐01 71 . Perilesional erythema was not reported and the mechanism for blistering is unclear.…”

(Juvenile) Pityriasis rubra pilaris

“…109 Narrow-band UV-B with oral retinoids has also been useful in some cases. 110,111 Topical calcipotriol 112 and tacalcitol 113 have also given promising results. Synergism of vitamins A and E has also been made use of in PRP.…”

Photosensitive pityriasis rubra pilaris.

“…This may be a further therapeutic option in other patients whose PRP has flared with UVB phototherapy. It is important to remember, however, that there have also been a number of cases of uncomplicated PRP that have been successfully treated with narrow‐band UVB 6,7 …”

“…3,4 However, others describe improvement of disease with PUVA 3,4 and UVB. 6,7 There have been two other reports of PRP presenting in a photosensitive distribution. 3,4 The patient described by Kaskel et al 4 received photoprovocation on three consecutive days to the same sites with 1, 10 and 30 J ⁄ cm 2 ultraviolet A (UVA) and 20, 40 and dose; MED).…”