Narrow-band ultraviolet B phototherapy versus broad-band ultraviolet B or psoralen-ultraviolet A photochemotherapy for psoriasis

Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment

“…The very good response of adult AGP to NB-UVB in our study exceeds the results obtained with biologics in psoriasis [18] and suggested that NB-UVB should be the first line of treatment of AGP according to guidelines [7][8][9] , but it also raised a number of variables to consider when AGP is evaluated together with plaquetype psoriasis. This was the reason for analyzing other data in our group of patients.…”

“…According to guidelines for the treatment of psoriasis, the first line of treatment for psoriasis involving more than 5% of body surface area is ultraviolet phototherapy (preferably narrow-band ultraviolet B, NB-UVB), either alone or in combination with methotrexate or acitretin [7][8][9] . AGP has been demonstrated to respond to NB-UVB better than other forms of psoriasis [10,11] , but there is no consensus for the best treatment of AGP.…”

“…The PASI was shown in a recent systematic review to be the best outcome measure, and so PASI75 and PASI90 are the most used scores in the recent studies about the treatment of psoriasis [7,8,12] . In this article we studied the results of phototherapy with NB-UVB in adult AGP, collected possible triggers, family history and clinical course.…”

Phototherapy and Photochemotherapy for Psoriasis

“…20 The Cochrane review also compared the efficacy of NB-UV-B with oral PUVA for psoriasis. 12 The three RCTs they found show inconsistent results on the clearance rate, with one RCT showing equal efficacy and two a statistically significant higher clearance rate of oral PUVA. In terms of PASI 75 and withdrawals caused by adverse events no significant differences were found.…”

Current Approach to Phototherapy Applications in Dermatology Practice: Part 2. Phototherapy in Vitiligo, Mycosis Fungoides, Atopic Dermatitis, Sclerosing Diseases and Psoriasis

“…Bu nedenle de, psoriasiste birinci basamak fototerapi yöntemi dar bant UVB olup, PUVA'nın birinci basamağa geçebileceği durumlar, yaygın ve kalın plak psoriasis ve dar bant UVB'ye yetersiz yanıttır (44). Bunların dışında, PUVA ile daha az sayıda tedavi gerekli olduğu ve düzelme de daha uzun süre devam ettiği için (104), daha az sayıda seans ile yanıt elde edilmek istenen hastalarda veya dar bant UVB sonrası hızlı nüks olanlarda da PUVA birinci basamakta tercih edilebilir. PUVA'nın IL-10 pozitif regülatuvar T hücreleri indüklerken Th17 yolağını inhibe ettiği gösterilmiş ve bu etki mekanizmasının, PUVA'nın, inflamatuvar ve hiperproliferatif deri değişiklikleri üzerine olan hızlı ve uzun süreli etkisinden sorumlu olabileceği bildirilmiştir (105,106).…”