Narrow-Band Imaging Provides Reliable Screening for Esophageal Malignancy in Patients With Head and Neck Cancers

Takenaka, Ryuta; Kawahara, Yoshiro; Okada, Hiroyuki; Hori, Keisuke; Inoue, Masafumi; Kawano, Seiji; Tanioka, Daisuke; Tsuzuki, Takao; Uemura, Masayuki; Ohara, Nobuya; Tominaga, Susumu; Onoda, Tomoo; Yamamoto, Kazuhide

doi:10.1038/ajg.2009.426

Cited by 107 publications

(133 citation statements)

References 22 publications

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“…Endoscopic examinations with Lugol iodine staining are extremely useful for the early detection of esophageal cancer, as well as for the detection of secondary cancers associated with UADT cancers [56,57,72]. High-resolution narrow band imaging endoscopy, which improves visualization of the microvasculature and mucosal patterns in the alimentary tract, has recently been applied for the early detection of esophageal cancer as well as pharyngeal cancer [73,74]. In order to improve the prognosis of patients with ESCC, either endoscopy with Lugol staining or narrow band imaging endoscopy is strongly recommended for high-risk populations, such as smokers, heavy drinkers, people with experience of flushing after drinking alcohol, and patients with UADT cancer.…”

Section: Prevention and Early Detection Of Esccmentioning

confidence: 99%

Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention

et al. 2010

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Both cigarette smoking and alcohol drinking are well-established risk factors for esophageal squamous cell carcinoma (ESCC), and the relationship of dose to cancer risk has already been described. Furthermore, the synergistic effect of these two factors has been reported. Our case-control study revealed the odds ratio of ESCC to be 50.1 for those who were both heavy smokers and heavy drinkers in comparison to people who neither drank nor smoked. In patients with ESCC, head and neck cancers as well as dysplastic lesions are frequently observed. Heavy smoking and heavy drinking are closely related to such multicentric carcinogenesis events in the upper aerodigestive tract (UADT), including the esophagus and head andneck region. Polymorphisms in acetaldehyde dehydrogenase 2 (ALDH2) are reported to be a key event in deciding individual susceptibility to UADT cancer. Patients with inactive ALDH2, in whom facial flushing is usually observed after the drinking of alcohol, are at high risk for ESCC as well as multiple UADT cancers. For the early detection of the disease, effective follow up using endoscopy with Lugol staining or narrow band imaging endoscopy is strongly recommended for high-risk populations, such as smokers, heavy drinkers, people with experience of flushing after the drinking of alcohol, and patients with UADT cancer.

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Section: Prevention and Early Detection Of Esccmentioning

confidence: 99%

Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention

et al. 2010

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“…Furthermore, most of the Lugolvoiding lesions overlooked by NBI endoscopy were lowgrade intraepithelial neoplasia or lesions without atypical findings (24).…”

Section: Esophageal Sccmentioning

confidence: 99%

Narrow-band Imaging for the Head and Neck Region and the Upper Gastrointestinal Tract

Kikuchi¹,

Ezoe²,

Morita³

et al. 2013

Japanese Journal of Clinical Oncology

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Endoscopy is essential for the diagnosis and treatment of cancers derived from the gastrointestinal tract. However, a conventional white-light image has technical limitations in detecting small or superficial lesions. Narrow-band imaging, especially with magnification, allows visualization of microstructure patterns and microvascular patterns on the mucosal surface. These technical breakthroughs enable endoscopists to easily detect small pre-neoplastic and neoplastic lesions and to make a differential diagnosis of these lesions. Appropriate diagnosis with narrow-band imaging contributes to minimally invasive endoscopic resection.

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“…3,8,9,[12][13][14][15][16]22 In addition, metachronous esophageal cancers have been identified at different intervals, and the risk does not seem to decrease with time. 29 Therefore, according to recent guidelines, at least a single endoscopy may be indicated to search for esophageal cancer in patients with HNSCC.…”

Section: Discussionmentioning

confidence: 99%

“…Preliminary data have suggested that NBI is beneficial for screening esophageal tumors. 9,[13][14][15][16] In contrast, the role and effectiveness of FICE chromoendoscopy in the screening of ESCC remains to be determined.…”

mentioning

confidence: 98%

Effectiveness of Unsedated Transnasal Endoscopy With White-light, Flexible Spectral Imaging Color Enhancement, and Lugol Staining for Esophageal Cancer Screening in High-risk Patients

Arantes

Albuquerque

Salles

et al. 2013

Journal of Clinical Gastroenterology

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Narrow-Band Imaging Provides Reliable Screening for Esophageal Malignancy in Patients With Head and Neck Cancers

Abstract: NBI seems to be useful and reliable for screening for esophageal SCC in patients with head and neck cancers.

Cited by 107 publications

References 22 publications

Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention

Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention

Narrow-band Imaging for the Head and Neck Region and the Upper Gastrointestinal Tract

Effectiveness of Unsedated Transnasal Endoscopy With White-light, Flexible Spectral Imaging Color Enhancement, and Lugol Staining for Esophageal Cancer Screening in High-risk Patients

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