Narrative Review: Peripheral Arterial Disease in Patients with Hyperuricemia and Gout

Leung, Nicole; Fang, Chao; Pendse, Jay; Toprover, Michael; Pillinger, Michael H.

doi:10.1007/s11926-023-01100-1

Cited by 2 publications

(2 citation statements)

References 97 publications

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“…A recent review evidenced that patients with hyperuricemia are at high risk for developing PAD [44]. However, considering patient gender, controversial results were obtained.…”

Section: Vascular Diseasesmentioning

confidence: 99%

Gender Influence on XOR Activities and Related Pathologies: A Narrative Review

Bolognesi,

Bortolotti,

Battelli

et al. 2024

Antioxidants

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Taking into account the patient’s gender is the first step towards more precise and egalitarian medicine. The gender-related divergences observed in purine catabolism and their pathological consequences are good examples of gender medicine differences. Uric acid is produced by the activity of xanthine oxidoreductase (XOR). The serum levels of both XOR activity and uric acid differ physiologically between the genders, being higher in men than in women. Their higher levels have been associated with gout and hypertension, as well as with vascular, cardiac, renal, and metabolic diseases. The present review analyzes the gender-related differences in these pathological conditions in relation to increases in the serum levels of XOR and/or uric acid and the opportunity for gender-driven pharmacological treatment.

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“…A recent review evidenced that patients with hyperuricemia are at high risk for developing PAD [44]. However, considering patient gender, controversial results were obtained.…”

Section: Vascular Diseasesmentioning

confidence: 99%

Gender Influence on XOR Activities and Related Pathologies: A Narrative Review

Bolognesi,

Bortolotti,

Battelli

et al. 2024

Antioxidants

View full text Add to dashboard Cite

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“…This pathology is traditionally associated with gout; however, approximately two-thirds or more of such individuals remain asymptomatic, never developing gout, uric acid nephrolithiasis, or hyperuricemia nephropathy [5], although these clinical manifestations may develop in hyperuricemic individuals at any point. Persistent hyperuricemia is considered an independent risk factor for hypertension [6,7], diabetes [8], metabolic syndrome [9], and cardiovascular events [10], including stroke [11], coronary heart disease [12], and peripheral artery disease [13].…”

Section: Introductionmentioning

confidence: 99%

Association between Asymptomatic Hyperuricemia with Adiposity Indices: A Cross-Sectional Study in a Spanish Population

Sánchez-Bacaicoa,

Santano-Mogena,

Rico-Martín

et al. 2023

Nutrients

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Introduction: New anthropometric indices have been developed as an alternative to body mass index (BMI) and waist circumference (WC) to assess body mass and visceral fat. Asymptomatic hyperuricemia is considered an independent cardiovascular risk factor. Currently, little is known about the relationship between asymptomatic hyperuricemia and several new anthropometric indices. This study aimed to assess the association between the presence of asymptomatic hyperuricemia and anthropometric indices, both novel and traditional. Methods: This study analyzed 1094 Spanish subjects who consecutively visited the cardiovascular risk consultation of the University Hospital San Pedro de Alcántara of Cáceres, Spain, between June 2021 and September 2022. Anthropometric measures, including traditional and novel indices, were determined. The asymptomatic hyperuricemia group was defined according to serum uric acid levels. Results: All the anthropometric indices studied, including new and traditional, were significantly greater among patients with asymptomatic hyperuricemia, except for WWI. In multiple linear regression analysis, serum uric acid levels were significantly correlated with BMI, WHR, WHtR, AVI, BAI, BRI, CUN-BAE, and WWI but not ABSI or CI. In the univariate analysis, all indices were associated with asymptomatic hyperuricemia (p < 0.05); however, only WHtR (adjusted OR: 2.93; 95% CI: 1.03–8.37; p = 0.044), AVI (adjusted OR: 1.46; 95% CI: 1.04–2.04; p = 0.026), and BRI (adjusted OR: 1.66; 95% CI: 1.19–2.32; p = 0.003) were significantly associated in multivariate analysis. Finally, WHtR, AVI, and BRI provided the largest AUCs. Conclusions: Our findings showed that WHtR, AVI, and BRI were independently positively associated with asymptomatic hyperuricemia and could be good predictors.

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Narrative Review: Peripheral Arterial Disease in Patients with Hyperuricemia and Gout

Cited by 2 publications

References 97 publications

Gender Influence on XOR Activities and Related Pathologies: A Narrative Review

Gender Influence on XOR Activities and Related Pathologies: A Narrative Review

Association between Asymptomatic Hyperuricemia with Adiposity Indices: A Cross-Sectional Study in a Spanish Population

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