Narrative review of the in vivo mechanics of the cervical spine after anterior arthrodesis as revealed by dynamic biplane radiography

Anderst, William

doi:10.1002/jor.23042

Cited by 4 publications

(7 citation statements)

References 87 publications

(156 reference statements)

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“…It is well known that the frequent occurrence of cervical spine diseases may be the results of abnormal spinal loading. 11 Thus, knowledge of biomechanical environment of cervical spine is essential for studying the etiology of cervical spinal diseases and for improving current prosthesis testing standard. In this study, the dynamic in vivo joint loading patterns, including intervertebral compressive and shear force and facet joint force, were comprehensively studied using the developed cervical spine MSK MBD model.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 The investigation of kinematics and kinetics of cervical spine, during the various head motion, will contribute to understand the pathogenesis of the adjacent segment disease, to study in vivo wear and sagittal imbalance. 10,11 However, direct acquisition of in vivo cervical spinal loading is not yet an easy task. Traditionally, spinal compressive forces are obtained by the conversion of intradiskal pressure (IDP) results.…”

Section: Introductionmentioning

confidence: 99%

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Prediction of in vivo lower cervical spinal loading using musculoskeletal multi-body dynamics model during the head flexion/extension, lateral bending and axial rotation

Diao

Hua

Zhang

2018

Proc Inst Mech Eng H

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Cervical spine diseases lead to a heavy economic burden to the individuals and societies. Moreover, frequent post-operative complications mean a higher risk of neck pain and revision. At present, controversy still exists for the etiology of spinal diseases and their associated complications. Knowledge of in vivo cervical spinal loading pattern is proposed to be the key to answer these questions. However, direct acquisition of in vivo cervical spinal loading remains challenging. In this study, a previously developed cervical spine musculoskeletal multi-body dynamics model was utilized for spinal loading prediction. The in vivo dynamic segmental contributions to head motion and the out-of-plane coupled motion were both taken into account. First, model validation and sensitivity analysis of different segmental contributions to head motion were performed. For model validation, the predicted intervertebral disk compressive forces were converted into the intradiskal pressures and compared with the published experimental measurements. Significant correlations were found between the predicted values and the experimental results. Thus, the reliability and capability of the cervical spine model was ensured. Meanwhile, the sensitivity analysis indicated that cervical spinal loading is sensitive to different segmental contributions to head motion. Second, the compressive, shear and facet joint forces at C3-C6 disk levels were predicted, during the head flexion/extension, lateral bending and axial rotation. Under the head flexion/extension movement, asymmetric loading patterns of the intervertebral disk were obtained. In comparison, symmetrical typed loading patterns were found for the head lateral bending and axial rotation movements. However, the shear forces were dramatically increased during the head excessive extension and lateral bending. Besides, a nonlinear correlation was seen between the facet joint force and the angular displacement. In conclusion, dynamic cervical spinal loading was both intervertebral disk angle-dependent and level-dependent. Cervical spine musculoskeletal multi-body dynamics model provides an attempt to comprehend the in vivo biomechanical surrounding of the human head-neck system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prediction of in vivo lower cervical spinal loading using musculoskeletal multi-body dynamics model during the head flexion/extension, lateral bending and axial rotation

Diao

Hua

Zhang

2018

Proc Inst Mech Eng H

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“…In fact, recent reports indicate that in vitro models fail to accurately predict clinical outcomes 5 . This may be due in part to an inability to accurately replicate in vivo motion characteristics beyond simple ROM measures 6 …”

Section: Introductionmentioning

confidence: 99%

“…5 This may be due in part to an inability to accurately replicate in vivo motion characteristics beyond simple ROM measures. 6 Various loading techniques have been developed in an attempt to perform material property testing on spines or to replicate in vivo spine kinematics and loading. In pure moment (PM) loading, the moment applied to the end vertebra is applied equally to all segments of the specimen.…”

mentioning

confidence: 99%

Assessing the biofidelity of in vitro biomechanical testing of the human cervical spine

Wawrose

Howington

LeVasseur

et al. 2020

Journal Orthopaedic Research

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In vitro biomechanical studies of the osteoligamentous spine are widely used to characterize normal biomechanics, identify injury mechanisms, and assess the effects of degeneration and surgical instrumentation on spine mechanics. The objective of this study was to determine how well four standards in vitro loading paradigms replicate in vivo kinematics with regards to the instantaneous center of rotation and arthrokinematics in relation to disc deformation. In vivo data were previously collected from 20 asymptomatic participants (45.5 ± 5.8 years) who performed full range of motion neck flexion‐extension (FE) within a biplane x‐ray system. Intervertebral kinematics were determined with sub‐millimeter precision using a validated model‐based tracking process. Ten cadaveric spines (51.8 ± 7.3 years) were tested in FE within a robotic testing system. Each specimen was tested under four loading conditions: pure moment, axial loading, follower loading, and combined loading. The in vivo and in vitro bone motion data were directly compared. The average in vitro instant center of rotation was significantly more anterior in all four loading paradigms for all levels. In general, the anterior and posterior disc heights were larger in the in vitro models than in vivo. However, after adjusting for gender, the observed differences in disc height were not statistically significant. This data suggests that in vitro biomechanical testing alone may fail to replicate in vivo conditions, with significant implications for novel motion preservation devices such as cervical disc arthroplasty implants.

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“…Therefore, understanding of the spinal biomechanics is critically important for investigation of the mechanisms of cervical spine disc diseases and for development of treatment modalities to restore neck function. However, a literature review indicated that few studies have been reported on the biomechanics of the cervical spine discs [16]. For example, sagittal plane magnetic resonance (MR) or plane X-ray images have been used to investigate disc space heights at nonweightbearing supine or weightbearing standing positions [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Ranges of Cervical Intervertebral Disc Deformation During an In Vivo Dynamic Flexion–Extension of the Neck

Mao

et al. 2017

Journal of Biomechanical Engineering

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While abnormal loading is widely believed to cause cervical spine disc diseases, in vivo cervical disc deformation during dynamic neck motion has not been well delineated. This study investigated the range of cervical disc deformation during an in vivo functional flexion-extension of the neck. Ten asymptomatic human subjects were tested using a combined dual fluoroscopic imaging system (DFIS) and magnetic resonance imaging (MRI)-based three-dimensional (3D) modeling technique. Overall disc deformation was determined using the changes of the space geometry between upper and lower endplates of each intervertebral segment (C3/4, C4/5, C5/6, and C6/7). Five points (anterior, center, posterior, left, and right) of each disc were analyzed to examine the disc deformation distributions. The data indicated that between the functional maximum flexion and extension of the neck, the anterior points of the discs experienced large changes of distraction/compression deformation and shear deformation. The higher level discs experienced higher ranges of disc deformation. No significant difference was found in deformation ranges at posterior points of all the discs. The data indicated that the range of disc deformation is disc level dependent and the anterior region experienced larger changes of deformation than the center and posterior regions, except for the C6/7 disc. The data obtained from this study could serve as baseline knowledge for the understanding of the cervical spine disc biomechanics and for investigation of the biomechanical etiology of disc diseases. These data could also provide insights for development of motion preservation surgeries for cervical spine.

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Narrative review of the in vivo mechanics of the cervical spine after anterior arthrodesis as revealed by dynamic biplane radiography

Cited by 4 publications

References 87 publications

Prediction of in vivo lower cervical spinal loading using musculoskeletal multi-body dynamics model during the head flexion/extension, lateral bending and axial rotation

Prediction of in vivo lower cervical spinal loading using musculoskeletal multi-body dynamics model during the head flexion/extension, lateral bending and axial rotation

Assessing the biofidelity of in vitro biomechanical testing of the human cervical spine

Ranges of Cervical Intervertebral Disc Deformation During an In Vivo Dynamic Flexion–Extension of the Neck

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