This Special Issue has developed out of a research symposium on Global Genetic Fictions, funded by Wellcome, which was held at the University of Leeds in April 2019. Involving historians, literary and cultural critics, it was a welcome opportunity to sample the wealth of humanities-based scholarship on genetic science, its cultural representations, and its ethical implications. This is a field that is gathering momentum; the two years since that symposium, for instance, have seen the publication of three important literary critical books on genetics: