“…Valeria D. Cantos, MD; Colleen F. Kelley, MD, MPH; Carlos del Rio, MD In the US, HIV diagnoses have decreased by 8% from 2017 to 2021, in part due to an increased uptake of preexposure prophylaxis (PrEP), a highly effective and safe biomedical intervention to prevent HIV acquisition. 1 Despite these encouraging data, considerable racial, ethnic, and regional disparities in new HIV diagnoses and PrEP use persist in the US and, paradoxically, are worsening as PrEP options and ac-cess increase. 2 While young (ages 13-34 years), Black, Latino, gay, bisexual, and other adolescents and men who have sex with men (MSM) living in the southern US carry the highest burden of new HIV diagnoses in the nation, 1 PrEP coverage in each of these demographic categories is lower than the national average of 30%.…”